59853-92-8Relevant articles and documents
Potent and selective ketoamide-based inhibitors of cysteine protease, cathepsin K
Tavares, Francis X.,Deaton, David N.,Miller, Aaron B.,Miller, Larry R.,Wright, Lois L.,Zhou, Hui-Qiang
, p. 5049 - 5056 (2004)
Cathepsin K, a lysosomal cysteine protease of the papain superfamily, is abundantly and selectively expressed in osteoclasts, suggesting that this enzyme is crucial for bone resorption. Prevention of osteoclast-mediated bone resorption via inhibition of c
