52853-20-0

Upstream product

• 100-52-7 benzaldehyde 
• 124-40-3 dimethyl amine 
• 68-12-2 N,N-dimethyl-formamide 
• 71-43-2 benzene 
• 13880-55-2 N,N,N',N'-tetramethyl-C-phenylmethanediamine 
• 75-36-5 acetyl chloride 
• 129164-52-9 chloro(dimethylamino)-o-tolylarsine 

Downstream Products

• 112881-42-2 5,6,8,9-Tetrahydro-7-phenylquino<8,7-b><1,10>phenanthroline 
• 148066-23-3 7,8,13,14-Tetrahydro-6-phenylquino<8,7-k><1,8>phenanthroline 
• 39487-54-2 1-((dimethylamino)(phenyl)methyl)naphthalen-2-ol 
• 94318-23-7 2-(Dimethylaminophenylmethyl)cyclohexanone 
• 347896-88-2 dimethyl-[phenyl-(1-phenyl-1H-pyrrol-2-yl)-methyl]-amine 
• 35173-74-1 3,3'-bis-indolyl(phenyl)methane 
• 86926-25-2 N,N,N',N'-tetramethyl-1,2-diphenylethane-1,2-diamine 

Relevant academic research and scientific papers

Towards the Development of Frustrated Lewis Pair (FLP) Catalyzed Hydrogenations of Tertiary and Secondary Carboxylic Amides

The development of the frustrated Lewis pair catalyzed hydrogenation of tertiary and secondary amides is reviewed. Detailed insight into our strategies in order to overcome challenges during the reaction development process is provided. Furthermore, the d

One-pot conversion of aromatic compounds to the corresponding bis(indolyl)methanes by the Vilsmeier-Haack reaction

Various electron-rich aromatics could be smoothly converted into the corresponding bis(indolyl)methanes in good to moderate yields by treatment of electron-rich aromatics with POCl3 and DMF, followed by treatment with indole at room temperature. The present article is the first report on a novel metal-free one-pot method for the preparation of bis(indolyl)methanes from electron-rich aromatics.

Substituted 1 and 2 naphthol mannich bases

The invention relates to substituted 1 and 2 naphthol Mannich bases, a method for the production thereof, medicaments containing said compounds and the use of said compounds in the production of medicaments.

Towards phase-transfer catalysts with a chiral anion: Inducing asymmetry in the reactions of cations

The ability of chiral anions, for example bis[1,1′-bi-2-naphtholato]borate, to induce asymmetry in the reactions of prochiral cations was investigated. Ion-pairing of a borate anion with an aziridinium ion was demonstrated by NMR spectroscopy. The additio

Use of substituted 4-amino-1-phenylbutan-2-ol compounds as medicaments

The invention relates to the use of substituted 4-amino-1-phenylbutan-2-ol compounds in the form of their racemates, enantiomers, diastereomers or corresponding bases or corresponding salts of physiologically acceptable acids as regulators for the nocicep

Substituted pyrrole mannich bases to combat pain and allergic reactions

The invention relates to substituted pyrrole Mannich bases of general formula (I), wherein R1=H, a C1-10-alkyl-, aryl, a heteroaryl- or an aryl, heteroaryl-, CN, Br—, Cl or OH radical bound by a C1-6 alkylene group, R2=CH(R4)N(R5)(R6), R3, R3′, R3″ identically or individually represent H, F, Cl, Br, CF3, CN, NO2, SO2NH2, NHR′, SR8, OR9, CO(OR10), CH2CO(OR11), COR15, a C1-10-alkyl-, aryl-, heteroaryl- aryl radical or a heteroalkyl radical bound by a C1-6 alkylene group, R4=an unsubstituted phenyl radical or a phenyl radical substituted at least with C1-4 alkyl, C1-3-alkoxy-, halogen-, a method for the production of the above-mentioned compounds, medicaments containing said compounds, and the use of said compounds in the production of medicaments. Said active ingredients are particularly suitable for pain therapy, and for treating inflammatory and allergic reactions, drug or alcohol abuse, diarrhoea, gastritis, ulcers, cardiovascular diseases, urinary incontinence, depressions, states of shock, migranes, narcolepsy, overweight, asthma, glaucoma, hyperkinetic syndrome, lack of drive, bulimia, anorexia, catalepsia, anxiolysis increasing vigilance and/or increasing libido.

Subtituted indole mannich bases

The invention relates to substituted indole Mannich bases of formula (I), a method for the production thereof, medicaments containing said compounds and the use of said compounds in the production of medicaments, especially medicaments that are used to treat pain. In formula (I), R1,R2, R4-R7 have the meanings cited in claim 1, R3=formula (a) and R13=(substituted) phenyl.

Iminopinacol coupling with lithium: Electron-transfer mediators

The addition of tert-butyl borate or ethyl formate to N-alkylbenzalimines directs the reaction pathway from the Birch reduction to the pinacol-type coupling with lithium in THF; an analogous reaction with a dimethylimmonium salt requires a trace titanium catalyst as the electron-transfer mediator.

3-amin3-arylpropan-1-ol compounds, their preparation and use

3-amino-3-arylpropan-1-ol compounds of formula I: R1and R2independently denoting C1-6alkyl, or together denoting a (CH2)2-6ring optionally substituted by phenyl, R3denoting C3-6alkyl, C3-6cycloalkyl, aryl optionally containing heteroatoms and optionally substituted by R6to R8, or a substituted C1-3alkylphenyl of formula XII: ?R4and R5independently denoting C1-6alkyl, C3-6cycloalkyl, phenyl, benzyl, or phenethyl, or together forming a (CH2)3-6or CH2CH2OCH2CH2ring, R6to R8independently denoting H, F, Cl, Br, CHF2, CF3, OH, OCF3, OR14, NR15R16, SR14, phenyl, SO2CH3, SO2CF3, C1-6alkyl, CN, COOR14, or CONR15R16, or together forming a OCH2O, OCH2CH2O, CH═CHO, CH═C(CH3)O or (CH2)4ring, R14denoting C1-6alkyl, phenyl, benzyl, or phenethyl, R15and R16independently denoting H, C1-6alkyl, phenyl, benzyl or phenethyl, and A denoting optionally substituted aryl optionally containing heteroatoms, or a diastereomer or enantiomer or pharmaceutically acceptable salt thereof, and their preparation and use in pharmaceutical compositions.

3-amino-3-arylpropan-1-ol-compounds, their preparation and use

3-amino-3-arylpropan-1-ol compounds corresponding to the formula I in which R1to R5, A and X have the meanings according to claim1, and their preparation and use as medicaments.