6130-75-2

Usage

Uses

Used in Environmental and Product Quality Control:
2,4,5-TRICHLOROANISOLE is used as a target for detection and removal in various industries to ensure product quality and safety. The primary reason for its detection is to prevent the musty, moldy odor and taste associated with cork taint in wine and other food products.
Used in Building Materials and Consumer Products Industry:
2,4,5-TRICHLOROANISOLE is used as a contaminant indicator for assessing the quality and safety of building materials and consumer products. The detection and minimization of TCA in these products help to prevent adverse health effects such as nausea, dizziness, and respiratory problems that may arise from exposure to this chemical compound.
Used in Research and Development:
2,4,5-TRICHLOROANISOLE is utilized as a subject of study in research aimed at understanding its formation, effects, and removal methods. This research is crucial for developing more effective strategies to mitigate the presence of TCA in various products and environments, thereby improving public health and product quality.

InChI:InChI=1/C7H5Cl3O/c1-11-7-3-5(9)4(8)2-6(7)10/h2-3H,1H3

Upstream product

• 95-94-3 1,2,4,5-tetrachlorobenzene 
• 124-41-4 sodium methylate 
• 1984-58-3 2,5-dichloroanisole 
• 64-19-7 acetic acid 
• 95-95-4 2,4,5-trichlorophenol 
• 77-78-1 dimethyl sulfate 
• 71-43-2 benzene 
• 583-78-8 2,5-dichlorophenol 
• 106-46-7 para-dichlorobenzene 
• 95-82-9 2,5 dichloroaniline 

Downstream Products

• 6282-18-4 3,3',5,5',6,6'-Hexachlor-2-hydroxy-2'-methoxy-diphenylmethan 
• 37138-84-4 3,4,6-trichloro-2-nitroanisole 
• 18113-13-8 2,4-dichloro-5-methoxyphenol 
• 95-95-4 2,4,5-trichlorophenol 
• 66015-90-5 2,3,5-trichloro-6-methoxyaniline 
• 244037-16-9 2,4,5-trichloro-3-iodoanisole 
• 244037-15-8 2,3,5-trichloro-4-iodo-6-methoxyaniline 
• 150-19-6 O-methylresorcine 
• 50375-04-7 1,3-dichloro-4,6-dimethoxybenzene 
• 14348-26-6 2,3,5-trichloro-6-hydroxy-benzenediazonium-betaine 
• 42138-72-7 Tetrachlor-o-anisidin 
• 858242-40-7 2,3,5-trichloro-6-methoxy-p-phenylenediamine 
• 857591-65-2 4-bromo-2,3,5-trichloro-6-methoxy-aniline 
• 857620-43-0 acetic acid-(2,3,5-trichloro-6-methoxy-anilide) 

Relevant academic research and scientific papers

THE REACTIONS OF UNACTIVATED ARYL HALIDES WITH SODIUM METHOXIDE IN HMPA; SYNTHESIS OF PHENOLS, ANISOLES, AND METHOXYPHENOLS

Sodium methoxide reacts with dichlorobenzenes in HMPA to give the chloroanisoles as a result of a SNAr process.Excess MeONa then effects the demethylation of the ethers to give the chlorophenols via an SN2 reaction.With tri- and tetrachlorobenzenes the initially formed chloroanisoles can be dealkylated to chlorophenols or can suffer further substitution to give the chlorodimethoxybenzenes; these react with excess MeONa to give the chloromethoxyphenols.The results obtained with the various isomers of the di-, tri-, and tetrachlorobenzenes are presented and discussed on the basis of the electronic effects of the substituents.

Nucleophilic Displacement in Polyhalogenoaromatic Compounds. Part 11. Kinetics of Protiodeiodination of Iodoarenes in Dimethyl Sulphoxide-Methanol

The rates of methoxide-ion induced protiodeiodination of a number of polychloroiodobenzenes and their derivatives have been measured in dimethyl sulphoxide-methanol (9:1 v/v; 323.2 K).The true reagent under these conditions appears to be the dimethyl sulphoxide anion, and the rates of reaction in some cases appear to approach that expected of a diffusion controlled process.This corresponds to a major decrease in the efficacy of further activating substituents in the aromatic system, altough deactivating groups such as p-OMe still show large effects.Chlorine promotes protiodeiodination in the order of efficiency o-Cl > m-Cl > p-Cl; the trifluoromethyl group activates displacement in the order o-CF3 > p-CF3 > m-CF3, although with much less difference between isomeric sites. o-Nitro-groups promote protiodeiodination whereas the p-nitro-group encourages methoxydeiodination.No evidence of methoxydeiodination was found in attack of the polychloroiodobenzenes, although the rates of methoxydechlorination of the corresponding polychlorobenzenes suggest that in some cases this might occur.Evidence rejecting the possible SRN1 mechanism and supporting nucleophilic attack by a carbanionic species upon iodine is presented.