62006-19-3

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-Chlorophenyl)-1-(p-tolyl)ethanone is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of medications with analgesic or anti-inflammatory properties. Its role in the production of these drugs is crucial, as it aids in the creation of effective treatments for pain and inflammation.
Used in Perfumery and Flavoring Industry:
In the realm of perfumes and flavoring agents, 2-(4-Chlorophenyl)-1-(p-tolyl)ethanone is utilized for its distinctive aromatic properties, enhancing the fragrances and tastes of various consumer products. Its contribution to these industries is significant, as it helps in crafting unique and appealing scents and flavors.
Given the potential hazards associated with 2-(4-Chlorophenyl)-1-(p-tolyl)ethanone, it is imperative that safety measures are strictly followed in all applications to ensure the well-being of those handling the compound and the environment.

Upstream product

• 108-88-3 toluene 
• 25026-34-0 4-chlorophenacetyl chloride 
• 104-88-1 4-chlorobenzaldehyde 
• 104-85-8 para-methylbenzonitrile 
• 201230-82-2 carbon monoxide 
• 624-31-7 4-tolyl iodide 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 7179-73-9 2-(4-chlorophenyl)-1-(p-tolyl)ethanol 
• 5142-75-6 tri(p-tolyl)bismuth 
• 26037-50-3 tri(4-chloro)benzyl aluminium 
• 104-87-0 4-methyl-benzaldehyde 
• 1878-66-6 4-chlorophenylacetic Acid 
• 99-75-2 4-methyl-benzoic acid methyl ester 
• 824-79-3 sodium 4-methylbenzenesulfinate 

Downstream Products

• 86508-29-4 1-(4-chlorophenyl)-2-(4-methylphenyl)ethane-1,2-dione 
• 1041810-86-9 (Z)-3-chloro-2-(4-chlorophenyl)-3-(p-tolyl)propenal 
• 1221155-43-6 3-(azepan-1-yl)-2-(4-chlorophenyl)-1-(4-methylphenyl)propan-1-one 
• 343596-22-5 2-bromo-2-(4-chlorophenyl)-1-(4-methylphenyl)ethanone 
• 1416728-01-2 N-(2-(4-chlorophenyl)-1-p-tolylethylidene)-4-methoxyaniline 
• 1416727-81-5 N-(2-(4-chlorophenyl)-1-p-tolylethyl)-4-methoxyaniline 
• 77989-07-2 3-p-chlorophenyl-4-p-tolyl-1,2,5-thiadiazole 

Relevant academic research and scientific papers

An Oxidant- And Catalyst-Free Synthesis of Dibenzo[ a, c ]carbazoles via UV Light Irradiation of 2,3-Diphenyl-1 H -indoles

An efficient methodology for the synthesis of dibenzo[a,c]- carbazoles via annulation of 2,3-diphenyl-1H-indoles in EtOH under UV light irradiation (λO = 365 nm) along with hydrogen evolution is described. This method exhibits the advantages of mild reaction conditions, no requirement of any oxidants and catalysts, and release of hydrogen as the only byproduct. Notably, the mechanism investigation confirms that the trans-4b,8a-dihydro-9H-dibenzo[a,c]carbazole intermediate could convert into cis-4b,8a-dihydro-9H-dibenzo[a,c]carbazole, which relies on the nitrogen atom of the indole ring. This is followed by intramolecular dehydrogenation which yields the dibenzo[a,c]carbazoles. 2021. Thieme. All rights reserved.

Cobalt(II)-Catalyzed Stereoselective Olefin Isomerization: Facile Access to Acyclic Trisubstituted Alkenes

Stereoselective synthesis of trisubstituted alkenes is a long-standing challenge in organic chemistry, due to the small energy differences between E and Z isomers of trisubstituted alkenes (compared with 1,2-disubstituted alkenes). Transition metal-catalyzed isomerization of 1,1-disubstituted alkenes can serve as an alternative approach to trisubstituted alkenes, but it remains underdeveloped owing to issues relating to reaction efficiency and stereoselectivity. Here we show that a novel cobalt catalyst can overcome these challenges to provide an efficient and stereoselective access to a broad range of trisubstituted alkenes. This protocol is compatible with both mono- and dienes and exhibits a good functional group tolerance and scalability. Moreover, it has proven to be a useful tool to construct organic luminophores and a deuterated trisubstituted alkene. A preliminary study of the mechanism suggests that a cobalt-hydride pathway is involved in the reaction. The high stereoselectivity of the reaction is attributed to both a π-πstacking effect and the steric hindrance between substrate and catalyst.

Vicinal diaryl azole-based urea derivatives as potential cholesterol lowering agents acting through inhibition of SOAT enzymes

A novel series of vicinal diaryl azole-urea derivatives were synthesized and evaluated for their potential to inhibit SOAT enzyme. Among the reported compounds, compound (12d) emerged as the most potent compound with an IC50value of 2.43?μM. In polaxamer-407 induced lipoprotein lipase inhibition model, compound (12d) reduced triglyceride turnover in?vivo. Compound (12d) also showed dose-dependent prevention of serum total cholesterol and prevention of LDL-C elevation at a dose of 30?mg/kg. Furthermore, compound (12d) showed potential to stop falling levels of serum HDL-C dose-dependently and improved the atherogenic index. Effect of 12d on body weight, plaque formation and development of atherogenic lesions were studied. Toxicological study of compound (12d) indicated that at a dose of 2000?mg/kg, 12d was devoid of any signs of toxicity or mortality.

Design and synthesis of 4,5-diaryl/heteroarylthiophene-2-carboxylic acid derivatives and evaluation of their biological activities

Synthesis, characterization and biological activity of novel 4,5-diaryl/heteroaryl thiophene-2-carboxylic acid derivatives are described. Aryl/heteroaryl esters were converted to substituted thiophene esters via a Vilsmeier-Haack reaction, which were then hydrolyzed to 4,5-diaryl/heteroaryl thiophene-2-carboxylic acid derivatives 8a-h. All products were characterized by 1H NMR, 13C NMR, IR and MS. Antibacterial activity of the synthesized compounds against two Gram-positive and two Gram-negative bacteria, as well as their anticancer activity against PC-3 cell line (human prostate cancer cell lines) were evaluated.

Tandem nucleophilic addition-Oppenauer oxidation of aromatic aldehydes to aryl ketones with triorganoaluminium reagents

In the presence of pinacolone, the in situ prepared triorganoaluminium reagents reacted with aromatic aldehydes to give ketones in moderate to high yield. We propose that the products are formed via a tandem organoaluminium reagents addition-Oppenauer oxidation sequence. The Royal Society of Chemistry 2013.

Direct synthesis of aryl ketones by palladium-catalyzed desulfinative addition of sodium sulfinates to nitriles

Mild yet direct: A convenient and efficient method for the synthesis of various aryl ketones by palladium-catalyzed desulfinative addition of aromatic sulfinic acid sodium salts to various nitriles is described (see scheme). Aromatic and aliphatic nitriles are successfully reacted with arenesulfinic acid sodium salts to form aryl ketones in good yields.

Pd-catalyzed synthesis of α-aryl ketones through couplings of α-arylacetyl chlorides with triarylbismuths as multi-coupling nucleophiles

The cross-coupling reaction of α-arylacetyl chlorides with triarylbismuths was studied under Pd-catalyzed conditions. The reaction was found to be facile under the established protocol and furnished high yields of α-aryl ketones in short reaction times. T

Investigations concerning the COX/5-LOX inhibiting and hydroxyl radical scavenging potencies of novel 4,5-diaryl isoselenazoles

The aim of this study was to investigate 4,5-diaryl isoselenazoles as multiple target non-steroidal anti-inflammatory drugs (MTNSAIDs) which can intervene into the inflammatory processes via different mechanisms of action creating a new class of compounds

Synthesis, antileukemic and antiplatelet activities of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines

The synthesis, antileukemic and antiplatelet activity evaluation of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines are described. In general, it was found that compound 17o showed moderate antileukemic activity against MOLT3 human leukemic cancer cell lines. An arachidonic acid induced platelet aggregation effect on washed rat platelets was studied. Compound 17i was found to be the most potent. The antiplatelet properties may be mediated by interference with the arachidonic acid pathway.