62006-19-3

Basic information

• Product Name: 2-(4-Chlorophenyl)-1-(p-tolyl)ethanone
• Synonyms: 2-(4-Chlorophenyl)-1-(p-tolyl)ethanone;2-(4-Chlorophenyl)-4'-methylacetophenone;2-(4-chlorophenyl)-1-(4-methylphenyl)ethanone
• CAS NO: 62006-19-3
• Molecular Formula: C₁₅H₁₃ClO
• Molecular Weight: 244.71612
• Mol File: 62006-19-3.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-Chlorophenyl)-1-(p-tolyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Chlorophenyl)-1-(p-tolyl)ethanone(62006-19-3)
• EPA Substance Registry System: 2-(4-Chlorophenyl)-1-(p-tolyl)ethanone(62006-19-3)

Safety Data

• Hazardous Substances Data: 62006-19-3(Hazardous Substances Data)

Usage

General Description

2-(4-Chlorophenyl)-1-(p-tolyl)ethanone, also known as 4'-Chloroacetophenone, is a chemical compound with the molecular formula C14H11ClO. It is a substituted acetophenone, which is a type of organic compound widely used in the production of pharmaceuticals, fragrances, and other fine chemicals. This specific compound is widely used as an intermediate in the synthesis of various pharmaceuticals, especially those with analgesic or anti-inflammatory properties. It is also used in the production of perfumes and flavoring agents. Due to its chemical structure, it is considered to be a potentially harmful and irritating substance, and proper safety precautions should be followed when handling it.

Upstream product

• 108-88-3 toluene 
• 25026-34-0 4-chlorophenacetyl chloride 
• 201230-82-2 carbon monoxide 
• 624-31-7 4-tolyl iodide 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 7179-73-9 2-(4-chlorophenyl)-1-(p-tolyl)ethanol 
• 5142-75-6 tri(p-tolyl)bismuth 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 140-53-4 p-chlorobenzyl cyanide 
• 26037-50-3 tri(4-chloro)benzyl aluminium 
• 104-87-0 4-methyl-benzaldehyde 
• 1878-66-6 4-chlorophenylacetic Acid 
• 99-75-2 4-methyl-benzoic acid methyl ester 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 1041810-86-9 (Z)-3-chloro-2-(4-chlorophenyl)-3-(p-tolyl)propenal 
• 1221155-43-6 3-(azepan-1-yl)-2-(4-chlorophenyl)-1-(4-methylphenyl)propan-1-one 
• 343596-22-5 2-bromo-2-(4-chlorophenyl)-1-(4-methylphenyl)ethanone 
• 1416728-01-2 N-(2-(4-chlorophenyl)-1-p-tolylethylidene)-4-methoxyaniline 
• 1416727-81-5 N-(2-(4-chlorophenyl)-1-p-tolylethyl)-4-methoxyaniline 
• 86508-29-4 1-(4-chlorophenyl)-2-(4-methylphenyl)ethane-1,2-dione 
• 77989-07-2 3-p-chlorophenyl-4-p-tolyl-1,2,5-thiadiazole 

Relevant articles and documents

An Oxidant- And Catalyst-Free Synthesis of Dibenzo[ a, c ]carbazoles via UV Light Irradiation of 2,3-Diphenyl-1 H -indoles

An efficient methodology for the synthesis of dibenzo[a,c]- carbazoles via annulation of 2,3-diphenyl-1H-indoles in EtOH under UV light irradiation (λO = 365 nm) along with hydrogen evolution is described. This method exhibits the advantages of mild reaction conditions, no requirement of any oxidants and catalysts, and release of hydrogen as the only byproduct. Notably, the mechanism investigation confirms that the trans-4b,8a-dihydro-9H-dibenzo[a,c]carbazole intermediate could convert into cis-4b,8a-dihydro-9H-dibenzo[a,c]carbazole, which relies on the nitrogen atom of the indole ring. This is followed by intramolecular dehydrogenation which yields the dibenzo[a,c]carbazoles. 2021. Thieme. All rights reserved.

Vicinal diaryl azole-based urea derivatives as potential cholesterol lowering agents acting through inhibition of SOAT enzymes

A novel series of vicinal diaryl azole-urea derivatives were synthesized and evaluated for their potential to inhibit SOAT enzyme. Among the reported compounds, compound (12d) emerged as the most potent compound with an IC50value of 2.43?μM. In polaxamer-407 induced lipoprotein lipase inhibition model, compound (12d) reduced triglyceride turnover in?vivo. Compound (12d) also showed dose-dependent prevention of serum total cholesterol and prevention of LDL-C elevation at a dose of 30?mg/kg. Furthermore, compound (12d) showed potential to stop falling levels of serum HDL-C dose-dependently and improved the atherogenic index. Effect of 12d on body weight, plaque formation and development of atherogenic lesions were studied. Toxicological study of compound (12d) indicated that at a dose of 2000?mg/kg, 12d was devoid of any signs of toxicity or mortality.

Tandem nucleophilic addition-Oppenauer oxidation of aromatic aldehydes to aryl ketones with triorganoaluminium reagents

In the presence of pinacolone, the in situ prepared triorganoaluminium reagents reacted with aromatic aldehydes to give ketones in moderate to high yield. We propose that the products are formed via a tandem organoaluminium reagents addition-Oppenauer oxidation sequence. The Royal Society of Chemistry 2013.