60566-44-1

Basic information

• Product Name: methyl N-tert-butoxycarbonyl-L-tyrosyldiglycyl-L-phenylalanyl-L-methioninate
• Synonyms: methyl N-tert-butoxycarbonyl-L-tyrosyldiglycyl-L-phenylalanyl-L-methioninate
• CAS NO: 60566-44-1
• Molecular Weight: 687.814
• Mol File: 60566-44-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: methyl N-tert-butoxycarbonyl-L-tyrosyldiglycyl-L-phenylalanyl-L-methioninate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl N-tert-butoxycarbonyl-L-tyrosyldiglycyl-L-phenylalanyl-L-methioninate(60566-44-1)
• EPA Substance Registry System: methyl N-tert-butoxycarbonyl-L-tyrosyldiglycyl-L-phenylalanyl-L-methioninate(60566-44-1)

Safety Data

• Hazardous Substances Data: 60566-44-1(Hazardous Substances Data)

Upstream product

• 3978-80-1 Boc-Tyr-OH 
• 180776-66-3 (S)-2-{(S)-2-[2-(2-Azido-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid methyl ester 
• 180776-69-6 N-azidoacetylglycyl-L-phenylalanine 
• 180776-68-5 (S)-2-[2-(2-Azido-acetylamino)-acetylamino]-3-phenyl-propionic acid methyl ester 
• 78450-66-5 Z(OMe)-Phe-Met-OMe 
• 78450-65-4 Z(OMe)-Gly-Phe-Met-OMe 
• 40290-65-1 hydrochloride of methyl ester of L-phenylalanyl-L-methionine 
• 180776-67-4 (S)-2-[2-(2-Chloro-acetylamino)-acetylamino]-3-phenyl-propionic acid methyl ester 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 10332-17-9 Met-OMe 
• 67729-36-6 Boc-Phe-O-COO-isoBu 
• 70035-45-9 N-tert-Butyloxycarbonyl-glycyl-glycyl-L-phenylalanyl-L-methionin-methylester 
• 40290-63-9 Methyl ester of N-t-butyloxycarbonyl-L-phenylalanyl-L-methionine 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 

Downstream Products

• 59481-77-5 boc-Tyr-Gly-Gly-Phe-Met-OH 
• 58569-55-4 met-enkephalin 
• 82689-18-7 Boc-L-Tyr-Gly-Gly-L-Phe-L-Met-al 
• 75524-83-3 Boc-Tyr-Gly-Gly-Phe-Met-NHNH₂ 
• 64569-47-7 Boc-L-Tyr-Gly-Gly-L-Phe-L-Met-alcohol 

Relevant articles and documents

Dynamic Kinetic Cross-Electrophile Arylation of Benzyl Alcohols by Nickel Catalysis

Catalytic transformation of alcohols via metal-catalyzed cross-coupling reactions is very important, but it typically relies on a multistep procedure. We here report a dynamic kinetic cross-coupling approach for the direct functionalization of alcohols. The feasibility of this strategy is demonstrated by a nickel-catalyzed cross-electrophile arylation reaction of benzyl alcohols with (hetero)aryl electrophiles. The reaction proceeds with a broad substrate scope of both coupling partners. The electron-rich, electron-poor, and ortho-/meta-/para-substituted (hetero)aryl electrophiles (e.g., Ar-OTf, Ar-I, Ar-Br, and inert Ar-Cl) all coupled well. Most of the functionalities, including aldehyde, ketone, amide, ester, nitrile, sulfone, furan, thiophene, benzothiophene, pyridine, quinolone, Ar-SiMe3, Ar-Bpin, and Ar-SnBu3, were tolerated. The dynamic nature of this method enables the direct arylation of benzylic alcohol in the presence of various nucleophilic groups, including nonactivated primary/secondary/tertiary alcohols, phenols, and free indoles. It thus offers a robust alternative to existing methods for the precise construction of diarylmethanes. The synthetic utility of the method was demonstrated by a concise synthesis of biologically active molecules and by its application to peptide modification and conjugation. Preliminary mechanistic studies revealed that the reaction of in situ formed benzyl oxalates with nickel, possibly via a radical process, is an initial step in the reaction with aryl electrophiles.

A fast procedure for the preparation of amides/peptides from carboxylic acids and azides via two redox reactions: Application to the synthesis of methionine enkephalin

A one-pot self regulated approach for the synthesis of amides/peptides based on two reduction-oxidation (redox) reactions has been described. The primary and secondary amides/peptides are made by using azidotrimethylsilane and alkyl azides/α-azido acid de

New methods and reagents in organic synthesis. 29. A practical method for the preparation of optically active N-protected α-amino aldehydes and peptide aldehydes

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