6288-14-8

Basic information

• Product Name: 1-oxo-1-(phenylamino)propan-2-yl acetate
• Synonyms: 1-Anilino-1-oxo-2-propanyl acetate
• CAS NO: 6288-14-8
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.2258
• Mol File: 6288-14-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 377.3°C at 760 mmHg
• Flash Point: 182°C
• Density: 1.178g/cm³
• Vapor Pressure: 6.82E-06mmHg at 25°C
• Refractive Index: 1.551
• CAS DataBase Reference: 1-oxo-1-(phenylamino)propan-2-yl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-oxo-1-(phenylamino)propan-2-yl acetate(6288-14-8)
• EPA Substance Registry System: 1-oxo-1-(phenylamino)propan-2-yl acetate(6288-14-8)

Safety Data

• Hazardous Substances Data: 6288-14-8(Hazardous Substances Data)

Usage

Chemical class

Acetate esters

Derivative

Acetic acid

Common uses

Synthesis of pharmaceutical drugs, building block in organic chemistry

Potential use

Pharmaceutical research and drug development

Also known as

2-acetoxy-1-phenylethan-1-one

Applications

Production of flavors and fragrances, manufacturing of plastics and polymers

Versatility

Diverse industrial and scientific uses

Upstream product

• 38939-83-2 2-acetoxypropionyl chloride 
• 62-53-3 aniline 
• 36394-75-9 (S)-2-acetoxypropanoyl chloride 
• 1003855-72-8 (S)-2-(toluene-sulfonyl-⁽⁴⁾-oxy)-propionic acid anilide 
• 127-08-2 potassium acetate 
• 64-17-5 ethanol 
• 535-17-1 (S)-2-acetoxypropionic acid 
• 103-71-9 phenyl isocyanate 
• 535-17-1 2-acetoxypropionic acid 
• 21262-52-2 2-chloro-N-phenylpropanamide 
• 127-09-3 sodium acetate 

Downstream Products

• 106942-22-7 lactanilide 
• 64-19-7 acetic acid 

Relevant articles and documents

Design, synthesis, and evaluation of novel inhibitors for wild-type human serine racemase

Most of the endogenous free D-serine (about 90%) in the brain is produced by serine racemase (SR). D-Serine in the brain is involved in neurodegenerative disorders and epileptic states as an endogenous co-agonist of the NMDA-type glutamate receptor. Thus, SR inhibitors are expected to be novel therapeutic candidates for the treatment of these disorders. In this study, we solved the crystal structure of wild-type SR, and tried to identify a new inhibitor of SR by in silico screening using the structural information. As a result, we identified two hit compounds by their in vitro evaluations using wild-type SR. Based on the structure of the more potent hit compound 1, we synthesized 15 derivatives and evaluated their inhibitory activities against wild-type SR. Among them, the compound 9C showed relatively high inhibitory potency for wild-type SR. Compound 9C was a more potent inhibitor than compound 24, which was synthesized by our group based upon the structural information of the mutant-type SR.

Preparation and use of (S)-O-acetyllactyl chloride (Mosandl's reagent) as a chiral derivatizing agent

(S)-O-Acetyllactyl chloride is used as a versatile chiral derivatizing agent for the chromatographic determination of the enantiomeric excesses of alcohols or amines. However, some precautions must be taken to avoid its racemization during preparation and use. In addition, the racemic counterpart of this reagent can be used to determine the best analytical separation conditions.