6228-39-3

Basic information

• Product Name: 1-(4-methylpentan-2-ylidene)-2-phenylhydrazine
• CAS NO: 6228-39-3
• Molecular Formula: C₁₂H₁₈N₂
• Molecular Weight: 190.2847
• Mol File: 6228-39-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 275.3°C at 760 mmHg
• Flash Point: 120.3°C
• Density: 0.93g/cm³
• Vapor Pressure: 0.00514mmHg at 25°C
• Refractive Index: 1.508
• CAS DataBase Reference: 1-(4-methylpentan-2-ylidene)-2-phenylhydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methylpentan-2-ylidene)-2-phenylhydrazine(6228-39-3)
• EPA Substance Registry System: 1-(4-methylpentan-2-ylidene)-2-phenylhydrazine(6228-39-3)

Safety Data

• Hazardous Substances Data: 6228-39-3(Hazardous Substances Data)

Usage

General Description

1-(4-methylpentan-2-ylidene)-2-phenylhydrazine is a chemical compound with the molecular formula C15H22N2. It is an organic compound with a hydrazine functional group and a phenyl substituent. 1-(4-methylpentan-2-ylidene)-2-phenylhydrazine is used in the pharmaceutical and chemical industries as a building block for the synthesis of various drugs and other organic compounds. It has potential applications in the development of new pharmaceuticals and materials due to its unique chemical structure and reactivity. However, it is important to handle this compound with care and follow proper safety precautions due to its potential hazards.

Upstream product

• 108-10-1 4-methyl-2-pentanone 
• 100-63-0 phenylhydrazine 

Downstream Products

• 108-10-1 4-methyl-2-pentanone 
• 622-84-4 2-formyl-1-phenylhydrazine 
• 874908-41-5 3-isobutyl-1-phenyl-1H-pyrazole-4-carbaldehyde 
• 66661-67-4 C₁₆H₂₂N₂O₂ 
• 131366-38-6 (1-Isocyanato-1,3-dimethyl-butyl)-phenyl-diazene 
• 31151-19-6 3-isopropyl-2-methyl-1H-indole 
• 3623-86-7 2-isobutyl-1H-indole 
• 66661-60-7 4-Methyl-2-(phenylhydrazono)-pentanal 

Relevant articles and documents

Synthesis and in vitro anti-tumor activity of new oxadiazole thioglycosides

A facile, convenient and high yielding synthesis of novel thioglycosides incorporating 1,3,4-oxadiazole, triazole and or triazine moieties from readily available starting materials has been described. The key step of this protocol is the formation of 3-isobutyl-1-phenyl-1H-pyrazole-4-carbaldehyde (3) via condensation between methyl iso-butyl ketone and phenylhydrazine followed by application of Vilsmeier-Haack reaction. 3 was converted either to 1,3,4-oxadiazole derivative or condensed with O-aminothiols to give the bases 8, 19 and 20 in good yields, respectively. The aglycons 8, 19, and 20 were coupled with different activated halosugars in the presence of basic medium. Pharmacological evaluation of compounds 8, 14, 16 and 22 in vitro against 2-cell lines MCF-7 (breast) and HEPG2 (liver) revealed them to possess high anti-tumor activities with IC50 values ranging from 2.67-20.25 (μg/mL) for breast cell line (MCF-7) and 4.62-43.6 (μg/mL) for liver cell line (HEPG2). None of the tested compounds exhibited any toxicity in doses up to 500 mg kg-1 of the animal body weight.

Electrochemical formation of methoxy- and cyano(phenylazo)alkanes from aldehyde and ketone phenylhydrazones

Several aldehyde and ketone phenylhydrazones were electrooxidized in MeOH. Electrooxidation in the presence of KI or tetraethylammonium p-toluenesulfonate as the supporting electrolyte afforded the corresponding methoxy(phenylazo)alkanes, whereas electrooxidation in the presence of KI, NaCN, and HOAc afforded the cyano(phenylazo)alkanes.