87513-63-1Relevant articles and documents
New inhibitors of angiogenesis with antitumor activity in vivo
Marín-Ramos, Nagore I.,Alonso, Dulce,Ortega-Gutiérrez, Silvia,Ortega-Nogales, Francisco J.,Balabasquer, Moisés,Vázquez-Villa, Henar,Andradas, Clara,Blasco-Benito, Sandra,Pérez-Gómez, Eduardo,Canales, ángeles,Jiménez-Barbero, Jesús,Marquina, Ana,Del Prado, Jaime Moscoso,Sánchez, Cristina,Martín-Fontecha, Mar,López-Rodríguez, María L.
, p. 3757 - 3766 (2015)
Angiogenesis is a requirement for the sustained growth and proliferation of solid tumors, and the development of new compounds that induce a sustained inhibition of the proangiogenic signaling generated by tumor hypoxia still remains as an important unmet
Diversity-Oriented Synthesis of Spiroannulated Benzofuran-3-one Scaffold of Leptosphaerin C and Congeners via Aryne Insertion
Dhokale, Ranjeet A.,Mhaske, Santosh B.
, p. 4875 - 4882 (2017/05/12)
A concise synthesis of functionalized cyclohexenone-fused spirobenzofuran-3-ones under mild reaction conditions was developed. The reaction proceeds via insertion of aryne into the C-O bond followed by a regioselective intramolecular conjugate addition. The use of silyl-protected acid was crucial for the transformation. This protocol was successfully applied for the synthesis of leptosphaerin C core and its novel analogues.
CYCLIC PEROXIDE OXIDATION OF AROMATIC COMPOUND PRODUCTION AND USE THEREOF
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Page/Page column 10, (2014/10/15)
The present invention provides a method for converting an aromatic hydrocarbon to a phenol by providing an aromatic hydrocarbon comprising one or more aromatic C-H bonds and one or more activated C-H bonds in a solvent; adding a phthaloyl peroxide to the solvent; converting the phthaloyl peroxide to a di-radical; contacting the di-radical with the one or more aromatic C-H bonds; oxidizing selectively one of the one or more aromatic C-H bonds in preference to the one or more activated C-H bonds; adding a hydroxyl group to the one of the one or more aromatic C-H bonds to form one or more phenols; and purifying the one or more phenols.