614-35-7Relevant articles and documents
In-situ and one-step preparation of protein film in capillary column for open tubular capillary electrochromatography enantioseparation
Li, Ling,Xue, Xuqi,Zhang, Huige,Lv, Wenjuan,Qi, Shengda,Du, Hongying,Manyande, Anne,Chen, Hongli
supporting information, p. 2139 - 2142 (2021/04/07)
In this work, the phase-transitioned BSA (PTB) film using the mild and fast fabrication process adhered to the capillary inner wall uniformly, and the fabricated PTB film-coated capillary column was applied to realize open tubular capillary electrochromatography (OT-CEC) enantioseparation. The enantioseparation ability of PTB film-coated capillary was evaluated with eight pairs of chiral analytes including drugs and neurotransmitters, all achieving good resolution and symmetrical peak shape. For three consecutive runs, the relative standard deviations (RSD) of migration time for intra-day, inter-day, and column-to-column repeatability were in the range of 0.3%–3.5%, 0.2%–4.9% and 2.1%–7.7%, respectively. Moreover, the PTB film-coated capillary column ran continuously over 300 times with high separation efficiency. Therefore, the coating method based on BSA self-assembly supramolecular film can be extended to the preparation of other proteinaceous capillary columns.
Scavenger assisted combinatorial process for preparing libraries of amides, carbamates and sulfonamides
-
, (2008/06/13)
This invention relates to a novel solution phase process for the preparation of amide, carbamate, and sulfonamide combinatorial libraries. These libraries have utility for drug discovery and are used to form wellplate components of novel assay kits.
Direct separation and determination of synephrine enantiomers by high- performance liquid chromatography with electrochemical detection
Kusu,Matsumoto,Takamura
, p. 1158 - 1161 (2007/10/02)
High-performance liquid chromatography (HPLC) with electrochemical detection using a chiral ligand-exchange column (Sumichiral OA-5000) and a mobile aqueous phase containing 1 mM copper(II) acetate and 20 mM ammonium acetate (pH 6.4) was applied to the di