60246-82-4

Basic information

• Product Name: 1,5-Benzothiazepine, 2-(4-chlorophenyl)-2,3-dihydro-4-phenyl-
• CAS NO: 60246-82-4
• Molecular Formula: C21H16ClNS
• Molecular Weight: 349.884
• Mol File: 60246-82-4.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: 1,5-Benzothiazepine, 2-(4-chlorophenyl)-2,3-dihydro-4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-Benzothiazepine, 2-(4-chlorophenyl)-2,3-dihydro-4-phenyl-(60246-82-4)
• EPA Substance Registry System: 1,5-Benzothiazepine, 2-(4-chlorophenyl)-2,3-dihydro-4-phenyl-(60246-82-4)

Safety Data

• Hazardous Substances Data: 60246-82-4(Hazardous Substances Data)

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 98-86-2 acetophenone 
• 956-04-7 3-(4-chlorophenyl)-1-phenylprop-2-en-1-one 
• 137-07-5 2-amino-benzenethiol 
• 60246-64-2 β-(2-Aminophenylmercapto)-β-phenyl-propiophenone 
• 40358-31-4 2,3-dihydro-2,4-diphenyl-1,5-benzothiazepine 
• 1155-00-6 bis(2-nitrophenyl)disulfide 
• 24721-26-4 4-chlorochalcone 

Downstream Products

• 1307301-56-9 ethyl 3a,4-dihydro-3,3a-diphenyl-5-(4-chlorophenyl)-5H-[1,2,4]triazolo[5,4-d][1,5]benzothiazepine-1-carboxylate 
• 1307301-58-1 ethyl 3a,4-dihydro-3-(4-methylphenyl)-3a-phenyl-5-(4-chlorophenyl)-5H-[1,2,4]triazolo[5,4-d][1,5]benzothiazepine-1-carboxylate 
• 1307301-57-0 ethyl 3a,4-dihydro-3-(4-chlorophenyl)-3a-phenyl-5-(4-chlorophenyl)-5H-[1,2,4]triazolo[5,4-d][1,5]benzothiazepine-1-carboxylate 
• 1371288-76-4 4-(4-chlorophenyl)-2-phenoxy-2a-phenyl-2,2a,3,4-tetrahydro-1H-azeto[2,1-d][1,5]benzothiazepin-1-one 
• 156875-26-2 6-(4-chloro-phenyl)-2,3,4a-triphenyl-5,6-dihydro-4aH-4-oxa-7-thia-11b-aza-dibenzo[a,c]cyclohepten-1-one 

Relevant articles and documents

Ionic Liquid-Assisted Preparation of Co3O4 Nanosheets as a New and Efficient Catalyst for Green Synthesis of Various 1,5-Benothiazepine Derivatives in Water

Abstract: A novel and green method for the preparation of cobalt oxide nanosheets using pyridinium-based ionic liquid by simple reflux method is described in the present work. Pyridinium-based ionic liquid, N-butyl pyridinium bromide [BuPy]Br plays an important role as reaction media and morphology template to control Co3O4 nanostructures. This catalyst is characterized by XRD, FE-SEM, FT-IR, VSM and UV-Visible spectroscopy. Further, this nanocatalyst is used to catalyzes the condensation reaction of o-amino thiophenol with α,β-unsaturated ketones for preparation of 1,5-benzothiazepine derivatives in excellent yields. This efficient catalyst could be recovered and reused several times without any significant loss of activity.

Catalyst-free synthesis of 2,3-dihydro-1,5-benzothiazepines in a renewable and biodegradable reaction medium

A clean and efficient strategy for the synthesis of benzothiazepines from chalcone and ortho-aminothiophenol has been reported. Here, glycerol, a biodegradable and reusable promoting medium, has been utilized under acid, base or metal-free conditions. The

Efficient and eco-friendly syntheses of 1,5-benzothiazepines and 1,5-benzodiazepines catalyzed by [Hmim][NO3] under mild conditions

This article presents a synthetic method and reaction mechanism of the 1,5-benzothiazepines and 1,5-benzodiazepines derivatives. In this research, 36 thiazepines and diazepines (mostly new) with a new method have been prepared and their structures have been characterized by spectroscopic methods. Crystal structures of a new thiazepine and diazepine (seven-membered rings) have also been determined and compared with thiazine (six-membered ring). In this method, N-methylimidazolium nitrate [Hmim][NO3] has been used as a catalyst that acts as an environmental friendly system.