60509-75-3Relevant academic research and scientific papers
Oxalic acid as a simple and efficient organocatalyst for three-component synthesis of α-amino nitriles
Vahdat, Seyed Mohammad,Khaksar, Samad,Khavarpour, Maryam
experimental part, p. 543 - 546 (2012/01/14)
A simple, efficient, and general method has been developed for the synthesis of α-amino nitriles. Oxalic acid as a Br?nsted acid promotes the addition of TMSCN to various imines (generated in situ).
Trifluoroethanol as a metal-free, homogeneous and recyclable medium for the efficient one-pot synthesis of α-amino nitriles and α-amino phosphonates
Heydari, Akbar,Khaksar, Samad,Tajbakhsh, Mahmood
body text, p. 77 - 80 (2009/04/14)
Trifluoroethanol is found to be an efficient and recyclable medium in promoting one-pot, three-component coupling reactions of aldehydes or ketones, amines and trimethylsilyl cyanide or trimethyl phosphite to afford the corresponding α-amino nitriles or α-amino phosphonates in high yields. This protocol does not require the use of an acid or base catalyst.
New Synthesis of β-Lactams Based on Nitrone Cycloaddition to Nitroalkenes
Padwa, Albert,Koehler, Konrad F.,Rodriguez, Augusto
, p. 282 - 288 (2007/10/02)
Heating a sample of the major 5-nitro-substituted isoxazolidine isomer obtained from the reaction of a C-phenyl-N-alkylnitrone with trans-1-cyano-2-nitroethylene in methanol resulted in ring contraction and formation of 4-phenyl-3-cyano-N-alkyl-2-azetidin
