62617-91-8Relevant academic research and scientific papers
IMIDAZOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY
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Page/Page column 194; 195, (2014/02/15)
A series of imidazo[l,2-a]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
DIAZENIUMDIOLATE CYCLOHEXYL DERIVATIVES
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Page/Page column 22, (2011/12/04)
A compound having the structure (I) or a pharmaceutically acceptable salt thereof, wherein R3 is hydrogen, deuterium, —OH, —OC1-6alkyl, or halogen; R8 is hydrogen, deuterium, or C1-6alkyl; R11 and R12 are independently hydrogen, —C1-6alkyl, —OH, —OC1-6alkyl, or halogen; R13 and R14 are independently —C1-6alkyl, —(CH2)1-2OH, or —OC1-6alkyl, or, together with the nitrogen atom to which they are attached, form a 4- to 7-membered heterocyclic ring containing one nitrogen atom and 0 or 1 oxygen atoms, wherein said ring is unsubstituted or mono-, di- or tri-substituted with halogen or —C1-6alkyl; R15 is (CR1R2)nC(O)OR16, wherein n is 0, 1 or 2, —C(O)NHCH(R17)OR16, or —C(O)NHCH(R17)C(O)NHCH(R18)C(O)OR16; R16 is hydrogen, C1-6alkyl, or (CH2)1-2N+R19R20R21; R1, R2, R4, R5, R6, R7, R9, R10, R17, R18, R19, R20, and R21 are independently hydrogen or —C1-6alkyl; and stereoisomers thereof, and pharmaceutically acceptable salts thereof, and pharmaceutically acceptable salts of stereoisomers thereof
Catalytic Reaction. 1. Catalytic 1,4-Hydrogenation of α,β-Unsaturated Aldehydes and Ketones using SC-1 Nickel Boride
Belisle, Christopher M.,Young, Yvette M.,Singaram, Bakthan
, p. 5594 - 5598 (2007/10/02)
Ex-situ generated Sc-1 nickelboride (SC-1 Ni2B), prepared by refluxing nickel chloride and sodium borohydride in methanol, is used in the selective 1,4-hydrogenation of α,β-unsaturated ketones and aldehydes at one atmospheric pressure.Previous studies of in-situ generated Ni2B have had the disadvantage of the undesirable side reaction of sodium borohydride with the various functional groups.In contrast, our catalyst cleanly gives the corresponding saturated aldehyde or ketone with no detectable amounts of saturated alcohol.Furthermore, the degree of substitution of the double bond plays a significant role in the rate of hydrogenation.While unsaturated carbonyl compounds containing di- and tri- substituted duoble bonds are readily hydrogenated, tetrasubstituted double bond containing carbonyl compounds are highly unreactive.
SYNTHESIS OF SOME DERIVATIVES OF CYCLOHEXANECARBOXYLIC ACID AND THEIR MESOMORPHOUS CHARACTERISTICS.
Bezborodov, V. S.
, p. 1148 - 1152 (2007/10/02)
The cis- and trans-4-(4-methoxyphenyl)cyclohexane-1-carboxylic, cis-4-(4-methoxyphenyl)-cis-2-methylcyclohexane-1-r-carboxylic, and trans-4-(4-methoxyphenyl)-trans-2-methylcyclohexane-1-r-carboxylic acids and their 4-cyanophenyl esters were obtained.Unlik
