6161-86-0Relevant articles and documents
Preparation method of phenoxycarboxylic acid substances
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Paragraph 0051; 0052; 0053, (2019/01/08)
The invention provides a preparation method of phenoxycarboxylic acid substances, wherein the preparation method includes the steps: S1) mixing phenol compounds represented by the formula (I) and halogenated fatty alcohols represented by the formula (II) with alkali metal carbonates in organic solvents, carrying out heating reaction to obtain phenoxy fatty alcohols; S2) carrying out reaction of the phenoxy fatty alcohols with oxidants to obtain phenoxy fatty acids; and S3) carrying out mixed reaction of the phenoxy fatty alcohols, a chlorination catalyst and a chlorinating agent to obtain thephenoxycarboxylic acid substances represented by the formula (III). Compared with the prior art, the phenoxy fatty alcohols are obtained with phenolic compounds as the starting raw material, and thenoxidized and chlorinated to obtain the phenoxycarboxylic acid compounds. The method does not need dehydration, is environmentally friendly, has no chlorophenol participation, cannot produce dioxins, solves the problem of large odor, and has high selectivity for directional chlorination. At the same time, the method does not need cumbersome enrichment devices. The whole process is simple, the investment of equipment is low, and the energy consumption is reduced.
Copper(ii)-catalyzed C-O coupling of aryl bromides with aliphatic diols: Synthesis of ethers, phenols, and benzo-fused cyclic ethers
Liu, Yajun,Park, Se Kyung,Xiao, Yan,Chae, Junghyun
supporting information, p. 4747 - 4753 (2014/06/24)
A highly efficient copper-catalyzed C-O cross-coupling reaction between aryl bromides and aliphatic diols has been developed employing a cheaper, more efficient, and easily removable copper(ii) catalyst. A broad range of aryl bromides were coupled with aliphatic diols of different lengths using 5 mol% CuCl2 and 3 equivalents of K2CO3 in the absence of any other ligands or solvents to afford the corresponding hydroxyalkyl aryl ethers in good to excellent yields. In this newly developed protocol, aliphatic diols have multilateral functions as coupling reactants, ligands, and solvents. The resulting hydroxyalkyl aryl ethers were further readily converted into the corresponding phenols, presenting a valuable alternative way to phenols from aryl bromides. Furthermore, it was demonstrated that they are useful intermediates for more advanced molecules such as benzofurans and benzo-fused cyclic ethers. This journal is
Fluorophosphonate derivatives of N9-benzylguanine as potent, slow-binding multisubstrate analogue inhibitors of purine nucleoside phosphorylase
Halazy,Ehrhard,Eggenspiller,Berges-Gross,Danzin
, p. 177 - 184 (2007/10/02)
The phosphonate derivatives of N9-benzylguanine (4a-4h) have been prepared as purine nucleoside phosphorylase inhibitors. Enzyme inhibition studies with PNP from calf spleen or human erythrocyte show that compounds 4b and 4c are among the best PNP inhibitors ever reported, demonstrating further the importance of fluorines in such type of inhibitors.
