59847-20-0

Upstream product

• 502-49-8 cycloactanone 
• 98-88-4 benzoyl chloride 
• 59847-24-4 (2-morpholino-1-cyclohepten-1-yl)-phenyl-methanone 
• 108-94-1 cyclohexanone 
• 3282-32-4 2-diazo-acetophenone 
• 1121-66-0 2-Cyclohepten-1-one 
• 100-51-6 benzyl alcohol 
• 7182-08-3 4-(1-cyclohepten-1-yl)morpholine 
• 7391-45-9 2-oxocycloheptanecarbonitrile 
• 502-42-1 cycloheptanone 
• 1056246-49-1 2-bromocycloheptanone 
• 65-85-0 benzoic acid 
• 93-58-3 benzoic acid methyl ester 
• 92249-99-5 2-<α-Amino-benzyliden>-cycloheptan-1-on 

Downstream Products

• 131223-44-4 1-phenyloct-7-ene-1,3-dione 
• 131223-45-5 7-hydroxy-7-phenylbicyclo<4.1.1>octan-2-one 
• 59847-30-2 Carbonic acid 2-benzoyl-cyclohept-1-enyl ester methyl ester 
• 191421-18-8 3-phenyl-1,4,5,6,7,8-hexahydrocyclohepta[c]pyrazole 
• 1204771-99-2 C₁₈H₁₇N₃O₂S 
• 1569280-17-6 C₂₀H₂₁N₃O₂S 

Relevant academic research and scientific papers

Intramolecular Vinylation of Aryl Rings by Vinyl Cations

A Lewis acid mediated intramolecular electrophilic vinylation of aryl rings by vinyl cations is reported. This reaction takes advantage of β-hydroxy-α-diazo ketones as vinyl cation precursors and provides good yields of tricyclic 1-indenones that contain

Trimethylchlorosilane-Mediated Mild α-Chlorination of 1,3-Dicarbonyl Compounds Promoted by Phenyliodonium Diacetate

Trimethylchlorosilane was used as chlorine source for the α-chlorination of 1,3-dicarbonyl compounds with phenyliodonium diacetate as oxidant at room temperature. The reaction allows the selective synthesis of α-monochlorinated products from different kinds of 1,3-dicarbonyl compounds in good yield. The potential possibility of this conversion for bromination has also been investigated.

Discovery of 2-(1H-indazol-1-yl)-thiazole derivatives as selective EP 1 receptor antagonists for treatment of overactive bladder by core structure replacement

We have designed a series of potent EP1 receptor antagonists. These antagonists are a series of 2-(1H-indazol-1-yl)-thiazoles in which the core structure was replaced with pyrazole-phenyl groups. In preliminary conscious rat cystometry experiments, two representative candidates, 2 and 22, increased bladder capacity. In particular, the increase using 22 was approximately 2-fold that of the baseline. More detailed profiling of this compound and further optimization of this series promises to provide a novel class of drug for treating overactive bladder (OAB).

Iridium-catalyzed reaction of enones with alcohols affording 1,3-diketones

An iridium-catalyzed coupling reaction of alcohols with enones has been successfully developed providing access to 1,3-diketones with high selectivity in good yields. This reaction provides an atom-economical route to 1,3-diketones from readily available

BICYCLIC NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS

A nitrogen-containing bicyclic heterocyclic compound represented by the following formula (1) is provided. When the compound or a salt thereof is administered to a human being or an animal, the compound has a strong antagonistic action against EP1 recepto

1,3-Diarylcycloalkanopyrazoles and diphenyl hydrazides as selective inhibitors of cyclooxygenase-2

Novel 1,3-diarylcycloalkanopyrazoles 1, and diphenyl hydrazides 2 were identified as selective inhibitors of cyclooxygenase-2. The 1,3-diaryl substitution pattern of the pyrazole ring in 1 differentiates these compounds from most of the known selective COX-2 inhibitors that contain two aryl rings at the adjacent positions on a heterocyclic or a phenyl ring. Similarly, the two phenyl rings in 2 are also separated by three atoms. SAR of both phenyl rings in 1 and 2, and the aliphatic ring in 1 will be discussed. (C) 2000 Elsevier Science Ltd. All rights reserved.

InCl3: A new Lewis acid catalyst for reactions with α-diazocarbonyl compounds

The use of InCl3 as a Lewis acid catalyst in diazocarbonyl S-H insertion reactions, nitrile cyclizations and addition reactions to aldehydes and ketones is described.