27349-51-5

Upstream product

• 300-87-8 3,5-dimethyl-1,2-oxazole 
• 100-47-0 benzonitrile 
• 93-58-3 benzoic acid methyl ester 
• 75632-83-6 3-methyl-5-[(trimethylsilyl)methyl]isoxazole 
• 141104-33-8 (E)-3-[(E)-2-(3-Methyl-isoxazol-5-yl)-1-phenyl-vinylamino]-acrylonitrile 
• 123-54-6 acetylacetone 

Downstream Products

• 7500-03-0 2-Methyl-6-phenyl-1,4-dihydropyridin-4-on 
• 61449-25-0 2-Amino-6-hydroxy-6-phenyl-2-hexen-4-on 
• 102720-77-4 1,3-Diphenyl-2-(3-methyl-5-isoxazolyl)-propan-1,3-dion 
• 102720-74-1 3-Methyl-5-(2-phenyl-1,3-dioxolan-2-yl)-methylisoxazol 
• 102720-92-3 3-Dimethylamino-1-phenyl-2-(3-methyl-5-isoxazolyl)-2-propenon 
• 497059-15-1 3-acetyl-5-(3-methyl-5-isoxazolyl)-4,6-diphenyl-2-pyridone 
• 881192-18-3 3-acetyl-6-isopropyl-5-(3-methyl-5-isoxazolyl)-4-phenyl-2-pyridone 
• 61448-99-5 (+/-)-5-(2-hydroxy-2-phenylethyl)-3-methylisoxazole 
• 102720-87-6 3,5-Diphenyl-4-(3-methyl-5-isoxazolyl)-isoxazol 
• 1469-95-0 1-phenylhexane-1,3,5-trione 
• 58369-46-3 (E)-6-phenyl-5-hexene-2,4-dione 

Relevant academic research and scientific papers

Asymmetric transfer hydrogenation of heterocycle-containing acetophenone derivatives using N-functionalised [(benzene)Ru(II)(TsDPEN)] complexes

The application of enantiomerically-pure ruthenium(II) catalysts containing N - functionalised TsDPEN ligand to the asymmetric transfer hydrogenation of 15 examples of α-heterocyclic acetophenone derivatives is reported. Products of up to 99% ee were formed.

Substituted enaminones, their derivatives and uses thereof

The present invention is related substituted enaminones represented by a compound of Formula I that are novel allosteric modulators of α7 nAChRs. The invention also discloses the treatment of disorders that are responsive to enhancement of acetylcholine a

Mo(CO)6-INDUCED N-O BOND CLEAVAGE OF ISOXAZOLES. A CONVENIENT ROUTE TO PYRIDIN-4(1H)-ONES

The Mo(CO)6-induced reaction of 3-methyl-5-(2-oxoalkyl)isoxazoles, which are derived through proton-abstraction of 3,5-dimethylisoxazole followed by treatment with esters, gave pyridin-4(1H)-ones in good to modest yields in a single step.

3,4-N,trisubstituted-4,5-dihydro-1H-pyrazole-1-carboxamides and their use as insecticides

3,4,N-Trisubstituted-4,5-dihydro-1H-pyrazole-1-carboxamide compounds wherein the substituent in the 4-position is a 5-membered heterocyclic ring moiety containing one ring oxygen or sulfur atom and one or two ring nitrogen atoms and the substituents in the 3-position and the N-position are optionally substituted phenyl moieties, such as 4,5-dihydro-3-(4-fluorophenyl)-N-(4-trifluoromethylphenyl)-4-(2-trifluoromethyl-5-thiazolyl)-1H-pyrazole-1-carboxamide were prepared from appropriate 3,4-disubstituted-4,5-dihydro-1H-pyrazole compounds, such as 4,5-dihydro-3-(4-fluorophenyl)-4-(2-trifluoromethyl-5-thiazolyl)-1H-pyrazole and phenyl isocyanates and isothiocyanates, such as 4-(trifluoromethyl)phenyl isocyanate. The compounds are insecticidal.

3,4-disubstituted-4,5-dihydro-1H-pyrazoles and a method of preparation

3,4-Diaryl-4,5-dihydro-1H-pyrazole compounds having a selected 5- or 6-membered aromatic heterocyclic moiety in the 4-position and an optionally substituted phenyl moiety in the 3-position, such as 4,5-dihydro-3-(4-fluorophenyl)-4-(5-trifluoromethyl-2-pyr

A NOVEL SYNTHESIS OF 4-METHYL-, 4-OXO-, AND 4-AMINO-3-(3-METHYL-5-ISOXAZOLYL)PYRIDINE DERIVATIVES VIA N-SILYL-1-AZA-ALLYL ANION

An N-silyl-aza-allyl anion (1) reacted with alkoxyalkenes (3a)-(3e) to afford the corresponding 4-methyl-pyridines (4a) and (4b), 4-pyridones (5c) and (5d), and 4-amino-pyridine (4e), possessing a 3-methyl-5-isoxazolyl group on C-3 atom, in 91, 90, 62, 27, and 68percent yields, respectively, whereas alkoxyalkenes (3f) and (3g) gave the corresponding N-adduct intermediates (6f) and (6g) in 46 and 60percent yields.

Preparation of N-Silyl-enamines from α-Silyl Carbanions and Aromatic Nitriles

The preparations of seven N-silyl-enamines (1a) - (1g) and their chemical behaviour are reported.Lithiated 4-(trimethylsilylmethyl)pyridine (2b) easily reacted with benzonitrile (4a) in tetrahydrofuran to give only (E)-1-phenyl-2-(4-pyridyl)-1-(trimethylsilylamino)ethene (1b) in 90percent yield.On the other hand, lithiated t-butyl trimethylsilylacetate (2c) did not react with (4a) at all, but reacted readily with 2- or 4-cyanopyridines, (4b) or (4c), and scarcely at all reacted with 3-cyanopyridine (4d) to give the corresponding t-butyl (Z)-3-trimethylsilylamino-3-pyridylpropenoates (1c), (1d), and (1e) in 68, 75, and 4percent yields, respectively.The reaction of 3-methyl-5-(trimethylsilylmethyl)isoxazole (2d) with the nitriles (4a) or (4b) gave the corresponding N-silyl-enamine (1g) or the desilylated enamines (5b,c), which were unstable and were readily hydrolyzed to the corresponding ketones (6a) or (6b).