60579-19-3

Basic information

• Product Name: 5-(4-chlorophenyl)-3-phenyl-4,5-dihydroisoxazole
• Synonyms: 5-(4-chlorophenyl)-3-phenyl-4,5-dihydroisoxazole
• CAS NO: 60579-19-3
• Molecular Weight: 257.719
• Mol File: 60579-19-3.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 5-(4-chlorophenyl)-3-phenyl-4,5-dihydroisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-chlorophenyl)-3-phenyl-4,5-dihydroisoxazole(60579-19-3)
• EPA Substance Registry System: 5-(4-chlorophenyl)-3-phenyl-4,5-dihydroisoxazole(60579-19-3)

Safety Data

• Hazardous Substances Data: 60579-19-3(Hazardous Substances Data)

Upstream product

• 5739-39-9 3-(4-chlorophenyl)-1-phenylpropan-1-one 
• 1073-67-2 4-vinylbenzyl chloride 
• 156605-56-0 1-phenylethan-1-one O-pivaloyl oxime 
• 104-88-1 4-chlorobenzaldehyde 
• 25327-36-0 (Z)-2-(hydroxyimino)-2-phenylacetic acid 
• 100-52-7 benzaldehyde 
• 932-90-1 Benzaldoxime 
• 98-86-2 acetophenone 
• 956-04-7 3-(4-chlorophenyl)-1-phenylprop-2-en-1-one 
• 24721-26-4 4-chlorochalcone 

Downstream Products

• 1148-87-4 5-(4-chlorophenyl)-3-phenylisoxazole 

Relevant articles and documents

TEMPO-Mediated Selective Synthesis of Isoxazolines, 5-Hydroxy-2-isoxazolines, and Isoxazoles via Aliphatic δ-C(sp3)-H Bond Oxidation of Oximes

Selective synthesis of three different bioactive heterocycles; isoxazolines, 5-hydroxy-2-isoxazolines and isoxazoles from the same starting material using TEMPO (2,2,6,6-Tetramethylpiperidin-1-oxyl) as a radical initiator is reported. Selectivity was achi

Synthesis of Isoxazolines and Isoxazoles via Metal-Free Desulfitative Cyclization

A novel, one-pot reaction for the synthesis of isoxazolines and isoxazoles is developed via a cascade process under metal-free conditions. The approach involves the formation of intramolecular C-N and C-O bonds and intermolecular C-C bonds from aromatic alkenes or alkynes and N -hydroxysulfonamides using hypervalent iodine(VII) and iodine as the oxidant. Activation of C-H and C-C bonds/construction of C-O bonds/elimination of SO 2 /C-N bond formation is achieved in sequence in the reaction system.

3,4,5-trisubstituted-4,5-dihydroisoxazole, derivative and synthetic method and application thereof

The invention relates to 3,4,5-trisubstituted-4,5-dihydroisoxazole, a derivative and a synthetic method and an application thereof. The invention mainly relates to a synthetic method of an isoxazoline compound. With adoption of a technical scheme that an aldehyde compound and oxime ester are converted into isoxazoline and the derivative thereof by taking an organic solvent as a solvent under the action of alkali without using a catalyst, the synthetic method solves the problem that an existing synthetic method of the isoxazoline compound is complicated in synthetic step, is accomplished by adopting multiple steps, and also needs a metal catalyst, a chemically equivalent metal oxidant or a peroxide. The atom economy is kept to the extreme extent; the isoxazoline compound has a stable molecular structure and an excellent chemical property, and molecular slices and compound segments contain rich contents with biological activity and pharmacological activity. The isoxazoline compound also has the characteristics of being simple in reaction system, mild in reaction condition, relatively less in reaction equipment, simple in experimental operation, wide in source of materials, high in yield, easy for expansion of user and application, relatively high in utilization value of product and expectable in market commercial prospect.