63002-71-1

Upstream product

• 75541-86-5 2-(4-nitrobenzoylamino)benzoic acid methyl ester 
• 134-20-3 2-carbomethoxyaniline 
• 122-04-3 4-nitro-benzoyl chloride 
• 118-92-3 anthranilic acid 
• 88184-98-9 4-Nitro-benzoic acid N'-(2-amino-benzoyl)-hydrazide 
• 16063-05-1 2-(4-nitrophenyl)-4H-3,1-benzoxazin-4-one 
• 118-48-9 isatoic anhydride 
• 636-97-5 N-amino-(4-nitrophenyl)carboxamide 
• 51098-36-3 2-(4-nitrobenzoylamino)benzoylhydrazine 

Downstream Products

• 6761-26-8 N-(2-(4-nitrophenyl)-4-oxoquinazolin-3(4H)-yl)benzamide 
• 1414886-89-7 2-(4-nitrophenyl)-3-{[(3-(pyridin-4-yl)-1-(p-tolyl)-1H-pyrazol-4-yl)methylene]amino}quinazolin-4(3H)-one 

Relevant academic research and scientific papers

Asymmetric Synthesis of N-N Axially Chiral Compounds by Phase-Transfer-Catalyzed Alkylations

N-N axially chiral skeletons are significant structural motifs in natural products, pharmaceuticals, and functional materials. Herein we disclose a method for the asymmetric synthesis of N-N axially chiral compounds by phase-transfer catalysis. A wide range of N-N axially chiral quinazolinone derivatives were prepared in high yields with excellent stereoselectivities. Furthermore, the synthetic utility of the protocol was proved by large-scale reaction and transformation of the product. Density functional theory calculations provide insight into the mechanism.

Quinazolinone-schiff's base hybrids as phosphodiesterase 4b inhibitors with dual activity against COPD and lung cancer

A series of thirty compounds of quinazolinone-Schiff's base hybrids were rationally designed, synthesized, and evaluated for their in vitro Phosphodiesterase 4B inhibition, anti-lung and anti-colon cancer activities. Compounds 9, 16, 23, 29, 30, 31, 32 an

Synthesis and biological evaluation of certain 3-substituted benzylideneamino-2-(4-nitrophenyl)quinazolin-4(3H)-one derivatives

Certain new 3H-quinazolin-4-one Schiff's bases were synthesized and screened for their activities against ulcerative colitis "UC". Their activity against phospholipase A2 and protease enzymes was also investigated. Some compounds possessed remarkable effe

Synthesis and characterization of quinazoline derivatives: Search for hybrid molecule as diuretic and antihypertensive agents

To explore the pharmacological and structure-activity relationship of a series of N-substituted-(4-oxo-2-substituted-phenylquinazolin-3-(4H)-yl), substituted benzene sulfonamide derivatives (1-25) were synthesized from substituted anthranilic acids derive

Identification of novel quinazolin-4(3H)-ones as inhibitors of thermolysin, the prototype of the M4 family of proteinases

A combinatorial series of novel quinazolin-4(3H)-ones were synthesised and their structures were established based on spectroscopic data (IR, NMR, EI-MS, and FAB-MS). The compounds were tested for inhibition of the zinc metalloproteinase thermolysin (TLN) utilizing a chemical array-based approach. Some of the compounds were found to inhibit TLN, with IC50 values ranging from 0.0115 μM (compound 3) to 122,637 μM (compound 29). Compound 3 [3-phenyl-2-(trifluoromethyl) quinazolin-4(3H)-one] (IC50 = 0.0115 μM) and compound 35 [3-(isopropylideneamino)-2,2-dimethyl-2,3-dihydroquinazolin-4 (1H)-one] (IC50 = 0.2477 μM) were found to be the most potent inhibitors.

Synthesis of some new benzoxazine derivatives of biological interest

The synthesis of a number of biologically important imino-quinazolones has been achieved by the condensation of 3-amino-2-aryl-4-quinazolone and aromatic aldehydes.

A New Synthesis of 2-Aryl-3,4-dihydro-5H-1,3,4-benzotriazepin-5-ones

The reaction of 2-aryl-3,1-benzoxazine-4-ones (1) and hydrazine hydrate in refluxing xylene yields 2-aryl-3,4-dihydro-5H-1,3,4-benzotriazepin-5-ones in 55-74percent yield.In basic conditions this reaction, however, gives 2-aryl-3-aminoquinazolin-4(3H)-one

FORMATION OF AMINOQUINAZOLINONES FROM N-(2-AMINOBENZOYL)-N'-AROYLHYDRAZINES

The ring closure of N-(2-aminobenzoyl)-N'-aroylhydrazines 3 in AcOH/TsOH yielded 2-aryl-3-amino-4(3H)-quinazolinones 6 instead of 2-aryl-3,4-dihydro-5H-1,3,4-benzotriazepin-5-ones 4 as reported before.The structure of the aminoquinazolinones 6 was confirm