60246-82-4

Upstream product

• 1155-00-6 bis(2-nitrophenyl)disulfide 
• 956-04-7 3-(4-chlorophenyl)-1-phenylprop-2-en-1-one 
• 40358-31-4 2,3-dihydro-2,4-diphenyl-1,5-benzothiazepine 
• 60246-64-2 β-(2-Aminophenylmercapto)-β-phenyl-propiophenone 
• 104-88-1 4-chlorobenzaldehyde 
• 98-86-2 acetophenone 
• 137-07-5 2-amino-benzenethiol 
• 24721-26-4 4-chlorochalcone 

Downstream Products

• 156875-26-2 6-(4-chloro-phenyl)-2,3,4a-triphenyl-5,6-dihydro-4aH-4-oxa-7-thia-11b-aza-dibenzo[a,c]cyclohepten-1-one 
• 1371288-76-4 4-(4-chlorophenyl)-2-phenoxy-2a-phenyl-2,2a,3,4-tetrahydro-1H-azeto[2,1-d][1,5]benzothiazepin-1-one 
• 1307301-56-9 ethyl 3a,4-dihydro-3,3a-diphenyl-5-(4-chlorophenyl)-5H-[1,2,4]triazolo[5,4-d][1,5]benzothiazepine-1-carboxylate 
• 1307301-58-1 ethyl 3a,4-dihydro-3-(4-methylphenyl)-3a-phenyl-5-(4-chlorophenyl)-5H-[1,2,4]triazolo[5,4-d][1,5]benzothiazepine-1-carboxylate 
• 1307301-57-0 ethyl 3a,4-dihydro-3-(4-chlorophenyl)-3a-phenyl-5-(4-chlorophenyl)-5H-[1,2,4]triazolo[5,4-d][1,5]benzothiazepine-1-carboxylate 

Relevant academic research and scientific papers

Synthesis, characterization, in vitro cholinesterase and hRBCs hemolysis assay and computational evaluation of novel 2,3,4,5-tetrahydrobenzothiazepine appended α-aminophosphonates

A series of novel 2,3,4,5-tetrahydrobenzothiazepine appended α-aminophosphonate derivatives were synthesized by subjecting 2,3-dihydrobenzothiazepine to Pudovik reaction using diethyl phosphite. Tested derivatives exhibited better AChE inhibition (0.86–12

Ionic Liquid-Assisted Preparation of Co3O4 Nanosheets as a New and Efficient Catalyst for Green Synthesis of Various 1,5-Benothiazepine Derivatives in Water

Abstract: A novel and green method for the preparation of cobalt oxide nanosheets using pyridinium-based ionic liquid by simple reflux method is described in the present work. Pyridinium-based ionic liquid, N-butyl pyridinium bromide [BuPy]Br plays an important role as reaction media and morphology template to control Co3O4 nanostructures. This catalyst is characterized by XRD, FE-SEM, FT-IR, VSM and UV-Visible spectroscopy. Further, this nanocatalyst is used to catalyzes the condensation reaction of o-amino thiophenol with α,β-unsaturated ketones for preparation of 1,5-benzothiazepine derivatives in excellent yields. This efficient catalyst could be recovered and reused several times without any significant loss of activity.

Catalyst-free synthesis of 2,3-dihydro-1,5-benzothiazepines in a renewable and biodegradable reaction medium

A clean and efficient strategy for the synthesis of benzothiazepines from chalcone and ortho-aminothiophenol has been reported. Here, glycerol, a biodegradable and reusable promoting medium, has been utilized under acid, base or metal-free conditions. The

A practical synthesis of 2,3-dihydro-1,5-benzothiazepines

2,3-Dihydro-1,5-benzothiazepines have been obtained through a domino process involving a Michael addition of 2-aminothiophenols to chalcones, followed by in situ cyclization. Up to 98% chemical yields have been obtained at room temperature under essential

Efficient and eco-friendly syntheses of 1,5-benzothiazepines and 1,5-benzodiazepines catalyzed by [Hmim][NO3] under mild conditions

This article presents a synthetic method and reaction mechanism of the 1,5-benzothiazepines and 1,5-benzodiazepines derivatives. In this research, 36 thiazepines and diazepines (mostly new) with a new method have been prepared and their structures have been characterized by spectroscopic methods. Crystal structures of a new thiazepine and diazepine (seven-membered rings) have also been determined and compared with thiazine (six-membered ring). In this method, N-methylimidazolium nitrate [Hmim][NO3] has been used as a catalyst that acts as an environmental friendly system.

Facile synthesis of 1,5-benzothiazepines in water using tetrabutylammonium tribromide

A simple, environmentally benign, and efficient method was developed for the preparation of 1,5-benzothiazepines via a one-pot condensation reaction of 2-aminothiophenol with 1,3-diaryl-2-propenones using tetrabutylammonium tribromide as an efficient and versatile catalyst in water.

Synthesis and structure characterization of new [1,2,4]triazolo[5,4-d][1,5] benzothiazepine derivatives through 1,3-dipolar cycloaddition reaction

Reaction of 1,5-benzothiazepines 3, obtained from chalcones 2 and o-aminobenzenthiol, with the (phenylhydrazino) chloromethylenecarboxylates 4 in the presence of Et3N leads to a series of new [1,2,4]triazolo[5,4-d] [1,5]benzothiazepine derivatives 5. Their structures were established using spectroscopic methods and that of compound 5d was confirmed using X-ray diffraction analysis.

An efficient synthesis of 1,5-benzothiazepines in the presence of sub-stoichiometric amount of cyanuric chloride

An efficient synthesis of 1,3-diaryl-2,3-dihydro-1,5-benzothiazepines has been developed by the reaction of various 1,3-diaryl-2-propenones with 2-aminothiophenol under thermal solvent-free conditions in the presence of a sub-stoichiometric amount of cyanuric chloride.

Syntheses of potentially bioactive [1,2,4]oxadiazolo[5,4-d]benzothiazepines by 1,3-dipolar cycloaddition

The chalcones, 2a-2l reacted with o-aminobenzenthiol to give a series of 1,5-benzothiazepines, 3a-3l. The [3+2] 1, 3-dipolar cycloaddition reactions of 3a-3l with ethyl chlorooximidoacetate in the presence of Et3N afforded the target compounds, 4a-4l possessing an additional 1,2,4-oxadiazole ring fused to the heptaatomic nucleus. The structures have been elucidated by spectral methods and X-ray crystallographic analysis.

Green protocol for synthesis of 1,5-benzodiazepines and 1,5-benzothiazepines in the presence of nanocrystalline aluminum oxide

An efficient protocol associated with readily available starting materials, mild conditions, excellent yields, and a broad range of the products in synthetic chemistry was established for synthesis of 1,5-benzodiazepine and 1,5-benzothiazepine derivatives