61494-55-1

Basic information

• Product Name: 2-Chloro-3-pyridineacetic acid
• Synonyms: 2-Chloro-3-pyridineacetic acid;2-CHLORO-PYRIDINE-3-YL-ACETIC ACID;2-Chloropyridine-3-acetic acid;(2-Chloropyridin-3-yl)acetic acid 95+%;3-(Carboxymethyl)-2-chloropyridine;2-(2-chloropyridin-3-yl)acetic acid;(2-CHLORO-PYRIDIN-3-YL)-ACETIC ACID
• CAS NO: 61494-55-1
• Molecular Formula: C₇H₆ClNO₂
• Molecular Weight: 171.58
• Product Categories: pharmacetical
• Mol File: 61494-55-1.mol
• Article Data: 14

Chemical Properties

• Melting Point: 203-204 °C(Solv: benzene (71-43-2))
• Boiling Point: 336.6oC at 760 mmHg
• Flash Point: 157.4oC
• Appearance: /
• Density: 1.405g/cm3
• Vapor Pressure: 4.34E-05mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.79±0.10(Predicted)
• CAS DataBase Reference: 2-Chloro-3-pyridineacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-3-pyridineacetic acid(61494-55-1)
• EPA Substance Registry System: 2-Chloro-3-pyridineacetic acid(61494-55-1)

Safety Data

• Hazardous Substances Data: 61494-55-1(Hazardous Substances Data)

Usage

Description

2-Chloro-3-pyridineacetic acid is an organic compound with the chemical formula C6H4ClNO2. It is a derivative of pyridineacetic acid, featuring a chloro substituent at the 2nd position and a carboxyl group at the 3rd position. 2-Chloro-3-pyridineacetic acid has potential applications in various fields, particularly in the pharmaceutical industry.

Uses

Used in Pharmaceutical Industry:
2-Chloro-3-pyridineacetic acid is used as a chemical intermediate for the synthesis of RORγ agonists, which are a class of compounds that target the Retinoid-Related Orphan Receptor Gamma. These agonists have potential therapeutic applications in the treatment of cancer, as they can modulate the activity of the RORγ receptor and influence various cellular processes related to cancer progression and immune response.

Physical Form

Solid

InChI:InChI=1/C7H6ClNO2/c8-7-5(4-6(10)11)2-1-3-9-7/h1-3H,4H2,(H,10,11)

Upstream product

• 40134-18-7 methyl 2-chloropyridine-3-carboxylate 
• 166770-75-8 (2-chloropyridin-3-yl)methyl methanesulfonate 
• 286836-24-6 (7-bromobenzofuran-5-yl)methanol 
• 42330-59-6 (2-chloropyrid-3-yl)methanol 
• 89581-84-0 2-chloro-3-(chloromethyl)pyridine 
• 773837-37-9 sodium cyanide 
• 6959-48-4 3-chloromethylpyridinium chloride 
• 6635-88-7 3-(cyanomethyl)pyridine 1-oxide 
• 6443-85-2 3-pyridinylacetonitrile 
• 101012-32-2 2-(2-chloropyridin-3-yl)acetonitrile 

Downstream Products

• 6419-36-9 3-pyridineacetic acid hydrochloride 
• 1202067-21-7 3-[(2,2-dimethyltetrahydro-5H-[1,3]dioxolo[4,5-c]pyrrol-5-yl)carbonyl]-N-(2-fluoro-4-iodophenyl)thieno[2,3-b]pyridin-2-amine 
• 1202067-35-3 (cis-3,4-dihydroxypyrrolidin-1-yl)-[2-(2-fluoro-4-iodophenylamino)thieno[2,3-b]pyridin-3-yl]methanone 
• 1202066-93-0 5-[2-(2-fluoro-4-iodophenylamino)thieno[2,3-b]pyridine-3-carbonyl]-3-methyl-hexahydropyrrolo[3,4-d]oxazol-2-one 
• 1202066-95-2 (3aR,6aS)-5-[2-(2-fluoro-4-iodophenylamino)thieno[2,3-b]pyridine-3-carbonyl]-tetrahydro[1,3]dioxolo[4,5-c]pyrrol-2-one 
• 1202067-94-4 [(3S,4S)-3-amino-4-hydroxypyrrolidin-1-yl]-[2-(2-fluoro-4-iodophenylamino)thieno[2,3-b]pyridin-3-yl]-methanone 
• 1202067-39-7 [(3R,4S)-3-amino-4-hydroxypyrrolidin-1-yl]-[2-(2-fluoro-4-iodophenylamino)thieno[2,3-b]pyridin-3-yl]-methanone 
• 1202067-89-7 [(3S,4R)-3-amino-4-hydroxypyrrolidin-1-yl]-[2-(2-fluoro-4-iodophenylamino)thieno[2,3-b]pyridin-3-yl]-methanone 
• 1202068-00-5 [2-(2-fluoro-4-iodophenylamino)thieno[2,3-b]pyridin-3-yl]-[(3S,4S)-3-hydroxy-4-(methylamino)pyrrolidin-1-yl]-methanone 
• 1202067-18-2 [2-(2-fluoro-4-iodophenylamino)thieno[2,3-b]pyridin-3-yl]-[(4aS,7aR)-hexahydropyrrolo[3,4-b][1,4]oxazin-6-yl]-methanone 
• 1202067-23-9 5-[2-(2-fluoro-4-iodophenylamino)thieno[2,3-b]pyridine-3-carbonyl]tetrahydropyrrolo[3,4-c]pyrrole-1,3-dione 
• 1202067-29-5 (3aS,6aR)-5-[2-(2-fluoro-4-iodophenylamino)thieno[2,3-b]pyridine-3-carbonyl]-3-(methyl)hexahydropyrrolo[3,4-d]oxazol-2-one 
• 1202067-13-7 N-(2-fluoro-4-iodophenyl)-3-[(2-methyl-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)carbonyl] thieno[2,3-b]pyridin-2-amine 
• 1202067-04-6 N-(2-fluoro-4-iodophenyl)-3-{[cis-(3,6)-2-methyl-3a,4,6,6a-tetrahydropyrrolo[3,4-d]imidazol-5(1H)-yl]carbonyl}thieno[2,3-b]pyridin-2-amine 

Relevant articles and documents

TOPICAL FORMULATIONS

Provided herein are gelled topical formulations for the treatment of skin diseases comprising: a) a MEK inhibitor; b) one or more organic solvents in an amount of about 70% to about 99% by weight; and c) a gelling agent; wherein the one or more organic solvents are selected from the group consisting of C2-6 alcohol, a C2-6 alkylene glycol, a di-(C2-6 alkylene) glycol, a polyethylene glycol, C1-3 alkyl-(OCH2CH2)1-5-OH, DMSO, ethyl acetate, acetone, N-methyl pyrrolidone, benzyl alcohol, glycerin, and an oil; the gelling agent is hydroxypropyl cellulose having a molecular weight ranging from about 40,000 Dato about 2,500,000 Da; and wherein the gelled topical formulation has a viscosity of from 1 to 25,000 cps; and DMSO, when present, is combined with at least one other of said organic solvents such that DMSO is present in an amount of less than 50% by weight.

ARYL-ANILINE AND HETEROARYL-ANILINE COMPOUNDS FOR TREATMENT OF BIRTHMARKS

Provided herein are compounds and pharmaceutical compositions thereof for treating a birthmark in a subject in need thereof, wherein the compound is according to any one of formula (1), (II), (III), (IV), and (V). wherein X1, X2, X3, R1, R2, R2a, R13, R13a, R23, R23a, R23b, R33, R33a, R33b, R43, R43a, R51, R53, R53a, R53b, bond "a", and subscript n are described herein.

Preparation method of 3-pyridylacetic acid hydrochloride

The invention discloses a preparation method of 3-pyridylacetic acid hydrochloride and belongs to the field of chemistry. A 3-pyridylacetic acid hydrochloride product is prepared from 3-methylpyridine chlorination side product 2-chloro-3-methylpyridine as a raw material through cyanidation, alkaline hydrolysis, hydrogenation reduction and salification. The 3-pyridylacetic acid hydrochloride product has purity of 98.5% or more.