6129-62-0Relevant articles and documents
Method for synthesizing beta-halogen tetrafluoroacyl fluoride
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Sheet 0012; 0013; 0014, (2017/08/29)
The invention discloses a method for synthesizing beta-halogen tetrafluoroacyl fluoride. The preparation method specifically comprises the following steps: adding an alkali halide and a catalyst into a drying reactor with a dry ice reflux condenser, placing the drying reactor in an ice water bath, slowly introducing hexafluoropropylene oxide with stirring, keeping the drying reactor in the ice water bath for 2h until no reflux exists at the bottom of the dry ice reflux condenser, continuing performing stirring for 2h, separating liquid with a liquid separation funnel, performing distillation under normal pressure, introducing gas produced in a distillation process into a cold trap for collection, and transferring the gas into a steel bottle to obtain liquid beta-halogen tetrafluoroacyl fluoride. The conversion rate of the raw material and the purity of a product are high, the purity of the product subjected to fractional distillation can reach 99 percent or higher, the product can chemically react with alcohol to obtain ester with purity of 99 percent, the production steps of the preparation method are simple and safe, and the preparation method is short in reaction time and high in productivity.
Reactions involving hexafluoropropylene oxide: Novel ring opening reactions and resolution of a racemic mixture of a bromofluoro ester, ultrasound mediated Reformatsky reactions and stereoselectivity
Coe, Paul L.,Loehr, Marianne,Rochin, Christophe
, p. 2803 - 2811 (2007/10/03)
A novel ring opening reaction of hexafluoropropylene oxide (HFPO) 1 with lithium bromide/zinc bromide and subsequent reaction of the resulting acyl fluoride with primary and secondary alcohols gave bromofluoro esters 2, 3, 4 and 7. Reaction of the corresponding acyl fluoride with water leads to acid 9 which on treatment with dehydroabietylamine 10 gave the diastereomeric salt 11. Resolution of 11 and subsequent hydrolysis and esterification reactions led to enantiomerically pure ester 12. Reformatsky reactions with 2 were studied which gave the alcohols 6 and 5. A Reformatsky reaction of 12 with formaldehyde afforded an alcohol 13 which is indicated by NMR spectroscopy in the presence of a chemical shift reagent to have proceeded stereoselectively.
EXCHANGE OF HALOGEN FOR FLUORINE IN REACTIONS OF VICINAL DIHALOPOLYFLUOROALKANES WITH CESIUM FLUORIDE
Cherstkov, V. F.,Postovoi, S. A.,Lantseva, D. T.,Sterlin, S. R.,Zeifman, Yu. V.,German, L. S.
, p. 2508 - 2511 (2007/10/02)
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