60200-91-1

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-4'-iodobiphenyl is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medical treatments.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Chloro-4'-iodobiphenyl serves as a starting material for the production of various agrochemicals. Its properties make it suitable for use in the creation of pesticides and other agricultural chemicals that are essential for maintaining crop health and productivity.
Used in Liquid Crystal Production:
4-Chloro-4'-iodobiphenyl is utilized as a starting material in the production of liquid crystals. These liquid crystals are vital components in a range of display technologies, including televisions, computer monitors, and smartphone screens.
Used in Dye and Pigment Manufacturing:
4-Chloro-4'-iodobiphenyl is also employed as a chemical intermediate in the manufacture of dyes and pigments. Its presence in these products contributes to the vibrant colors and stability seen in various industries, such as textiles, plastics, and inks.
Used in Polymer Production:
4-Chloro-4'-iodobiphenyl is used in the synthesis of polymers, which are essential materials in numerous applications across various industries. Its role in polymer chemistry helps to create new materials with improved properties and performance.
Environmental Considerations:
While 4-Chloro-4'-iodobiphenyl has significant industrial applications, it has also been identified as a potential pollutant due to its persistence and bioaccumulation in the environment. It is crucial to handle and dispose of this chemical compound with care to prevent harm to ecosystems and human health.

Upstream product

• 135-68-2 4-(4-chlorophenyl)aniline 
• 2051-62-9 4'-biphenyl chloride 
• 637-87-6 1-Chloro-4-iodobenzene 
• 17865-11-1 (4-(trimethylsilyl)phenyl)boronic acid 
• 17908-92-8 (4'-chloro-biphenyl-4-yl)-trimethyl-silane 
• 1591-31-7 4-iodo-biphenyl 
• 540-37-4 p-aminoiodobenzene 
• 17902-37-3 1-bromo-4-[(chloromethyl)dimethylsilyl]benzene 
• 106-37-6 1.4-dibromobenzene 
• 288608-09-3 1-(2,5-dimethyl-1H-pyrrol-1-yl)-4-iodobenzene 
• 1679-18-1 4-Chlorophenylboronic acid 
• 177490-72-1 (4-Bromo-phenyl)-chloromethoxymethyl-dimethyl-silane 
• 591-50-4 iodobenzene 
• 10312-71-7 1,6-bis-(4-chlorophenyl)-3,4-diacetyl-1,5-hexazadiene 

Downstream Products

• 2051-62-9 4'-biphenyl chloride 
• 942589-53-9 2-(4'-chloro-[1,1'-biphenyl]-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 

Relevant academic research and scientific papers

Palladium-Catalyzed Enantioselective C(sp3)-H Arylation of 2-Propyl Azaaryls Enabled by an Amino Acid Ligand

A palladium(II)-catalyzed enantioselective arylation of unbiased secondary C(sp3)-H bonds was developed. The enantioselectivity was controlled by the combination of a pyridyl or isoquinolinyl directing group and an amino acid, N-Boc-2-pentyl proline. A variety of 2-propyl azaaryls and biaryl iodides were employed to provide arylated products in moderate to good yields (up to 82%) with high enantioselectivities (up to 93:7 er). This reaction is a rare example of an amino-acid-enabled enantioselective acyclic methylene C(sp3)-H arylation. Furthermore, the reaction proceeded with high enantioselectivity even on a gram scale, and the product was transformed to a 5,6,7,8-tetrahydroisoquinoline bioactive molecule. Kinetic isotope effect (KIE) experiments indicated that C-H activation is the rate-determining step for the enantioselective C(sp3)-H arylation.

Palladium-Catalyzed Secondary C(sp3)?H Arylation of 2-Alkylpyridines

A pyridyl group-assisted palladium-catalyzed secondary C(sp3)?H arylation protocol was developed. A substituent at the 3-position of the pyridyl group is proved to be important for promoting C?H arylation and controlling the regioselectivity. Aryl iodides can be used as coupling partners. The reaction proceeded in good to excellent yields with good functional group tolerance, even on the gram-scale. The preliminary asymmetric reaction was investigated using an L-proline derivative as a chiral ligand. (Figure presented.).

The chlorinated aromatic iodine compound method

PROBLEM TO BE SOLVED: To provide an industrially advantageous production method that makes it possible to produce aromatic chloroiodine compounds.SOLUTION: A production method of an aromatic chloroiodine compound is characterized by making an aromatic iodine compound and a sulfuryl chloride react with each other in the presence of a specific Lewis acid catalyst and a sulfur compound.

Synthesis of functionalized thiophene/phenyl co-oligomers by direct arylation of thiophenes

π-Conjugated rod-like molecules have proven to be powerful candidates for the generation of well-defined nanostructures with interesting optical and optoelectrical properties. Their synthesis, however, turns out to be rather complex in some cases. Here, we have optimized the synthesis of oligomers consisting of thiophene and phenylene groups with three or four aromatic units using a direct arylation approach, which allows us to use cheap starting materials and to minimize the number of reaction steps considerably.

Synthesis and antiplasmodial activity of new indolone N-Oxide derivatives

A series of 66 new indolone-N-oxide derivatives was synthesized with three different methods. Compounds were evaluated for in vitro activity against CQ-sensitive (3D7), CQ-resistant (FcB1), and CQ and pyrimethamine cross-resistant (K1) strains of Plasmodium falciparum (P.f.), aswell as for cytotoxic concentration (CC50) on MCF7 and KB human tumor cell lines. Compound 26 (5-methoxy-indolone-N-oxide analogue) had the most potent antiplasmodial activity in vitro (50 MCF7/IC50 FcB1: 14623; CC50 KB/IC50 3D7: 198823). In in vivo experiments, compound 1 (dioxymethylene derivatives of the indolone-N-oxide) showed the best antiplasmodial activity against Plasmodium berghei, 62% inhibition of the parasitaemia at 30 mg/kg/day. 2009 American Chemical Society.

Synthesis of monofunctionalized p-quaterphenyls

p-Oligophenyls have proven to be versatile building blocks for the generation of self-assembled nanoaggregates via vapor deposition on solid supports whose optical properties and morphologies can be influenced by the introduction of functional groups. Non

Synthesis of symmetrically and unsymmetrically para-functionalized p-quaterphenylenes

Oligo-p-phenylenes have proven to be versatile building blocks for the generation of self-assembled nanoaggregates with interesting optical properties via vapor deposition on solid supports. Preliminary studies have shown that both the properties and the morphologies of these aggregates can be influenced by the introduction of functional groups. To this end, we have developed general approaches to the synthesis of symmetrically and unsymmetrically 1,4?-substituted p-quaterphenylenes through the application of a reliable Suzuki cross-coupling strategy. Georg Thieme Verlag Stuttgart.

Silicon directed ipso-substitution of polymer bound arylsilanes: Preparation of biaryls via the Suzuki cross-coupling reaction

A method for attaching haloarylsilanes to polymer support was developed. The polymer bound arylhalide were reacted with a variety of ArB(OH)2 under the Suzuki cross-coupling reaction conditions and the coupled resins were cleaved by different electrophiles to give ipso-substitution products in good yields.

Analogues of clofibrate and clobuzarit containing fluorine in the side chains

A series of analogues of clofibrate and 2-[4-(4-chlorophenyl)phenylmethoxy]-2-methylpropionic acid (clobuzarit) has been prepared by replacing the methyl groups by trifluoromethyl groups and changing the aromatic moiety. The activity of these compounds has been assayed on the plasma levels of cholesterol, Total Esterified Fatty Acids (T.E.F.A.) and fibrinogen in rats. It appears that derivatives of the first series which contain only one trifluoromethyl group are hypocholesterolaemic and that many mono- of bis- trifluoromethyl derivatives of the second series lower the levels of both cholesterol and T.E.F.A. in contrast to clobuzarit.

Aryl radicals from hexazadienes and tetrazenes

Aryl radicals are produced from both ends of the hexazadienes 1 and 2 and from the tetrazene 3, either thermally or photolytically.They attack aromatic compounds in the nucleus, the yield of biaryl being in the range 40-70percent, though it can be made nearly quantitative by using m-dinitrobenzene as additive.The aryl radicals also oxidize 2-propanol to acetone, the reaction products being the halogenobenzene and 1,2-diacetylhydrazine.Photolysis of 1 goes mainly by way of the tetrazene 3, and this may also be a significant pathway in the thermal reaction.Azodiacetylis an intermediate in the thermal reaction of 1 with 2-propanol and may be generally so in all its reactions.Radical induced decomposition is believed to be important in the reactions of 1, 2, and 3, and it is probably responsible for the formation of 1-acetyl-1-arylhydrazines, routinely produced in yields up to 25percent.