65576-66-1

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 105-34-0 methyl 2-cyanoacetate 
• 2186-92-7 p-Anisaldehyde dimethyl acetal 
• 67-56-1 methanol 
• 107-91-5 cyanoacetic acid amide 
• 88818-49-9 1-(4-methoxyphenyl)-2-nitro-1-buten-3-one 
• 105202-53-7 3-(4-methoxyphenyl)-2-nitro-1-phenyl-2-propen-1-one 

Downstream Products

• 75140-48-6 methyl 2-cyano-3-(4-methoxyphenyl)propionate 
• 1199874-05-9 methyl 2-cyano-3-(4-methoxyphenyl)-3-(1H-pyrrol-2-yl)propanoate 
• 607697-15-4 methyl 2-amino-4-(4-methoxyphenyl)-5-oxo-4,5-dihydropyrano[3,2-c]chromene-3-carboxylate 
• 65576-57-0 5-amino-2-(4-methoxy-benzylidene)-7-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-7H-thiazolo[3,2-a]pyridine-6,8-dicarboxylic acid dimethyl ester 

Relevant academic research and scientific papers

Direct Cyclopropanation of α-Cyano β-Aryl Alkanes by Light-Mediated Single Electron Transfer Between Donor–Acceptor Pairs

Cyclopropanes are traditionally prepared by the formal [2+1] addition of carbene or radical based C1 units to alkenes. In contrast, the one-pot intermolecular cyclopropanation of alkanes by redox active C1 units has remained unrealised. Herein, we achieve

Protic Ionic Liquid as Reagent, Catalyst, and Solvent: 1-Methylimidazolium Thiocyanate

We propose a new concept of the triple role of protic ionic liquids with nucleophilic anions: a) a regenerable solvent, b) a Br?nsted acid inducing diverse transformations via general acid catalysis, and c) a source of a nucleophile. The efficiency of this strategy was demonstrated using thiocyanate-based protic ionic liquids for the ring-opening of donor-acceptor cyclopropanes. A wide variety of activated cyclopropanes were found to react with 1-methylimidazolium thiocyanate under mild metal-free conditions via unusual nitrogen attack of the ambident thiocyanate ion on the electrophilic center of the three-membered ring affording pyrrolidine-2-thiones bearing donor and acceptor substituents at the C(5) and C(3) atoms, respectively, in a single time-efficient step. The ability of 1-methylimidazolium thiocyanate to serve as a triplex reagent was exemplarily illustrated by (4+2)-annulation with 1-acyl-2-(2-hydroxyphenyl)cyclopropane, epoxide ring-opening and other organic transformations.

A Tailored Heptazine-Based Porous Polymeric Network as a Versatile Heterogeneous (Photo)catalyst

A heptazine-based microporous polymeric network, HMP-TAPA was synthesised by direct coupling of trichloroheptazine and tris(4-aminophenyl)amine (TAPA). A high surface area of 424 m2/g was achieved, which is the highest surface area among heptaz

One-Pot Synthesis of γ-Azidobutyronitriles and Their Intramolecular Cycloadditions

Efficient gram-scale, one-pot approaches to azidocyanobutyrates and their amidated or decarboxylated derivatives have been developed, starting from commercially available aldehydes and cyanoacetates. These techniques combine (1) Knoevenagel condensation,

Diastereoselective Synthesis of Spiro[2.3]hexanes from Methylenecyclopropane and Cyanoalkenes Catalyzed by a Tin-Ate Complex

A diastereoselective synthesis of spiro[2.3]hexane catalyzed by Sn and Mg halides was developed from a combination of methylenecyclopropane and cyanoalkene bearing an ester group. The selectivity was affected by the size of the halogen in the catalyst and

A reinforced Pickering emulsion for cascade reactions

Based on an interfacial sol-gel process, a novel reinforced Pickering emulsion has been developed successfully for one-pot cascade reactions involving incompatible catalysts.

Green and efficient synthesis method for aryl acrylonitrile compound

The invention discloses a green and efficient synthesis method for an aryl acrylonitrile compound represented by formula III. The method comprises the following steps: in an air atmosphere, by takingaryl acetonitrile of formula I as shown in the specification and excess methyl cyanoacetate of formula II as shown in the specification as raw materials, and Ru/C as a catalyst, enabling the components to react at 150-160 DEG C in the absence of a solvent, and separating and purifying a reaction mixture obtained after the reaction is completed, thereby obtaining an aryl acrylonitrile compound of formula III as shown in the specification. The method disclosed by the invention is not only low in production cost, but also good in environment protection, and is very applicable to industrial large-scale production.

Microporous polyurethane material for size selective heterogeneous catalysis of the Knoevenagel reaction

The first polyurethane material which is microporous (BET surface area of 312 m2 g-1) is prepared by solvothermal synthesis and acts as highly efficient and recyclable heterogeneous catalyst in the Knoevenagel condensation showing si

Direct Three-Component Synthesis of α-Cyano Acrylates Involving Cascade Knoevenagel Reaction and Esterification

A direct three-component approach has been developed for the synthesis of α-cyano acrylates starting from aldehydes, alcohols and α-cyano acetamide by employing cyanuric chloride as an organocatalyst. A class of structurally diverse α-cyano acrylates have been provided with good to excellent yields via the cascade transformation of Knoevenagel condensation and amide esterification.

Reductive alkylation of active methylene compounds with carbonyl derivatives, calcium hydride and a heterogeneous catalyst

A one-pot two-step reaction (Knoevenagel condensation - reduction of the double bond) has been developed using calcium hydride as a reductant in the presence of a supported noble metal catalyst. The reaction between carbonyl compounds and active methylene