6283-47-2

Basic information

• Product Name: ethyl hydroxy[4-(propan-2-yl)phenyl]acetate
• CAS NO: 6283-47-2
• Molecular Formula: C₁₃H₁₈O₃
• Molecular Weight: 222.2802
• Mol File: 6283-47-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 322.4°C at 760 mmHg
• Flash Point: 129.4°C
• Density: 1.073g/cm³
• Vapor Pressure: 0.000115mmHg at 25°C
• Refractive Index: 1.516
• CAS DataBase Reference: ethyl hydroxy[4-(propan-2-yl)phenyl]acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl hydroxy[4-(propan-2-yl)phenyl]acetate(6283-47-2)
• EPA Substance Registry System: ethyl hydroxy[4-(propan-2-yl)phenyl]acetate(6283-47-2)

Safety Data

• Hazardous Substances Data: 6283-47-2(Hazardous Substances Data)

Upstream product

• 924-44-7 glyoxylic acid ethyl ester 
• 98-82-8 Isopropylbenzene 
• 34906-84-8 ethyl 2-(4-isopropylphenyl)-2-oxoacetate 

Downstream Products

• 77053-73-7 (1S,2R)-1-(4-Isopropyl-phenyl)-cyclopropane-1,2-dicarboxylic acid diethyl ester 
• 77053-84-0 (1R,2S)-1-(4-Isopropyl-phenyl)-cyclopropane-1,2-dicarboxylic acid 
• 77053-89-5 1-(p-Cumyl)-1,2-cyclopropan-dicarboximid 
• 86215-47-6 1-(p-Cumyl)-3-azabicyclo<3.1.0>hexan 
• 128839-61-2 Fluoro-(4-isopropyl-phenyl)-acetic acid ethyl ester 
• 77053-59-9 Brom-(4-isopropyl-phenyl)-essigsaeure-ethylester 
• 32957-08-7 2-amino-5-(4-isopropyl-phenyl)-oxazol-4-one 

Relevant articles and documents

Simple and efficient synthesis of racemic substituted mandelic acid esters from nonactivated arenes and ethyl glyoxylate

Direct synthesis of racemic aromatic α-hydroxyacetic acid esters via Friedel-Crafts reaction of nonactivated, simple arenes with ethyl glyoxylate promoted by SnCl4 or AlCl3 is described. The use of SnCl4 opens a fast access to various alkyl- and aryl-substituted mandelic acids esters at room temperature within two hours in good yield (>80%) and with high regioselectivity. The procedure was successfully employed also for the alkylation of compounds with condensed aromatic rings. Alternative hydroxyalkylations with AlCl3 require longer reaction time and higher temperature to get a good yield.