6290-08-0

Basic information

• Product Name: 1-(3-bromobenzyl)-3-(4-ethoxyphenyl)-1-(tetrahydrofuran-2-ylmethyl)thiourea
• CAS NO: 6290-08-0
• Molecular Formula: C₁₃H₁₈O₃
• Molecular Weight: 449.4044
• Mol File: 6290-08-0.mol

Chemical Properties

• Boiling Point: 553.7°C at 760 mmHg
• Flash Point: 288.7°C
• Density: 1.372g/cm³
• Vapor Pressure: 2.65E-12mmHg at 25°C
• Refractive Index: 1.638
• CAS DataBase Reference: 1-(3-bromobenzyl)-3-(4-ethoxyphenyl)-1-(tetrahydrofuran-2-ylmethyl)thiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-bromobenzyl)-3-(4-ethoxyphenyl)-1-(tetrahydrofuran-2-ylmethyl)thiourea(6290-08-0)
• EPA Substance Registry System: 1-(3-bromobenzyl)-3-(4-ethoxyphenyl)-1-(tetrahydrofuran-2-ylmethyl)thiourea(6290-08-0)

Safety Data

• Hazardous Substances Data: 6290-08-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-(3-bromobenzyl)-3-(4-ethoxyphenyl)-1-(tetrahydrofuran-2-ylmethyl)thiourea is used as a potential therapeutic agent for various medical conditions due to its diverse biological activities, including antiviral, antimicrobial, and antitumor properties. The presence of the bromobenzyl and ethoxyphenyl groups, along with the tetrahydrofuran-2-ylmethyl group, indicates that this compound may have significant pharmacological potential.
Used in Medicinal Chemistry Research:
1-(3-bromobenzyl)-3-(4-ethoxyphenyl)-1-(tetrahydrofuran-2-ylmethyl)thiourea is used as a subject of study in medicinal chemistry to explore its biological activities and potential applications. Further research is needed to fully understand its interactions with biological systems and to determine its specific uses in the development of new drugs or therapies.
Used in Drug Design and Development:
1-(3-bromobenzyl)-3-(4-ethoxyphenyl)-1-(tetrahydrofuran-2-ylmethyl)thiourea may be utilized in the design and development of new drugs, particularly those targeting viral, bacterial, or cancer-related conditions. Its unique structural features could provide a foundation for the creation of novel therapeutic agents with improved efficacy and selectivity.

Upstream product

• 103-82-2 phenylacetic acid 
• 599-67-7 1,1-diphenylethanol 
• 60-12-8 2-phenylethanol 
• 555-16-8 4-nitrobenzaldehdye 
• 123-11-5 4-methoxy-benzaldehyde 
• 104-94-9 4-methoxy-aniline 
• 126-30-7 2,2-Dimethyl-1,3-propanediol 
• 65849-85-6 3,3,9,9-Tetramethyl-1,5,7,11-tetraoxaspiro<5.5>undecan 
• 105-13-5 4-Methoxybenzyl alcohol 

Downstream Products

• 123-11-5 4-methoxy-benzaldehyde 
• 6712-20-5 2-(4-methoxyphenyl)-[1,3]dithiolane 
• 83726-14-1 4-(5,5-Dimethyl-[1,3]dioxan-2-yl)-cyclohex-3-enone 
• 83726-08-3 2-(4-Methoxy-cyclohexa-1,4-dienyl)-5,5-dimethyl-[1,3]dioxane 

Relevant articles and documents

New Br?nsted-Lewis acidic quaternary ammonium ionic liquids: Synthesis, acidity determination and acidity-catalytic activity relationship

A series of new Br?nsted-Lewis acidic ionic liquids, which are operational simplicity, high stability, low cost and applicable for scaling up, have been synthesized and their activity for acetalization was examined. The comprehensive studies on the acidity-catalytic performance relationship of the Br?nsted-Lewis acidic ionic liquids were performed. IR spectroscopy results confirmed that the new Br?nsted-Lewis acidic ionic liquids possess both Br?nsted and Lewis acid sites. The acidities were determined by Hammett method, and further studies on acidity-activity relationship revealed that the acidity played a key role in the acid-catalyzed probe reactions.

Four acid-catalysed dehydration reactions proceed without interference

Four acid-catalysed dehydration reactions can proceed in one pot, simultaneously and without interference, to yield one imine, one acetal (or boronic ester), one ester and one alkene, even though many other cross-products could be conceived. This advanced

Facile aldolization catalyzed by ionic liquid [4-sulfbmpyrazine][BF 4]

The acidic functionalized ionic liquid 1-(4-sulfonic group)butyl-3- methylpyrazine tetrafluoroborate (abbreviated as [4-sulfbmpyrazine][BF 4]) was employed as the catalyst of the condensation of aromatic aldehyde and diols. The optimized condition was as follows: aromatic aldehyde (0.20 mol), diols (0.30 mol) and [4-sulfbmpyrazine][BF4] (0.60 g) were refluxed in cyclohexane (10.00 mL) for 1 h. A series of aromatic aldehydes were studied and afforded the corresponding acetals products with good yields which were from 70.3 to 96.9 %. The ionic liquid catalyst could be recycled for four times without significant loss of catalyst reactivity.

Synthesis of novel solid acidic ionic liquid polymer and its catalytic activities

The novel solid acidic ionic liquid polymer has been synthesized through the copolymerization of acidic ionic liquid oligomers and resorcinol- formaldehyde (RF resin). The catalytic activities were investigated through the acetalization. The results showed that the PIL was very efficient for the reactions with the average yield over 99.0%. The procedure was quite simple with just one-step to complete both the reactions. The high hydrophobic BET surface, high catalytic activities and high stability gave the PIL great potential for green chemical processes. Pleiades Publishing, Ltd., 2013.

Indium(III) triflate catalysed transacetalisation reactions of diols and triols under solvent-free conditions

Acyclic acetals and ketals undergo transacetalisation in the presence of catalytic quantities of indium(III) triflate (In(OTf)3) and diols or triols under solvent-free conditions to generate the corresponding cyclic acetals and ketals in excellent yield. The methodology has been further developed to encompass a tandem acetalisation-acetal exchange protocol, which provides a facile and high yielding route to cyclic ketals from unreactive ketones under very mild reaction conditions.

Synthesis of a novel ionic liquid with both Lewis and Br?nsted acid sites and its catalytic activities

The novel ionic liquid with both Lewis and Br?nsted acid sites has been synthesized and its catalytic activities for acetalization and Michael addition were investigated carefully. The novel ionic liquid was stable to water and could be used in aqueous solution. Furthermore, the molar ratio of the Lewis and Br?nsted acid sites could be adjusted according to different reactions. The results showed that the novel ionic liquid was very efficient for the traditional acid-catalyzed reactions with good to excellent yields in short time.

Bismuth compounds in organic synthesis: Synthesis of dioxanes, dioxepines, and dioxolanes catalyzed by bismuth(III) triflate

A simple method for the synthesis of 1,3-dioxolanes from carbonyl compounds has been developed using 1,2-bis(trimethylsilyloxy)ethane in the presence of bismuth(III) triflate as a catalyst. The bismuth(III) triflate catalyzed synthesis of a range of dioxanes and dioxepines has also been developed. In these latter cases, the carbonyl compound is treated with a diol, and triethyl orthoformate is used as a water scavenger. All these methods avoid the use of a Dean-Stark trap. Georg Thieme Verlag Stuttgart.

3,3,9,9-Tetramethyl-1,5,7,11-tetraoxaspiro[5.5]undecane as a reagent for protection of carbonyl compounds

3,3,9,9-Tetramethyl-1,5,7,11-tetraoxaspiro[5.5]undecane is introduced as a new, stable and chemoselective reagent for the protection of aldehydes and ketones under mild reaction condition in high yield.

Sequential and tandem oxidation/acetalization procedures for the direct generation of acetals from alcohols

Alcohols are transformed directly into either acyclic or cyclic acetals in both tandem and sequential oxidation/acetalization processes using manganese dioxide, trialkyl orthoformates and catalytic quantities of indium triflate.

Solid supported reactions and reagents XIV [1]: Envirocat EPZG as a novel catalyst for selective acetalization of aldehydes and ketones

Envirocat EPZG is an efficient reusable catalyst for acetalization of aldehydes and ketones. The isolation of pure products in high yields by simple filtration and evaporation of the solvent is an important feature of this method.