61448-99-5

Basic information

• Product Name: (+/-)-5-(2-hydroxy-2-phenylethyl)-3-methylisoxazole
• Synonyms: (+/-)-5-(2-hydroxy-2-phenylethyl)-3-methylisoxazole
• CAS NO: 61448-99-5
• Molecular Weight: 203.241
• Mol File: 61448-99-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (+/-)-5-(2-hydroxy-2-phenylethyl)-3-methylisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-5-(2-hydroxy-2-phenylethyl)-3-methylisoxazole(61448-99-5)
• EPA Substance Registry System: (+/-)-5-(2-hydroxy-2-phenylethyl)-3-methylisoxazole(61448-99-5)

Safety Data

• Hazardous Substances Data: 61448-99-5(Hazardous Substances Data)

Upstream product

• 300-87-8 3,5-dimethyl-1,2-oxazole 
• 100-52-7 benzaldehyde 
• 62759-26-6 ((3-methylisoxazol-5-yl)methyl)lithium 
• 27349-51-5 (3-methyl-5-isoxazolyl)methyl phenyl ketone 
• 100-47-0 benzonitrile 
• 123-54-6 acetylacetone 

Downstream Products

• 61449-25-0 5-Amino-1-hydroxy-1-phenyl-hexen-4-on-⁽³⁾ 
• 108401-87-2 5-hydroxy-1,7-diphenylhepta-1,4,6-trien-3-one 
• 51101-01-0 3-methyl-5-styryl-isoxazole 

Relevant articles and documents

Asymmetric transfer hydrogenation of heterocycle-containing acetophenone derivatives using N-functionalised [(benzene)Ru(II)(TsDPEN)] complexes

The application of enantiomerically-pure ruthenium(II) catalysts containing N - functionalised TsDPEN ligand to the asymmetric transfer hydrogenation of 15 examples of α-heterocyclic acetophenone derivatives is reported. Products of up to 99% ee were formed.

Structure-activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase

West Nile Virus (WNV) is a potentially deadly mosquito-borne flavivirus which has spread rapidly throughout the world. Currently there is no effective vaccine against flaviviral infections. We previously reported the identification of pyrazole ester derivatives as allosteric inhibitors of WNV NS2B-NS3 proteinase. These compounds degrade rapidly in pH 8 buffer with a half life of 1-2 h. We now report the design, synthesis and in vitro evaluation of pyrazole derivatives that are inhibitors of WNV NS2B-NS3 proteinase with greatly improved stability in the assay medium.

Lewis acid mediated addition of tri-n-butyl-stannylmethylisoxazole with aldehydes

Lewis acid mediated addition of 5-(tri-n-butylstannyl)methyl-3-methylisoxazole and its analogues with aldehydes have been carried out. Corresponding 5-(β-hydroxy)ethylisoxazoles were obtained in moderate yields, without ring opening of the isoxazole.