61227-22-3Relevant academic research and scientific papers
POLYCYCLIC AMIDES AS UBE2K MODULATORS FOR TREATING CANCER
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Paragraph 00189-00191, (2021/07/10)
Provided are compounds of Formula (I) and pharmaceutically acceptable salts and compositions thereof, which are useful for treating conditions associated with modulation of UBE2K.
APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS AND USES THEREOF
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, (2019/04/09)
Described herein are ASK1 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of blood disease, autoimmune disorders, pulmonary disorders, hypertension, inflammatory diseases, fibrotic diseases, diabetes, diabetic nephropathy, renal diseases, respiratory diseases, cardiovascular diseases, acute lung injuries, acute or chronic liver diseases, and neurodegenerative diseases.
Macrocyclic pentamers functionalised around their periphery as potential building blocks
Nam, Seong,Ware, David C.,Brothers, Penelope J.
, p. 8389 - 8393 (2019/03/21)
The elaboration of a five-fold symmetric macrocyclic aromatic pentamer bearing peripheral benzyloxy and hydroxyl groups is described. These could be used to explore further functionalisation for use as pentagonal building blocks. The internal fluorine-substituted macrocycle has been prepared via a one-pot procedure which is an improvement on the stepwise chain growth approach reported in the literature.
BIARYL-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS
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Page/Page column 47; 48, (2014/10/15)
The present invention relates to compounds of the formula (I), wherein X, R, R1, R2, D, E1, E2, E3, E4, G1, G2, G3 and G4 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. They are inhibitors of the protease ca
Biaryl-propionic acid derivatives and their use as pharmaceuticals
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Paragraph 0128; 0129, (2014/10/16)
The present invention relates to compounds of the formula I, wherein X, R, R1, R2, D, E1, E2, E3, E4, G1, G2, G3 and G4 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. They are inhibitors of the protease cath
BIARYL-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS
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Page/Page column 47-48, (2014/10/15)
The present invention relates to compounds of the formula (I), wherein X, R, R1, R2, D, E1, E2, E3, E4, G1, G2, G3 and G4 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. They are inhibitors of the protease ca
Biaryl-Propionic Acid Derivatives and their Use as Pharmaceuticals
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Paragraph 0137; 0138; 0139, (2014/10/16)
The present invention relates to compounds of the formula I, wherein X, R, R1, R2, D, E1, E2, E3, E4, G1, G2, G3 and G4 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. They are inhibitors of the protease cath
THIOCHROMENE DERIVATIVES AS HIP HYDROXYLASE INHIBITORS
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Page/Page column 90, (2010/06/15)
The present invention relates to novel compounds, methods, and compositions capable of decreasing HEF hydroxylase enzyme activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF).
IMIDAZOPYRIDINE COMPOUNDS
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Page/Page column 23, (2010/04/23)
Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of formula (I) wherein the variables are as defined herein.
Conception of myeloperoxidase inhibitors derived from flufenamic acid by computational docking and structure modification
Van Antwerpen, Pierre,Prevost, Martine,Zouaoui-Boudjeltia, Karim,Babar, Sajida,Legssyer,Moreau, Patrick,Moguilevsky, Nicole,Vanhaeverbeek, Michel,Ducobu, Jean,Neve, Jean,Dufrasne, Francois
, p. 1702 - 1720 (2008/09/20)
The development of myeloperoxidase (MPO) inhibitors has been conducted using flufenamic acid as a lead compound. Computational docking of the drug and its analogs in the MPO active site was first attempted. Several molecules were then synthesized and assessed using three procedures for the measurement of their inhibiting activity: (i) the taurine assay, (ii) the accumulation of compound II, and (iii) the LDL oxidation by ELISA. Most of the synthesized molecules had an activity in the same range as flufenamic acid but none of them were able to inhibit the MPO-dependent LDL oxidation. The experiments however gave some useful indications for a rational conception of MPO inhibitors.
