61424-26-8

Usage

Uses

Used in Pharmaceutical Industry:
3-Benzylaniline is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and medications. Its role in this industry is vital for creating active pharmaceutical ingredients and facilitating advancements in medical treatments.
Used in Dye Industry:
In the dye industry, 3-Benzylaniline is employed as a precursor in the production of different types of dyes. Its chemical properties make it suitable for creating a range of colorants used in various applications, including textiles, plastics, and printing inks.
Used in Organic Compounds Synthesis:
3-Benzylaniline is used as a building block in the synthesis of other organic compounds, playing a significant role in the creation of complex organic molecules for a wide array of applications across various industries. Its versatility in chemical reactions makes it an essential component in organic chemistry research and development.

InChI:InChI=1/C13H13N/c14-13-8-4-7-12(10-13)9-11-5-2-1-3-6-11/h1-8,10H,9,14H2

Upstream product

• 5840-41-5 1-benzyl-3-nitrobenzene 
• 2243-80-3 3-nitrobenzophenone 
• 7647-01-0 hydrogenchloride 
• 108-42-9 3-chloro-aniline 
• 100-44-7 benzyl chloride 
• 2835-78-1 3-amino benzophenone 
• 619-23-8 3-Nitrobenzyl chloride 
• 71-43-2 benzene 
• 619-25-0 3-Nitrobenzyl alcohol 
• 141883-38-7 2-chloro-5-nitro-benzophenone oxime 

Downstream Products

• 55251-23-5 3-Benzyltrifluoromethanesulfonanilid 
• 24796-14-3 2-[(3-Benzyl-phenylamino)-methylene]-malonic acid diethyl ester 
• 261-31-4 thioxanthene 
• 120454-34-4 2-mercaptodiphenylmethane 
• 120454-36-6 2-(allylthio)diphenylmethane 

Relevant academic research and scientific papers

One-pot borylation/Suzuki-Miyaura sp2-sp3 cross-coupling

We describe the first one-pot borylation/Suzuki-Miyaura sp2-sp3 cross-coupling between readily available aryl (pseudo)halides and activated alkyl chlorides. This method streamlines the synthesis of diaryl methanes, α-aryl carbonyls and allyl aryl compounds, substructures that are commonly found in life changing drug molecules.

Discovery of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors

Human sirtuin 2 (SIRT2) plays pivotal roles in multiple biological processes such as cell cycle regulation, autophagy, immune and inflammatory responses. Dysregulation of SIRT2 was considered as a main aspect contributing to several human diseases, including cancer. Development of new potent and selective SIRT2 inhibitors is currently desirable, which may provide a new strategy for treatment of related diseases. Herein, a structure-based optimization approach led to new 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as SIRT2 inhibitors. SAR analyses with new synthesized derivatives revealed a number of new potent SIRT2 inhibitors, among which 28e is the most potent inhibitor with an IC50 value of 42?nM. The selectivity analyses found that 28e has a very good selectivity to SIRT2 over SIRT1 and SIRT3. In cellular assays, 28e showed a potent ability to inhibit human breast cancer cell line MCF-7 and increase the acetylation of α-tubulin in a dose-dependent manner. This study will aid further efforts to develop highly potent and selective SIRT2 inhibitors for the treatment of cancer and other related diseases.

Novel SIRT2 protein inhibitor and usage thereof in pharmacy

The invention discloses a compound or salt, crystallographic form and solvate compounds of the compound acceptable in pharmacy, and the compound and the salt, crystallographic form, solvate compounds of the compound are shown as formula I, wherein X is selected from the formulas (please see the specifications for the formula); R1 is selected from aryl or ceteroary or substituted aryl or substituted ceteroary or from the formula (please see the specifications for the formula); R2 is selected from the formulas (please see the specifications for the formula); and R3 is selected from halogen or C1-C4 alkyl or C1-C4 alkoxy. The novel compound shown in formula I has the advantages that not only is good inhibitory activity achieved to SIRT2, but also the inhibiting effect is achieved to the tumor, and the novel compound has good pharmaceutical potentiality and provides a novel potential choice for the clinical medicament.

The unexpected desulfurization of 4-aminothiophenols

Thermolysis of 4-aminophenyl benzyl sulfide at 523 K in the hydrogen donor solvent (HDS), 9,10-dihydroanthracene (AnH2), gave 4-aminothiophenol and toluene as the predominant products of the homolytic S-C bond cleavage. Under these conditions, a portion of the 4-aminothiophenol was desulfurized to aniline with first-order kinetics and with a rate constant estimated by kinetic modeling to be 7.0 × 10-6 s-1. Starting with 4-NH2C6H4SH at 523 K, it was found that sulfur loss was more efficient in the non-HDSs, anthracene and hexadecane, than in AnH2. Under similar (competitive) reaction conditions, YC 6H4SHs with Y = H, 4-CN, and 3-CF3 were completely inert; with Y = 4-CH3O, there was some very minor desulfurization, whereas with Y = 4-N(CH3)2 and 4-N(CH3)(H), the sulfur extrusions were as fast as that for Y = 4-NH2. We tentatively suggest that this apparently novel reaction is a chain process initiated by the bimolecular formation of diatomic sulfur, S2, followed by a reversible addition of ground state, triplet 3S2 to the thiol sulfur atom, 4-NH2C 6H4S↑(SS↑)H, and insertion into the S-H bond, 4-NH2C6H4SSSH. In a cascade of reactions, aniline and S8 are formed with the chains being terminated by reaction of 4-NH2C6H4S↑(SS↑)H with 4-NH2C6H4SH. Such a reaction mechanism is consistent with the first-order kinetics. That this reaction is primarily observed with 4-YC6H4SH having Y = N(CH3) 2, N(CH3)(H), and NH2 is attributed to the fact that these compounds can exist as zwitterions.

MILD AND SIMPLE HYDROGENATION OF DIARYL OXIMES TO HYDROCARBONS USING AMMONIUM FORMATE-PALLADIUM ON CARBON

Various diaryl ketoximes have been reduced to the corresponding hydrocarbons under mild conditions using ammonium formate as the hydrogen source.

Substituted trifluoromethanesulfonanilides

Substituted trifluoromethanesulfonanilides wherein the anilide ring is bonded to a phenyl ring through a linking group selected from --CH2 --, --CH2 CH2 --, --CH(CH3)-- and EQU1 and pharmaceutically acceptable s