69193-15-3

Basic information

• Product Name: L-Leucinamide, N-[(phenylmethoxy)carbonyl]glycyl-L-phenylalanyl-
• CAS NO: 69193-15-3
• Molecular Formula: C25H32N4O5
• Molecular Weight: 468.553
• Mol File: 69193-15-3.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: L-Leucinamide, N-[(phenylmethoxy)carbonyl]glycyl-L-phenylalanyl-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Leucinamide, N-[(phenylmethoxy)carbonyl]glycyl-L-phenylalanyl-(69193-15-3)
• EPA Substance Registry System: L-Leucinamide, N-[(phenylmethoxy)carbonyl]glycyl-L-phenylalanyl-(69193-15-3)

Safety Data

• Hazardous Substances Data: 69193-15-3(Hazardous Substances Data)

Upstream product

• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 35909-92-3 N-carbobenzoxy-L-phenylalanine methyl ester 
• 69193-13-1 Cbz-L-Phe-L-Leu-NH₂ 
• 687-51-4 H-L-Leu-NH₂ 
• 1170-76-9 Z-Gly-(L)-Phe 
• 10466-61-2 (2S)-amino-4-methylpentanamide hydrochloride 
• 114006-17-6 Z-Gly-L-Phe-O-carbamoylmethyl 
• 169676-29-3 Z-Gly-L-Phe-O-CH₂CF₃ 
• 6206-42-4 N-benzyloxycarbonylglycyl-L-phenylalanine methyl ester 
• 1145-81-9 ethyl 2-(benzyloxycarbonylamino)ethanoate 
• 38678-59-0 L-Phe-L-Leu-NH₂ 

Downstream Products

• 84969-56-2 Z-Gly-Gly-L-Phe-L-Leu-NH₂ 
• 82948-92-3 [des-tyr¹]-leucine enkephalinamide 
• 71591-21-4 Z-Tyr-Gly-Gly-Phe-Leu-NH₂ 
• 71591-20-3 H-Gly-Phe-Leu-NH₂ 

Relevant articles and documents

Kinetically controlled peptide synthesis mediated by papain using the carbamoylmethyl ester as an acyl donor

A series of dipeptides were synthesized generally in good yields with carbamoylmethyl (Cam) esters as acyl donors in the presence of a cysteine protease, papain, immobilized on Celite. Several segment condensations were also achieved generally in high yields without danger of racemization and formation of the secondary-hydrolysis product. Moreover, partial sequences of some bioactive peptides were prepared through segment condensations, and aimed-at peptides were obtained generally in high yields without the racemization of C-terminal residues of the carboxyl components. Thus, the superiority of the Cam ester in the kinetically controlled peptide synthesis was once again ascertained in couplings mediated by the cysteine protease as in those catalyzed by the serine proteases reported earlier.

Superiority of the carbamoylmethyl ester as an acyl donor for the protease-catalyzed kinetically controlled peptide synthesis in organic media: Application to segment condensations

The superiority of the carbamoylmethyl ester as an acyl donor for the α-chymotrypsin-catalyzed kinetically controlled peptide synthesis was demonstrated in several segment condensations carried out in organic media with low water content. Then this approach was successfully applied to the construction of the Leuenkephalin sequence via the 4 + 1 segment condensation.

Continuous synthesis of a tripeptide by successive condensation and transesterification catalyzed by two immobilized proteinases in organic solvent.

The tripeptide Z-GlyPheLeuNH2 was continuously synthesized in a high yield from three amino acid derivatives, Z-Gly, PheOMe, and LeuNH2, by immobilized thermolysin (IMT) and immobilized alpha-chymotrypsin (IMC) in an organic solvent, ethyl acetate. The op