61380-87-8

Upstream product

• 99-90-1 para-bromoacetophenone 
• 3490-92-4 methyl 2-cyano-3,3-bis(methylsulfanyl)acrylate 
• 1122-91-4 4-bromo-benzaldehyde 
• 17823-58-4 ethyl 2-cyano-3,3-di(methylsulfanyl)acrylate 
• 5147-80-8 [Bis(methylthio)methylene]malononitrile 

Downstream Products

• 94835-43-5 6-(4-bromophenyl)-2-oxo-4-(piperidin-1-yl)-2H-pyran-3-carbonitrile 
• 114388-31-7 6-(p-bromophenyl)-4-methylthio-2(1H)-pyridone 
• 114361-64-7 6-(p-bromophenyl)-4-methylthio-2-oxo-2H-pyran-3-carboxamide 
• 153391-40-3 2-(5-(4-bromophenyl)-1H-pyrazol-3-yl)acetonitrile 
• 200815-35-6 [3-(4-bromophenyl)-1-(4-methoxyphenyl)pyrazole-5-yl]acetonitrile 
• 326859-24-9 6-(4-Bromophenyl)-3-cyano-4-dimethylamino-2H-pyran-2-one 
• 391914-24-2 6-(4-bromophenyl)-2-oxo-4-(pyrrolidin-1-yl)-2H-pyran-3-carbonitrile 
• 391914-26-4 6-(4-bromophenyl)-4-[4-(2-methoxyphenyl)-1-piperazinyl]-2-oxo-2H-pyran-3-carbonitrile 
• 244216-91-9 3-(4-bromophenyl)-5-cyanomethyl-1-(4-fluorophenyl)pyrazole 
• 748815-94-3 [5-(4-bromophenyl)-8-(4-chlorobenzoyl)-2,3-dihydro-1H-imidazo[1,2-a]pyridin-7-ylidene]acetonitrile 

Relevant academic research and scientific papers

Synthesis, spectral characterization and photophysical studies of tetrahydroquinolines

A metal-free, ultrasound-assisted, fast synthesis of fluorescent N-Boc-protected 1,2,3,4–tetrahydroquinolines 9a-p is described through carbanion-induced ring transformation of 6-aryl-2H-pyran-2-ones 7 with tert?butyl 3-oxopiperidine-1-carboxylate 8 under

Design, synthesis, in vitro and in vivo biological evaluation of pyranone-piperazine analogs as potent antileishmanial agents

The current therapeutic regimen for visceral leishmaniasis is inadequate and unsatisfactory due to toxic side effects, high cost and emergence of drug resistance. Alternative, safe and affordable antileishmanials are, therefore, urgently needed and toward these we synthesized a series of arylpiperazine substituted pyranone derivatives and screened them against both in vitro and in vivo model of visceral leishmaniasis. Among 22 synthesized compounds, 5a and 5g showed better activity against intracellular amastigotes with an IC50 of 11.07 μM and 15.3 μM, respectively. In the in vivo, 5a significantly reduced hepatic and splenic amastigotes burden in Balb/c mice model of visceral leishmaniasis. On a mechanistic node, we observed that 5a induced direct Leishmania killing via mitochondrial dysfunction like cytochrome c release and loss of membrane potential. Taken together, our results suggest that 5a is a promising lead for further development of antileishmanial drugs.

Base-mediated alternate route for multi-functionalized allylbenzenes using ring transformation strategy

A simple yet innovative approach for the construction of multi-substituted allylbenzenes 14, 16 and 18 with ‘donor-acceptor’ functionalities has been delineated through base-mediated ring transformation of 6-aryl-2H-pyran-2-ones 13, 15 and 17 respectively

Transition metal-free synthesis of sterically hindered allylarenes from 5-hexene-2-one

A simple, efficient and transition metal-free strategy was established for the synthesis of highly functionalized, sterically hindered allylarenes (6, 7 & 8) by base-mediated ring transformation of 2-oxo-6-aryl-4-(methylthio/sec-amino)-2H-pyran-3-carbonit

Synthesis of Solution-Processable Donor-Acceptor Pyranone Dyads for White Organic Light-Emitting Devices

A series of donor-acceptor pyranones (3a-m, 4a-h) were synthesized using α-oxo-ketene-S,S-acetal as the synthon for their application as emissive materials for energy-saving organic light-emitting devices (OLEDs). Among them, five pyranones 3f, 3g, 3h, 3m

Base-promoted regioselective synthesis of 1,2,3,4-terahydroquinolines and quinolines from N-boc-3-piperidone

An efficient synthesis of 1,2,3,4-tetrahydroquinolines with donor and acceptor group has been delineated by base mediated ring transformation of 6-aryl-4-substituted-2H-pyran-2-one-3-carbonitriles by N-boc-3-piperidone followed by consecutive deprotection

Metal-Free Synthesis of Biaryl- and Teraryl-Cored Diarylmethanes by Ring Transformation of 2 H -Pyran-2-ones

An efficient metal-free approach for the synthesis of functionalized biaryl-cored diarylmethanes is described by the ring transformation of 2 H -pyran-2-ones using 4-phenylbutan-2-one as carbanion source. Moreover, 2 H -pyran-2-ones were reacted with 1,3-

First Dual Responsive “Turn-On” and “Ratiometric” AIEgen Probe for Selective Detection of Hydrazine Both in Solution and the Vapour Phase

A new dual responsive “turn-on” and “ratiometric” aggregation-induced emission luminogen (AIEgen) 3-formyl-5-(piperidin-1-yl)biphenyl-4-carbonitrile 6 a (FPBC 6 a) for selective detection of hydrazine in solution as well as in vapour phase is described. A

A Metal-Free Approach for the Synthesis of 2-Tetralones via Carbanion-Induced Ring Transformation of 2 H -Pyran-2-ones

A metal-free, ultrasound-assisted approach for the synthesis of highly functionalized 2-tetralones in high yields is described. The process involves ring transformation of 2 H -pyran-2-ones with the spirocyclic ketone 1,4-cyclohexandione monoethylene keta

Chemoselective synthesis of m-teraryls through ring transformation of 2 H-pyran-2-ones by 2-(1-arylethylidene)-malononitriles

We have developed a simple, efficient and chemoselective approach for the synthesis of m-teraryls by the reaction of 6-aryl-2-oxo-4-(sec.amino)-2H-pyran-3-carbonitriles and 2-(1-arylethylidene)malononitriles under basic conditions. We used 6-aryl-2-oxo-4-