60246-82-4Relevant academic research and scientific papers
Synthesis, characterization, in vitro cholinesterase and hRBCs hemolysis assay and computational evaluation of novel 2,3,4,5-tetrahydrobenzothiazepine appended α-aminophosphonates
Shaikh, Sarfaraz,Dhavan, Pratik,Uparkar, Jasmin,Singh, Pinky,Vaidya,Jadhav,Ramana
, (2021/10/12)
A series of novel 2,3,4,5-tetrahydrobenzothiazepine appended α-aminophosphonate derivatives were synthesized by subjecting 2,3-dihydrobenzothiazepine to Pudovik reaction using diethyl phosphite. Tested derivatives exhibited better AChE inhibition (0.86–12
Ionic Liquid-Assisted Preparation of Co3O4 Nanosheets as a New and Efficient Catalyst for Green Synthesis of Various 1,5-Benothiazepine Derivatives in Water
Darband,Tahanpesar,Sanaeishoar,Badri
, p. 1624 - 1634 (2022/03/23)
Abstract: A novel and green method for the preparation of cobalt oxide nanosheets using pyridinium-based ionic liquid by simple reflux method is described in the present work. Pyridinium-based ionic liquid, N-butyl pyridinium bromide [BuPy]Br plays an important role as reaction media and morphology template to control Co3O4 nanostructures. This catalyst is characterized by XRD, FE-SEM, FT-IR, VSM and UV-Visible spectroscopy. Further, this nanocatalyst is used to catalyzes the condensation reaction of o-amino thiophenol with α,β-unsaturated ketones for preparation of 1,5-benzothiazepine derivatives in excellent yields. This efficient catalyst could be recovered and reused several times without any significant loss of activity.
Catalyst-free synthesis of 2,3-dihydro-1,5-benzothiazepines in a renewable and biodegradable reaction medium
Yadav, Neetu,Yadav, Vijay B.,Ansari, Mohd Danish,Sagir, Hozeyfa,Verma, Ankit,Siddiqui
supporting information, p. 7011 - 7014 (2019/05/17)
A clean and efficient strategy for the synthesis of benzothiazepines from chalcone and ortho-aminothiophenol has been reported. Here, glycerol, a biodegradable and reusable promoting medium, has been utilized under acid, base or metal-free conditions. The
A practical synthesis of 2,3-dihydro-1,5-benzothiazepines
Albanese, Domenico C. M.,Gaggero, Nicoletta,Fei, Meng
supporting information, p. 5703 - 5707 (2017/12/06)
2,3-Dihydro-1,5-benzothiazepines have been obtained through a domino process involving a Michael addition of 2-aminothiophenols to chalcones, followed by in situ cyclization. Up to 98% chemical yields have been obtained at room temperature under essential
Efficient and eco-friendly syntheses of 1,5-benzothiazepines and 1,5-benzodiazepines catalyzed by [Hmim][NO3] under mild conditions
Loghmani-Khouzani, Hossein,Tamjidi, Panteha,Mohammadpoor-Baltork, Iraj,Yaeghoobi, Marzieh,Rahman, Noorsaadah Abd.,Khosropour, Ahmad Reza,Moghadam, Majid,Tangestaninejad, Shahram,Mirkhani, Valiolah,Habibi, Mohammad Hossein,Kashima, Ayana,Suzuki, Takayoshi
, p. 138 - 150 (2014/02/14)
This article presents a synthetic method and reaction mechanism of the 1,5-benzothiazepines and 1,5-benzodiazepines derivatives. In this research, 36 thiazepines and diazepines (mostly new) with a new method have been prepared and their structures have been characterized by spectroscopic methods. Crystal structures of a new thiazepine and diazepine (seven-membered rings) have also been determined and compared with thiazine (six-membered ring). In this method, N-methylimidazolium nitrate [Hmim][NO3] has been used as a catalyst that acts as an environmental friendly system.
Facile synthesis of 1,5-benzothiazepines in water using tetrabutylammonium tribromide
Yan, Yunhui,Yang, Xiaojuan,Wu, Liqiang
experimental part, p. 573 - 579 (2012/06/01)
A simple, environmentally benign, and efficient method was developed for the preparation of 1,5-benzothiazepines via a one-pot condensation reaction of 2-aminothiophenol with 1,3-diaryl-2-propenones using tetrabutylammonium tribromide as an efficient and versatile catalyst in water.
Synthesis and structure characterization of new [1,2,4]triazolo[5,4-d][1,5] benzothiazepine derivatives through 1,3-dipolar cycloaddition reaction
Wu, Xiao-Long,Liu, Fang-Ming,Zhou, Ying-Lei
, p. 368 - 372 (2011/05/14)
Reaction of 1,5-benzothiazepines 3, obtained from chalcones 2 and o-aminobenzenthiol, with the (phenylhydrazino) chloromethylenecarboxylates 4 in the presence of Et3N leads to a series of new [1,2,4]triazolo[5,4-d] [1,5]benzothiazepine derivatives 5. Their structures were established using spectroscopic methods and that of compound 5d was confirmed using X-ray diffraction analysis.
An efficient synthesis of 1,5-benzothiazepines in the presence of sub-stoichiometric amount of cyanuric chloride
Sun, Pengli,Fang, Lizheng,Wu, Liqiang
experimental part, p. 257 - 261 (2012/01/03)
An efficient synthesis of 1,3-diaryl-2,3-dihydro-1,5-benzothiazepines has been developed by the reaction of various 1,3-diaryl-2-propenones with 2-aminothiophenol under thermal solvent-free conditions in the presence of a sub-stoichiometric amount of cyanuric chloride.
Syntheses of potentially bioactive [1,2,4]oxadiazolo[5,4-d]benzothiazepines by 1,3-dipolar cycloaddition
Wu, Xiao-Long,Liu, Fang-Ming,Shen, Song-Wei
experimental part, p. 1350 - 1355 (2011/01/05)
The chalcones, 2a-2l reacted with o-aminobenzenthiol to give a series of 1,5-benzothiazepines, 3a-3l. The [3+2] 1, 3-dipolar cycloaddition reactions of 3a-3l with ethyl chlorooximidoacetate in the presence of Et3N afforded the target compounds, 4a-4l possessing an additional 1,2,4-oxadiazole ring fused to the heptaatomic nucleus. The structures have been elucidated by spectral methods and X-ray crystallographic analysis.
Green protocol for synthesis of 1,5-benzodiazepines and 1,5-benzothiazepines in the presence of nanocrystalline aluminum oxide
Hekmatshoar, Rahim,Sadjadi, Sodeh,Shiri, Soudeh,Heravi, Majid M.,Beheshtiha, Yahya S.
experimental part, p. 2549 - 2559 (2009/12/04)
An efficient protocol associated with readily available starting materials, mild conditions, excellent yields, and a broad range of the products in synthetic chemistry was established for synthesis of 1,5-benzodiazepine and 1,5-benzothiazepine derivatives
