59896-06-9

Upstream product

• 30080-45-6 ((3aR,5S,6R,6aR)-2,2,6-trimethyl-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanol 
• 98-88-4 benzoyl chloride 
• 59896-02-5 ((3aR,5S,6aR)-2,2-dimethyl-6-methylenetetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methyl benzoate 
• 26293-58-3 (3aR,5S,6R,6aR)-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,2,6-trimethyl-tetrahydrofuro[2,3-d][1,3]dioxole 
• 21665-16-7 O¹,O²;O⁵,O⁶-diisopropylidene-3-methylene-α-D-ribo-3-deoxy-hexofuranose 
• 2847-00-9 1,2:5,6-di-O-isopropylidene-α-D-hexofuran-3-ulose 
• 16831-81-5 ((3aR,5R,6R,6aR)-6-hydroxy-2,2,6-trimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methyl benzoate 

Downstream Products

• 609846-23-3 (2S,3S,4R)-2-benzoyloxymethyl-3-methyltetrahydrofuran-4-ol 
• 609846-27-7 Benzoic acid (2S,3R,4R)-4-methanesulfonyloxy-3-methyl-tetrahydro-furan-2-ylmethyl ester 
• 609846-24-4 Benzoic acid (2S,3S,4S)-4-(6-amino-purin-9-yl)-3-methyl-tetrahydro-furan-2-ylmethyl ester 
• 136061-53-5 Acetic acid (E)-(3R,4S)-2-benzenesulfonyl-4-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethyl-1-[(4S,5S,6R)-2,2,5-trimethyl-6-((Z)-2-methylsulfanyl-vinyl)-[1,3]dioxan-4-yl]-hept-5-enyl ester 
• 136061-37-5 Benzoic acid (4S,5R,6R)-6-(bis-ethylsulfanyl-methyl)-2,2,5-trimethyl-[1,3]dioxan-4-ylmethyl ester 
• 136061-39-7 Benzoic acid (4S,5S,6R)-2,2,5-trimethyl-6-((Z)-2-methylsulfanyl-vinyl)-[1,3]dioxan-4-ylmethyl ester 
• 136061-38-6 Benzoic acid (4S,5R,6R)-6-formyl-2,2,5-trimethyl-[1,3]dioxan-4-ylmethyl ester 

Relevant academic research and scientific papers

Revisited 3′-deoxy-3′-C-methyl-β-D-ribonucleoside series

The synthesis of some 3′-deoxy-3′-C-methylnucleoside analogues bearing naturally occuring nucleic acid bases was achieved from the preparation of a suitable peracylated 3-deoxy-3-C-methyl sugar using a stereoselective pathway. In addition, examples of chemical modifications at the 2′ position are presented. Copyright Taylor & Francis Group, LLC.

Synthesis of 3′-deoxy-3′-C-methyl-β-d-ribonucleoside analogs

3′-Deoxy-3′-C-methyl-β-d-ribonucleoside analogs bearing the five canonical bases of nucleic acids have been synthesized. All these derivatives were prepared by glycosylation of the corresponding heterocyclic bases with a suitable peracylated 3-C-methyl su

Cyclopropyl and related analogs of the anti-HIV compound, isodideoxyadenosine

Novel 3′-substituted isonucleoside analogs were designed on the basis of the similarities of their electrostatic potential with the active anti-HIV compound, (S, S)-isodideoxy-adenosine. The key synthetic step involved coupling between the dideoxygenated sugar derivatives, 10 and 14, and adenine under Mitsunobu conditions. Anti-HIV data are mentioned.