627-69-0

Basic information

• Product Name: 2-HYDROXYPROPYLACETATE
• Synonyms: Acetic acid 2-hydroxypropyl ester;Nsc35664;Propylene glycol 1-acetate;1-Acetoxy-2-hydroxypropane;1,2-Propanediol 1-acetate;1,2-Propylene glycol 1-monoacetate;1-Acetoxy-2-propanol
• CAS NO: 627-69-0
• Molecular Formula: C₅H₁₀O₃
• Molecular Weight: 118.13
• Mol File: 627-69-0.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 191.006 °C at 760 mmHg
• Flash Point: 77.459 °C
• Appearance: /
• Density: 1.050
• Storage Temp.: Refrigerator, Under inert atmosphere
• Solubility: Chloroform (Slightly), DMSO (Sparingly), Methanol (Slightly)
• PKA: 14.22±0.20(Predicted)
• CAS DataBase Reference: 2-HYDROXYPROPYLACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXYPROPYLACETATE(627-69-0)
• EPA Substance Registry System: 2-HYDROXYPROPYLACETATE(627-69-0)

Safety Data

• Hazardous Substances Data: 627-69-0(Hazardous Substances Data)

Usage

Uses

1,2-Propanediol-1-Acetate, is a building block used in various chemical synthesis.

InChI:InChI=1S/C5H10O3/c1-4(6)3-8-5(2)7/h4,6H,3H2,1-2H3

Upstream product

• 127-08-2 potassium acetate 
• 127-00-4 1-Chloro-2-propanol 
• 64-19-7 acetic acid 
• 75-56-9 methyloxirane 
• 3390-12-3 2,4-dimethyl-1,3-dioxolane 
• 187737-37-7 propene 
• 57-55-6 propylene glycol 
• 108-24-7 acetic anhydride 
• 64-17-5 ethanol 
• 592-20-1 Acetol acetate 
• 56-23-5 tetrachloromethane 
• 591-87-7 Allyl acetate 
• 65055-45-0 2-Methoxy-2,4-dimethyl-[1,3,2]dioxasilolane 
• 10602-14-9 β-hydroxypropyl phosphate 

Downstream Products

• 623-84-7 1,2-diacetoxypropane 
• 64-19-7 acetic acid 
• 7713-44-2 5-methyl-oxazolidine-2,4-dione 2-[(1-phenyl-ethylidene)-hydrazone] 

Relevant articles and documents

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COMPOUNDS AND COMPOSITIONS FOR OCULAR DELIVERY

The present invention provides new prodrags of Sunitinib, Brinzolamide, and Dorzolamide and compositions to treat medical disorders, for example glaucoma, a disorder or abnormality related to an increase in intraocular pressure (TOP), a disorder requiring neuroprotection, age-related macular degeneration, or diabetic retinopathy.

Diisopropylethylamine-triggered, highly efficient, self-catalyzed regioselective acylation of carbohydrates and diols

A diisopropylethylamine (DIPEA)-triggered, self-catalyzed, regioselective acylation of carbohydrates and diols is presented. The hydroxyl groups can be acylated by the corresponding anhydride in MeCN in the presence of a catalytic amount of DIPEA. This method is comparatively green and mild as it uses less organic base compared with other selective acylation methods. Mechanistic studies indicate that DIPEA reacts with the anhydride to form a carboxylate ion, and then the carboxylate ion could catalyze the selective acylation through a dual H-bonding interaction.