4836-00-4

Basic information

• Product Name: syn-2-Nitrobenzaldoxime [Deprotecting Agent]
• Synonyms: (E)-N-hydroxy-1-(2-nitrophenyl)methanimine
• CAS NO: 4836-00-4
• Molecular Formula: C₇H₆N₂O₃
• Molecular Weight: 166.13414
• Mol File: 4836-00-4.mol
• Article Data: 46

Chemical Properties

• Melting Point: 93.0 to 97.0 °C
• Boiling Point: 305.2±25.0 °C(Predicted)
• Appearance: /
• Density: 1.33±0.1 g/cm3(Predicted)
• PKA: 10.08±0.10(Predicted)
• CAS DataBase Reference: syn-2-Nitrobenzaldoxime [Deprotecting Agent](CAS DataBase Reference)
• NIST Chemistry Reference: syn-2-Nitrobenzaldoxime [Deprotecting Agent](4836-00-4)
• EPA Substance Registry System: syn-2-Nitrobenzaldoxime [Deprotecting Agent](4836-00-4)

Safety Data

• Hazardous Substances Data: 4836-00-4(Hazardous Substances Data)

Usage

General Description

Syn-2-Nitrobenzaldoxime is a deprotecting agent used in the synthesis of various compounds. It is a chemical compound that is commonly used to remove protective groups from organic molecules. syn-2-Nitrobenzaldoxime [Deprotecting Agent] is known for its ability to selectively deprotect certain functional groups without affecting other parts of the molecule. Its deprotecting properties make it a valuable tool in organic synthesis, particularly in the production of pharmaceuticals, agrochemicals, and other fine chemicals. Overall, syn-2-Nitrobenzaldoxime plays a crucial role in the efficient and selective deprotection of functional groups in various organic compounds.

Upstream product

• 87-91-2 diethyl (2R,3R)-tartrate 
• 6635-41-2 (Z)-2-nitrobenzaldehyde oxime 
• 135436-97-4 2-nitrobenzaldehyde-(O-methyl oxime) 
• 868775-48-8 C-(2-nitrophenyl)-N-(2,3-dimethoxybenzyl)-nitrone 
• 552-89-6 2-nitro-benzaldehyde 
• 1904-78-5 2-nitrobenzylamine 
• 88-72-2 1-methyl-2-nitrobenzene 
• 110-46-3 isopentyl nitrite 
• 109-73-9 N-butylamine 
• 116435-81-5 (4-amino-2-nitrophenyl)acetic acid 
• 3848-29-1 O-Benzoyl-2-nitro-benzaldehyd-oxim 
• 271-58-9 anthranil 
• 612-25-9 2-Nitrobenzyl alcohol 
• 95982-61-9 o-nitro-N-benzyl(benzylamine) 

Downstream Products

• 610-15-1 2-nitrobenzamide 
• 35447-75-7 N-hydroxy-2-nitrobenzimidoyl chloride 
• 612-24-8 o-nitrobenzonitrile 
• 6635-41-2 (Z)-2-nitrobenzaldehyde oxime 
• 41542-54-5 N-Hydroxy-2-nitro-thiobenzimidic acid 2-diethylamino-ethyl ester 
• 116081-77-7 o-nitrobenzonitrolic acid 
• 108801-21-4 bis-(2-nitro-benzylidene)-hydrazine-N_.N'-dioxide 
• 135436-97-4 O-methyl-2-nitro-benz-anti-aldoxime 
• 552-89-6 2-nitro-benzaldehyde 
• 135436-97-4 (E)-2-nitrobenzaldehyde O-methyl oxime 
• 603-54-3 N,N-diphenylurea 
• 62-53-3 aniline 
• 14442-25-2 3-(2-nitrophenyl)-5-phenyl-1,2-oxazole 
• 5855-52-7 2-phenylquinolin-4-amine 

Relevant articles and documents

Preparation method O - alkyl substituted hydroxylamine salt

The invention relates to a preparation method of N - alkyl substituted hydroxylamine salt, and belongs to fine chemical engineering. Pesticide or bulk pharmaceutical chemicals technical field. The present invention reacts with the N - alkyl of the oxime with an inorganic salt of hydroxylamine to give N - alkyl-substituted hydroxylamine salt and oxime. The invention provides an efficient and environment-friendly method for preparing N - alkyl substituted hydroxylamine salt, and simultaneously, an N - alkyl substituted hydroxylamine salt is prepared, and the oxime can be re-prepared to form N - alkylate of oxime so as to realize the material circulation. No equivalent acid is used in the reaction process. Alkali neutralization, avoided the current method to use a large amount of acid, alkali and produce inorganic salt solid waste shortcoming, environmental protection more. The preparation method is mild in reaction condition, and the defects of high pollution and high energy consumption of the traditional process are overcome. In-flight R1 , R2 What is R is as claimed in the claims and the description.

Electrophilically activated nitroalkanes in synthesis of 3,4-dihydroquinozalines

Nitroalkanes activated with polyphosphoric acid serve as efficient electrophiles in reactions with various nucleophilic amines. Strategically placed second functionality allows for the design of annulation reactions enabling preparation of various heterocycles. This strategy was employed to develop an innovative synthetic approach towards 3,4-dihydroquinazolines from readily available 2-(aminomethyl)anilines.

HCl-mediated cascade cyclocondensation of oxygenated arylacetic acids with arylaldehydes: one-pot synthesis of 1-arylisoquinolines

In this paper, a concise, open-vessel synthesis of 1-arylisoquinolines is describedviaHCl-mediated intermolecular cyclocondensation of oxygenated arylacetic acids with arylaldehydes in the presence of NH2OH and alcoholic solvents under mild and one-pot reaction conditions. A plausible mechanism is proposed and discussed herein. In the overall reaction process, only water was generated as the byproduct. Various environmentally friendly reaction conditions are investigated for convenient transformationviathe (4C + 1C + 1N) annulation. This protocol provides a highly effective ring closureviathe formations of one carbon-carbon (C-C) bond, two carbon-nitrogen (C-N) bonds and one carbon-oxygen (C-O) bond.