59893-99-1

Basic information

• Product Name: N-(p-chlorobenzoyl)-glycine methyl ester
• Synonyms: N-(p-chlorobenzoyl)-glycine methyl ester
• CAS NO: 59893-99-1
• Molecular Weight: 227.647
• Mol File: 59893-99-1.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: N-(p-chlorobenzoyl)-glycine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-(p-chlorobenzoyl)-glycine methyl ester(59893-99-1)
• EPA Substance Registry System: N-(p-chlorobenzoyl)-glycine methyl ester(59893-99-1)

Safety Data

• Hazardous Substances Data: 59893-99-1(Hazardous Substances Data)

Upstream product

• 5680-79-5 glycine ethyl ester hydrochloride 
• 74-11-3 para-chlorobenzoic acid 
• 883886-67-7 amino-acetic acid methyl ester hydrochloride salt 
• 873-76-7 para-Chlorobenzyl alcohol 
• 104-88-1 4-chlorobenzaldehyde 
• 171806-95-4 N-(4-(phenylmethoxy)benzoyl)glycine methyl ester 
• 122-01-0 4-chloro-benzoyl chloride 
• 186581-53-3 diazomethane 
• 13450-77-6 4-chlorohippuric acid 
• 616-34-2 methoxycarbonylmethylamine 

Downstream Products

• 125700-13-2 α-methoxy-N-(4-chlorobenzoyl)glycine methyl ester 
• 125700-14-3 α,α-dimethoxy-N-(4-chlorobenzoyl)-glycine methyl ester 
• 62086-70-8 methyl (4-hydroxybenzoyl)glycinate 
• 7400-54-6 4-chloro-N-(2-hydroxyethyl)-benzamide 
• 71320-77-9 moclobemide 
• 51847-02-0 4-chloro-N-(2-chloroethyl)benzamide 
• 13450-77-6 4-chlorohippuric acid 
• 90098-04-7 rebamipide 
• 915017-74-2 N-[4-(3-phenylpropoxy)benzoyl]glycine 
• 1268161-48-3 5-chloro-2-(4-chlorophenyl)oxazole-4-carbaldehyde 

Relevant articles and documents

Addressing hERG activity while maintaining favorable potency, selectivity and pharmacokinetic properties of PPARδ modulators

One of the most commonly used strategies to reduce hERG (human ether-a-go-go) activity in the drug candidates is introduction of a carboxylic acid group. During the optimization of PPARδ modulators, some of the compounds containing a carboxylic acid were found to inhibit the hERG channel in a patch clamp assay. By modifying the basicity of the imidazole core, potent and selective PPARδ modulators that do not inhibit hERG channel were identified. Some of the modulators have excellent pharmacokinetic profiles in mice.

PPAR AGONISTS, COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF

Provided herein are compounds and compositions useful in increasing PPARδ activity. The compounds and compositions provided herein are useful for the treatment of PPARδ related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).

Iron-catalyzed benzamide formation. Application to the synthesis of moclobemide

A convenient and user-friendly method to yield benzamides from primary and secondary amines and various benzylic alcohols in the presence of a cheap iron salt (FeCl2$4H2O) and tert-butylhydroperoxide (70% in water) as a stoichiometric oxidant is described. Control experiments indicated that this reaction might involve radical species. This method proved to be general, generating a family of 30 benzamides and was applied to the preparative synthesis of anti-anxiety drug moclobemide.