6230-93-9

Basic information

• Product Name: O-METHYL-L-TYROSINE
• Synonyms: L-4-METHOXYPHE;L-TYROSINE-O-METHYL ETHER;H-TYR(ME)-OH;H-PHE(4-OME)-OH;H-P-METHOXY-PHE-OH;H-4-METHOXY-PHE-OH;4-METHOXYPHENYLALANINE;4-METHOXY-PHE-OH
• CAS NO: 6230-93-9
• Molecular Formula: C₈H₁₁O₂PS
• Molecular Weight: 195.22
• EINECS: 228-333-9
• Product Categories: Phenylalanine [Phe, F];Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives
• Mol File: 6230-93-9.mol
• Article Data: 8

Chemical Properties

• Melting Point: 259-261 °C (dec.)(lit.)
• Boiling Point: 93-94℃
• Flash Point: 309.2oC
• Appearance: White to very slightly beige/Powder
• Density: 1.176g/cm3
• Vapor Pressure: 8.66E-14mmHg at 25°C
• Refractive Index: 1.5643 (589.3 nm 20℃)
• PKA: 3.33±0.10(Predicted)
• CAS DataBase Reference: O-METHYL-L-TYROSINE(CAS DataBase Reference)
• NIST Chemistry Reference: O-METHYL-L-TYROSINE(6230-93-9)
• EPA Substance Registry System: O-METHYL-L-TYROSINE(6230-93-9)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 6230-93-9(Hazardous Substances Data)

Usage

General Description

O-Methyl-L-tyrosine is a non-essential amino acid derived from tyrosine. It is a white, crystalline powder that is often used as a precursor in the synthesis of neurotransmitters such as dopamine, norepinephrine, and epinephrine. O-Methyl-L-tyrosine is also known for its ability to inhibit the production of catecholamines, making it a potential candidate for the treatment of conditions related to excessive catecholamine production, such as pheochromocytoma or neurofibromatosis. Additionally, O-Methyl-L-tyrosine has been studied for its potential application in the field of cognitive enhancement and as an alternative treatment for various neurological disorders. However, further research is still needed to fully understand its efficacy and safety in these applications.

InChI:InChI=1/C26H30F2N2O2/c1-2-3-4-17-5-7-19(8-6-17)26(32)30-16-24(31)29-23-14-13-21(28)15-22(23)25(30)18-9-11-20(27)12-10-18/h9-15,17,19,25H,2-8,16H2,1H3,(H,29,31)

Upstream product

• 57557-81-0 O-ethyl S-n-propyl phenylphosphonothioate 
• 71-43-2 benzene 
• 6230-93-9 (-)-O-ethyl-phenyl-thiophosphonic acid 
• 5075-13-8 O-ethyl phenylphosphonochloridothioate 
• 13067-93-1 Cyanofenphos 
• 6231-03-4 diethyl phenylphosphonothioate 
• 6230-64-4 O-Ethyl hydrogen phenylphosphonothioate dicyclohexylammonium salt 
• 172487-18-2 ethyl Phenylphosphinate 

Downstream Products

• 221616-24-6 O,O-diethyl phosphoric O-ethyl phenylphosphonothioic anhydride 
• 4546-19-4 ethyl hydrogen phenylphosphonate 
• 76003-54-8 Dicyclohexyl-amine; compound with phenyl-phosphonothioic acid O-ethyl ester 
• 1351790-99-2 C₁₀H₁₅O₂PS 
• 1351791-00-8 C₁₀H₁₅O₂PS 
• 123278-21-7 S-methyl O-ethyl ohenylphosphonothioate 
• 61733-60-6 (S)-O-ethyl O-methyl phenylphosphonothioate 
• 61733-60-6 (R)-O-ethyl O-methyl phenylphosphonothioate 
• 6230-64-4 (S)-(-)-O-Ethyl hydrogen phenylphosphonothioate dicyclohexylammonium salt 
• 6230-64-4 (R)-(+)-O-Ethyl hydrogen phenylphosphonothioate dicyclohexylammonium salt 
• 13067-93-1 Cyanofenphos 
• 2104-64-5 EPN 
• 70269-57-7 (R)_P(+)-O-ethyl phenylphosphonothioic acid 
• 67964-17-4 (S)_P(-)-O-ethyl phenylphosphonothioic acid 

Relevant articles and documents

Stereochemical inversion of phosphonothioate methanolysis by La(III) and Zn(II): Mechanistic implications for the degradation of organophosphate neurotoxins

The utility of phosphonothioate methanolysis to degrade organophosphate neurotoxins has prompted the stereochemical investigation of this useful transformation. The methanolysis of enantiomerically pure O,S-diethyl phenylphosphonothioate (5) was studied b

Optical resolution reagent and manufacturing method of optically active amines that uses it

PROBLEM TO BE SOLVEDTo provide an effective reagent for optical resolution which produce an optically active amines by resolving the (+/-)-amines and the method for producing the optically active amines characterized by using the same reagent. SOLUTION The O-alkylthiophosphoric acid represented as the following formula (1) is effective for the optical resolution of various amines.

Micellar catalysis of hydroperoxide anion assisted hydrolysis of O-p-cyanophenyl O-ethyl phenylphosphonothionate

The micellar catalyzed reaction between hydroxide or hydroperoxide anion and O-p-cyanophenyl O-ethyl phenylphosponothionate has been examined.Addition of carbonate and borate ions in buffered medium (pH 10) and chloride ion in unbuffered medium has revealed salt effects of three different kinds: (i) increased micellar binding (salting out), (ii) formation of peroxyborate ion, and (iii) counterion effect respectively.The kinetic rate data in hydroxide reaction have been accounted quantitatively in terms of pseudophase ion-exchange model, but this model could be utilized only quantitatively for analysis of reaction with HO2-.