54208-72-9

Basic information

• Product Name: Salbutamol Acetonide
• Synonyms: Salbutamol Acetonide
• CAS NO: 54208-72-9
• Molecular Formula: C₁₆H₂₅NO₃
• Molecular Weight: 279.3746
• Mol File: 54208-72-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Salbutamol Acetonide(CAS DataBase Reference)
• NIST Chemistry Reference: Salbutamol Acetonide(54208-72-9)
• EPA Substance Registry System: Salbutamol Acetonide(54208-72-9)

Safety Data

• Hazardous Substances Data: 54208-72-9(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Salbutamol Acetonide is a Salbutamol (A514500) derivative. It has higher lipophilicity than Salbutamol, which allows an increase of the incorporation efficiency into solid lipid microparticles (SLMs) drug carrier system.

Upstream product

• 18559-94-9 Salbutamol 
• 67-64-1 acetone 
• 62932-94-9 2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone 
• 90-02-8 salicylaldehyde 
• 115787-50-3 5-(2-bromoacetyl)-2-hydroxybenzaldehyde 
• 102293-80-1 2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone 
• 77-76-9 2,2-dimethoxy-propane 
• 54030-34-1 1-(2,2-dimethyl-4H-benzo[d][1,3]dioxan-6-yl)ethanone 
• 39235-58-0 4-hydroxy-3-hydroxymethylacetophenone 
• 75-64-9 tert-butylamine 
• 238762-31-7 (R)-2-(N-tert-butylamino)-1-(2,2-dimethyl-4H-benzo[3,4-e]1,3-dioxin-6-yl)ethanol 

Downstream Products

• 238762-33-9 C₁₆H₂₅NO₃*C₂₀H₁₈O₈ 
• 50293-91-9 (+/-)-salbutamol hydrochloride 
• 18559-94-9 Salbutamol 
• 238762-33-9 C₁₆H₂₅NO₃*C₂₀H₁₈O₈ 
• 238762-33-9 2C₁₆H₂₅NO₃*C₂₀H₁₈O₈ 

Relevant articles and documents

Salbutamol hydrochloride preparation method suitable for industrial production

The invention discloses a salbutamol hydrochloride preparation method suitable for industrial production. 4-hydroxy-3-hydroxymethylacetophenone used as an initial raw material undergoes epoxy protection, oxidation, reductive amination and deprotection salification to obtain salbutamol hydrochloride. The method has the advantages of no bromination process in the whole reaction process, avoidance ofuse of high-risk reagents, small environmental pollution, low device requirements, simplicity in operation, mild reaction conditions, simplified steps, low production cost, and suitability for industrial production.

Levalbuterol intermediate and synthetic method of levalbuterol hydrochloride

The invention provides a levalbuterol intermediate and a levalbuterol hydrochloride synthesis method, and relates to a levalbuterol intermediate and a method for preparing levalbuterol hydrochloride from the intermediate. The method comprises steps as follows: 2-halogenate-1-(2,2-dimelthyl-4-hydrogen-benzo [d][1,3] dioxane)-butanone and organic amine have a Hoffman alkylation reaction to prepare a compound in the formula 2, the structural formula of the compound is shown in the specification, and the compound in the formula 2 is subjected to a reduction reaction, optically pure organic acid resolution and deprotection by hydrochloric acid to obtain levalbuterol hydrochloride. The method does not need processes of protection or deprotection and the like of hydroxyl groups on a benzene ring, protection, deprotection and purification processes are reduced, the synthesis route is short, operation is simple, meanwhile, borane-thioether does not need to be used as a reduction agent, and safety and environmental protection are realized.

Process for the production of optically enriched (R)- or (S)-albuterol

A process for the production of optically enriched (R)- or (S)-albuterol or (R)- or (S)-albuterol salts by the resolution of a novel ketal derivative 2-(N-t-butylamino)-1-(+2,2-dimethyl-1,2-benzodioxin-6-yl) ethanol, with a chiral tartaric acid derivative.