61449-25-0Relevant academic research and scientific papers
Structure-activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase
Sidique, Shyama,Shiryaev, Sergey A.,Ratnikov, Boris I.,Herath, Ananda,Su, Ying,Strongin, Alex Y.,Cosford, Nicholas D.P.
scheme or table, p. 5773 - 5777 (2010/04/30)
West Nile Virus (WNV) is a potentially deadly mosquito-borne flavivirus which has spread rapidly throughout the world. Currently there is no effective vaccine against flaviviral infections. We previously reported the identification of pyrazole ester derivatives as allosteric inhibitors of WNV NS2B-NS3 proteinase. These compounds degrade rapidly in pH 8 buffer with a half life of 1-2 h. We now report the design, synthesis and in vitro evaluation of pyrazole derivatives that are inhibitors of WNV NS2B-NS3 proteinase with greatly improved stability in the assay medium.
Polycarbonylmethyl Derivatives: Reactions of 2-(3-Methyl-5-isoxazolyl)-1-phenylethanone
Eiden, Fritz,Patzelt, Gertrud
, p. 242 - 251 (2007/10/02)
Starting with the compound 11, the isoxazole derivatives 22a and 27a are synthesized.These compounds are transformed to the substituted isoxazoles 23, 25 and 28.Catalytic hydrogenation of the isoxazol derivatives 11, 15 and 23 gives the 1,3,5-tricarbonyl
