62497-30-7

Upstream product

• 3172-52-9 2,5-diclorothiophene 
• 100-66-3 methoxybenzene 
• 81665-08-9 2,5-Bis-(4-methoxyphenyl)-1,4-dithia-2,5-dien-1-oxid 
• 158837-25-3 2-chloro-3-(p-methoxyphenyl)thiophene 
• 96-43-5 2-thienyl chloride 
• 37989-51-8 2,5-di(4-methoxyphenyl)-1,4-dithiin 
• 82437-75-0 3-(4-methoxy-phenyl)-thiophene 
• 353269-41-7 4-bromo-2-(4-methoxyphenyl)thiophene 
• 5720-07-0 4-methoxyphenylboronic acid 
• 1220957-72-1 (2Z)-4-bromo-1,3-bis(4-methoxyphenyl)-but-2-en-1-one 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 6303-59-9 (E)-4-(2-bromo-vinyl)-anisole 

Relevant academic research and scientific papers

Sulfurative self-condensation of ketones and elemental sulfur: A three-component access to thiophenes catalyzed by aniline acid-base conjugate pairs

A sulfurative self-condensation method for constructing thiophenes 2 by a reaction between ketones 1 and elemental sulfur is reported. This reaction, which is catalyzed by anilines and their salts with strong acids, starts from readily available and inexp

Synthesis of heterocyclic compounds with adamantane-like cage structures consisting of phosphorus, sulfur, and carbon

The synthesis of novel adamantane-like cage compounds consisting of phosphorus, sulfur, and carbon atoms was developed. We examined the reaction of a variety of acetophenone derivatives with P4S10 in refluxing benzene. A novel noradamantane-like cage compound was also synthesized, when the reaction of 2’-methoxyacetophenone with P4S10 was performed in refluxing toluene. In addition, by using the adamantane-like cage compound, 4,4’-dimethoxybenzophenone and N,N-dimethylbenzamide were successfully transformed into the corresponding thioketone (98%) and benzothioamide (89%), respectively.

Synthesis and properties of Z-1, 3-bis- (aryl)-4-bromo-2-buten-1-ones

Bromination of 1, 3-bis(aryl)-2-buten-1-ones by N-bromosuccinimide in anhydrous carbon tetrachloride gives Z-1, 3-bis(aryl)-4-bromo-2-buten-1-ones. The effect of the nature of substituent in the benzene ring on the course of a reaction with nucleophiles h

Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as potent and selective nonsteroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1)

17β-Estradiol (E2), the most potent female sex hormone, stimulates the growth of mammary tumors and endometriosis via activation of the estrogen receptor α (ERα). 17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1), which is responsible for the catalytic r

The dimerization of 2,5-diaryl-1,4-dithiin radical cations

The electrochemical oxidation of five 2,5-diaryl-1,4-dithiins with aryl = p-anisyl (BAD), p-tolyl (BTD), phenyl (DPD), p-chlorophenyl (BCD) and p-nitrophenyl (BND) has been studied in MeCN-CH2Cl2 (1:1) by cyclic voltammetry (CV), der

Synthesis of unsymmetrical 2,3-diaryl- and 2,4-diarylthiophenes starting from 2,5-dichlorothiophene

Unsymmetrically substituted 2,4-diaryl- and 2,3-diarylthiophenes were synthesized from 2,5-dichlorothiophene via 4-aryl-2-chlorothiophenes in two and four steps including Ni-mediated cross-coupling, respectively. Aluminum chloride-catalyzed reaction of 3-aryl-2-chlorothiophenes with some aromatic ethers unexpectedly led to the formation of the corresponding 2,4-isomers.

Copper(I) Salt Promoted Reactions of Sulfur Nucleophiles with Vinyl Bromides. Simple and Straightforward Preparations of S-Vinyl Thiobenzoates and S,S'-Vinylidene Bisthiobenzoates

Copper(I) salt promoted reaction of vinyl bromides with dibenzoyl disulfide in hot aprotic polar solvent produced thiophene derivatives in moderate yields, while the corresponding reaction with sodium thiobenzoate led to S-vinyl thiobenzoates in good yields.

A New and Simple Route to 3-Arylthiophenes

3-Arylthiophenes were prepared from 2,5-dichlorothiophene in two steps. 2,5-Dichlorothiophene reacted regioselective with various aromatic compounds in the presence of AlCl3 under mild conditions to give 4-aryl-2-chlorothiophenes.The latter compounds were easily converted to the corresponding 3-arylthiophenes by catalytic dechloronation in good yields.

A Novel Friedel-Crafts Type Reaction of 2-Chlorothiophene with Some Active Aromatic Compounds

2-Chlorothiophene (1) was found to easily react with certain active aromatic compounds (2) in the presence of AlCl3 under mild conditions, yielding the corresponding 2-arylthiophenes (3) and 5-chloro-2,2'-bithienyl (5) as the main products.With compounds more reactive than 1, the formation of 3 predominated.Reactions of 1 with aryl alkyl ethers, for example, afforded the corresponding 3 in 44-83percent yields in one step.