2928-14-5

Basic information

• Product Name: Methyl 3-(4-fluorophenyl)propanoate
• Synonyms: Methyl 3-(4-fluorophenyl)propanoate;Benzenepropanoic acid, 4-fluoro-, Methyl ester
• CAS NO: 2928-14-5
• Molecular Formula: C₁₀H₁₁FO₂
• Molecular Weight: 182.1915432
• Mol File: 2928-14-5.mol
• Article Data: 25

Chemical Properties

• Appearance: /
• Storage Temp.: Room temperature.
• CAS DataBase Reference: Methyl 3-(4-fluorophenyl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-(4-fluorophenyl)propanoate(2928-14-5)
• EPA Substance Registry System: Methyl 3-(4-fluorophenyl)propanoate(2928-14-5)

Safety Data

• Hazardous Substances Data: 2928-14-5(Hazardous Substances Data)

Usage

General Description

Methyl 3-(4-fluorophenyl)propanoate, also known as methyl 4-fluorophenyl-3-acrylate, is an organic compound with the chemical formula C11H11FO2. It is a methyl ester derivative of 4-fluorophenylpropanoic acid, with a molecular weight of 192.2 g/mol. This chemical compound is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is a white to light yellow solid with a faint odor, and it is soluble in organic solvents such as ethanol and methanol. Methyl 3-(4-fluorophenyl)propanoate is flammable and should be handled and stored with appropriate safety measures in place.

Upstream product

• 96426-60-7 methyl (2E)-3-(4-fluorophenyl)-2-propenoate 
• 100891-10-9 methyl p-fluorocinnamate 
• 67-56-1 methanol 
• 405-99-2 para-fluorostyrene 
• 124-38-9 carbon dioxide 
• 459-31-4 3-(4-fluorophenyl)propanoic acid 
• 459-32-5 (E)-4-fluorocinnamic acid 
• 201230-82-2 carbon monoxide 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 186581-53-3 diazomethane 
• 403-41-8 1-(4-Fluorophenyl)ethanol 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 1481-32-9 6-fluoroindan-1-one 
• 63416-70-6 3-(4-fluorophenyl)propanal 
• 5107-21-1 3-(4-fluorophenyl)propanehydrazide 
• 702-15-8 3-(4-fluorophenyl)propan-1-ol 
• 1374135-23-5 methyl 3-[4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]propanoate 
• 1261880-43-6 methyl 3-(4-fluoro-3-iodophenyl)propanoate 
• 623577-33-3 5-(4-fluorophenyl)-1-methyl-1, 2-dihydropyrazol-3-one 
• 777953-39-6 5-(4-fluorophenyl)-2-methyl-1,2-dihydropyrazol-3-one 

Relevant articles and documents

Ligand-controlled cobalt-catalyzed remote hydroboration and alkene isomerization of allylic siloxanes

The Co-catalyzed remote hydroboration and alkene isomerization of allylic siloxanes were realized by a ligand-controlled strategy. The remote hydroboration with dcype provided borylethers, while xantphos favored the formation of silyl enol ethers.

Binuclear Pd(I)-Pd(I) Catalysis Assisted by Iodide Ligands for Selective Hydroformylation of Alkenes and Alkynes

Since its discovery in 1938, hydroformylation has been thoroughly investigated and broadly applied in industry (>107 metric ton yearly). However, the ability to precisely control its regioselectivity with well-established Rh- or Co-catalysts has thus far proven elusive, thereby limiting access to many synthetically valuable aldehydes. Pd-catalysts represent an appealing alternative, yet their use remains sparse due to undesired side-processes. Here, we report a highly selective and exceptionally active catalyst system that is driven by a novel activation strategy and features a unique Pd(I)-Pd(I) mechanism, involving an iodide-assisted binuclear step to release the product. This method enables β-selective hydroformylation of a large range of alkenes and alkynes, including sensitive starting materials. Its utility is demonstrated in the synthesis of antiobesity drug Rimonabant and anti-HIV agent PNU-32945. In a broader context, the new mechanistic understanding enables the development of other carbonylation reactions of high importance to chemical industry.

Synthesis and inhibitory studies of phosphonic acid analogues of homophenylalanine and phenylalanine towards alanyl aminopeptidases

A library of novel phosphonic acid analogues of homophenylalanine and phenylalanine, containing fluorine and bromine atoms in the phenyl ring, have been synthesized. Their inhibitory properties against two important alanine aminopeptidases, of human (hAPN, CD13) and porcine (pAPN) origin, were evaluated. Enzymatic studies and comparison with literature data indicated the higher inhibitory potential of the homophenylalanine over phenylalanine derivatives towards both enzymes. Their inhibition constants were in the submicromolar range for hAPN and the micromolar range for pAPN, with 1-amino-3-(3-fluorophenyl) propylphosphonic acid (compound 15c) being one of the best low-molecular inhibitors of both enzymes. To the best of our knowledge, P1 homophenylalanine analogues are the most active inhibitors of the APN among phosphonic and phosphinic derivatives described in the literature. Therefore, they constitute interesting building blocks for the further design of chemically more complex inhibitors. Based on molecular modeling simulations and SAR (structure-activity relationship) analysis, the optimal architecture of enzyme-inhibitor complexes for hAPN and pAPN were determined.