60252-77-9

Basic information

• Product Name: 2-Propenamide, N-(4-fluorophenyl)-
• CAS NO: 60252-77-9
• Molecular Formula: C9H8FNO
• Molecular Weight: 165.167
• Mol File: 60252-77-9.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: 2-Propenamide, N-(4-fluorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenamide, N-(4-fluorophenyl)-(60252-77-9)
• EPA Substance Registry System: 2-Propenamide, N-(4-fluorophenyl)-(60252-77-9)

Safety Data

• Hazardous Substances Data: 60252-77-9(Hazardous Substances Data)

Usage

Derivative of

2-propenamide (acrylamide)

Addition

4-fluorophenyl group

Aromatic Fluorine Atom

Introduces aromaticity and fluorine properties

Potential Applications

Pharmaceuticals, materials science, organic synthesis

Physicochemical Properties

Requires further research and testing

Upstream product

• 590-92-1 3-Bromopropionic acid 
• 371-40-4 4-fluoroaniline 
• 352-34-1 4-fluoro-1-iodobenzene 
• 79-06-1 2-propenamide 
• 350-46-9 4-Fluoronitrobenzene 
• 814-68-6 acryloyl chloride 
• 340011-44-1 N-(4-fluorophenyl)-3-(phenylsulfonyl)propanamide 

Downstream Products

• 340011-49-6 N-allyl N-(4-fluorophenyl)acrylamide 
• 1412410-78-6 (E)-N-(4-fluorophenyl)-3-(7-methoxy-4-oxo-4H-chromen-3-yl)acrylamide 
• 159671-84-8 1-Benzyl-4-[2-(4-fluorophenylaminocarbonyl)ethyl] piperazine 

Relevant articles and documents

Synthesis of 4-Trifluoromethylated 1,3-Butadienes via Palladium Catalyzed Heck Reaction

1,3-Butadiene plays a key role in modern synthetic chemistry and biochemistry because it is a key intermediate in the synthesis of many drugs. A new and effective method for the synthesis of 4-trifluoromethylated 1,3-butadiene through the fluorinated Heck reaction catalyzed by Pd(0) is described. Without additives, 1-chloro-3,3,3-trifluoropropene (an inexpensive CF3 structural unit that is harmless to ozone) reacts with enamide to synthesize 4-trifluoromethylated 1,3-butadienes with good yield, high regioselectivity and chemical selectivity, and strong tolerance of substrate functional groups such as alkynes, aldehyde, and ester groups.

Rh(i)-Catalyzed regioselective arylcarboxylation of acrylamides with arylboronic acids and CO2

The first Rh(i)-catalyzed regioselective arylcarboxylation of electron-deficient acrylamides with arylboronic acids under atmospheric pressure of CO2 has been developed. A range of acrylamides and arylboronic acids were compatible with this reaction under redox-neutral conditions, leading to a series of malonate derivatives that are versatile building blocks in organic syntheses.

COMPOSITONS AND METHODS FOR MODULATING UBA5

Disclosed herein, inter alia, are compositions and methods useful for inhibiting ubiquitin-like modifier activating enzyme 5.