6269-37-0

Usage

InChI:InChI=1/C14H9ClO3/c15-12-7-5-10(6-8-12)13(16)9-1-3-11(4-2-9)14(17)18/h1-8H,(H,17,18)

Upstream product

• 5395-79-9 4'-methyl-4-chlorobenzophenone 
• 122-01-0 4-chloro-benzoyl chloride 
• 74-11-3 para-chlorobenzoic acid 
• 108-88-3 toluene 
• 108-90-7 chlorobenzene 
• 874-60-2 4-methyl-benzoyl chloride 

Downstream Products

• 100623-17-4 4-(4-chloro-α-hydroxy-benzyl)-benzoic acid 
• 30203-91-9 4-(4-chlorobenzyl)benzonitrile 
• 30203-90-8 4-p-Chlorbenzylbenzamid 
• 30203-89-5 4-p-Chlorbenzylbenzoylchlorid 
• 30203-92-0 4-([1,1'-biphenyl]-4-ylmethyl)benzonitrile 
• 179060-79-8 6-[4-(4-chlorobenzoyl)benzoyl]-4,5,6,7-tetrahydrofuro[2,3-c]pyridine 

Relevant academic research and scientific papers

Penicillin inhibitors of purple acid phosphatase

Purple acid phosphatases (PAPs) are binuclear metallohydrolases that have a multitude of biological functions and are found in fungi, bacteria, plants and animals. In mammals, PAP activity is linked with bone resorption and over-expression can lead to bone disorders such as osteoporosis. PAP is therefore an attractive target for the development of drugs to treat this disease. A series of penicillin conjugates, in which 6-aminopenicillanic acid was acylated with aromatic acid chlorides, has been prepared and assayed against pig PAP. The binding mode of most of these conjugates is purely competitive, and some members of this class have potencies comparable to the best PAP inhibitors yet reported. The structurally related penicillin G was shown to be neither an inhibitor nor a substrate for pig PAP. Molecular modelling has been used to examine the binding modes of these compounds in the active site of the enzyme and to rationalise their activities.

Process for the preparation of 1,4-bis(4-fluorobenzoyl)-benzene

Process for producing 1,4-bis-(4-fluorbenzoyl)-benzol by reacting terephthaloyl chloride with fluorbenzol in the presence of aluminium chloride or aluminium bromide, characterized in that aluminium chloride or aluminium bromide is added in metered quantities to a mixture of terephthaloyl chloride and fluorbenzol at temperatures of approximately 25° C. to approximately 68° C. and the mixture is allowed to react at said temperatures.