60200-91-1

Basic information

• Product Name: 4-Chloro-4'-iodobiphenyl
• Synonyms: 4-Chloro-4'-iodobiphenyl;1,1'-Biphenyl,4-chloro-4'-iodo-;4-Chloro-4'-iodo-1,1'-biphenyl;1-Chloro-4-(4-iodophenyl)benzene;HCHAMYGZDLHKMD-UHFFFAOYSA-N
• CAS NO: 60200-91-1
• Molecular Formula: C₁₂H₈ClI
• Molecular Weight: 314.54939
• Mol File: 60200-91-1.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Chloro-4'-iodobiphenyl(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-4'-iodobiphenyl(60200-91-1)
• EPA Substance Registry System: 4-Chloro-4'-iodobiphenyl(60200-91-1)

Safety Data

• Hazardous Substances Data: 60200-91-1(Hazardous Substances Data)

Usage

General Description

4-Chloro-4'-iodobiphenyl is a chemical compound containing a biphenyl structure with chlorine and iodine substituents. It is a halogenated organic compound commonly used as a building block in the synthesis of various organic compounds, including pharmaceuticals and agrochemicals. It is known for its role as a starting material in the production of liquid crystals and as a chemical intermediate in the manufacture of dyes, pigments, and polymers. Additionally, 4-Chloro-4'-iodobiphenyl has been studied for its potential environmental impact and has been identified as a potential pollutant due to its persistence and bioaccumulation in the environment. While it has industrial applications, it is important to handle and dispose of this chemical compound properly to prevent harm to the environment and human health.

Upstream product

• 135-68-2 4-(4-chlorophenyl)aniline 
• 591-50-4 iodobenzene 
• 10312-71-7 1,6-bis-(4-chlorophenyl)-3,4-diacetyl-1,5-hexazadiene 
• 2051-62-9 4'-biphenyl chloride 
• 1591-31-7 4-iodo-biphenyl 
• 637-87-6 1-Chloro-4-iodobenzene 
• 17865-11-1 (4-(trimethylsilyl)phenyl)boronic acid 
• 17908-92-8 (4'-chloro-biphenyl-4-yl)-trimethyl-silane 
• 540-37-4 p-aminoiodobenzene 
• 177490-80-1 Acetic acid [(4-bromo-phenyl)-dimethyl-silanyl]-methyl ester 
• 177490-81-2 [(4-Bromo-phenyl)-dimethyl-silanyl]-methanol 
• 17902-37-3 1-bromo-4-[(chloromethyl)dimethylsilyl]benzene 
• 106-37-6 1.4-dibromobenzene 
• 288608-09-3 1-(2,5-dimethyl-1H-pyrrol-1-yl)-4-iodobenzene 

Downstream Products

• 2051-62-9 4'-biphenyl chloride 
• 942589-53-9 2-(4'-chloro-[1,1'-biphenyl]-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 

Relevant articles and documents

Palladium-Catalyzed Enantioselective C(sp3)-H Arylation of 2-Propyl Azaaryls Enabled by an Amino Acid Ligand

A palladium(II)-catalyzed enantioselective arylation of unbiased secondary C(sp3)-H bonds was developed. The enantioselectivity was controlled by the combination of a pyridyl or isoquinolinyl directing group and an amino acid, N-Boc-2-pentyl proline. A variety of 2-propyl azaaryls and biaryl iodides were employed to provide arylated products in moderate to good yields (up to 82%) with high enantioselectivities (up to 93:7 er). This reaction is a rare example of an amino-acid-enabled enantioselective acyclic methylene C(sp3)-H arylation. Furthermore, the reaction proceeded with high enantioselectivity even on a gram scale, and the product was transformed to a 5,6,7,8-tetrahydroisoquinoline bioactive molecule. Kinetic isotope effect (KIE) experiments indicated that C-H activation is the rate-determining step for the enantioselective C(sp3)-H arylation.

The chlorinated aromatic iodine compound method

PROBLEM TO BE SOLVED: To provide an industrially advantageous production method that makes it possible to produce aromatic chloroiodine compounds.SOLUTION: A production method of an aromatic chloroiodine compound is characterized by making an aromatic iodine compound and a sulfuryl chloride react with each other in the presence of a specific Lewis acid catalyst and a sulfur compound.

Synthesis and antiplasmodial activity of new indolone N-Oxide derivatives

A series of 66 new indolone-N-oxide derivatives was synthesized with three different methods. Compounds were evaluated for in vitro activity against CQ-sensitive (3D7), CQ-resistant (FcB1), and CQ and pyrimethamine cross-resistant (K1) strains of Plasmodium falciparum (P.f.), aswell as for cytotoxic concentration (CC50) on MCF7 and KB human tumor cell lines. Compound 26 (5-methoxy-indolone-N-oxide analogue) had the most potent antiplasmodial activity in vitro (50 MCF7/IC50 FcB1: 14623; CC50 KB/IC50 3D7: 198823). In in vivo experiments, compound 1 (dioxymethylene derivatives of the indolone-N-oxide) showed the best antiplasmodial activity against Plasmodium berghei, 62% inhibition of the parasitaemia at 30 mg/kg/day. 2009 American Chemical Society.