63164-16-9

Usage

Uses

Used in Organic Synthesis:
2,4-Dibromobutyric acid is utilized as a key intermediate in organic synthesis for the production of a wide range of organic compounds. Its unique structure with bromine atoms allows for versatile chemical reactions, making it a valuable component in the synthesis process.
Used in Chemical Reactions as a Reagent:
As a reagent, 2,4-Dibromobutyric acid is employed in various chemical reactions to facilitate or enhance the process. Its presence can influence the outcome of these reactions, providing a means to achieve desired products with specific properties.
Used in Pharmaceutical Manufacturing:
In the pharmaceutical industry, 2,4-Dibromobutyric acid is used as a building block for the synthesis of pharmaceuticals. Its contribution to the development of new drugs is significant, as it can be incorporated into the molecular structures of potential medications.
Used in Agrochemical Production:
2,4-Dibromobutyric acid also finds application in the agrochemical sector, where it is used in the synthesis of compounds for agricultural purposes. This includes the development of pesticides, herbicides, and other chemicals that aid in crop protection and enhancement.
Used as a Research Chemical in Laboratories:
In academic and research settings, 2,4-Dibromobutyric acid serves as an important research chemical. It is used to study organic reactions and chemical properties, contributing to the advancement of knowledge in the field of organic chemistry.

InChI:InChI=1/C4H6Br2O2/c5-2-1-3(6)4(7)8/h3H,1-2H2,(H,7,8)

Upstream product

• 96-48-0 4-butanolide 
• 1489-69-6 Cyclopropanecarboxaldehyde 
• 75-15-0 carbon disulfide 
• 7726-95-6 bromine 
• 7789-60-8 phosphorus tribromide 
• 1759-53-1 cyclopropanecarboxylic acid 
• 52412-07-4 2,4-dibromo-butyryl bromide 

Downstream Products

• 36847-51-5 ethyl 2,4-dibromobutyrate 
• 93189-96-9 α-cyclohexylamino-γ-hydroxybutyric acid cyclohexylamide 
• 101785-30-2 α-Benzylamino-γ-hydroxy-N-benzyl-butyramid 
• 77629-96-0 2,4-dibromobutyric acid tert-butyl ester 
• 5061-21-2 α-bromo-γ-butyrolactone 
• 93019-32-0 4-Hydroxy-2-anilino-buttersaeureanilid 
• 82820-87-9 2,4-dibromobutanoyl chloride 

Relevant academic research and scientific papers

A two-phase bromination process using tetraalkylammonium hydroxide for the practical synthesis of α-bromolactones from lactones

A simple and efficient method for α-brominating lactones that affords α-bromolactones under mild conditions using tetraalkylammonium hydroxide (R4N) as a base was developed. Lactones are ring-opened with Br2 and a substoichiometric amount of PBr3, leading to good yields of the corresponding α-bromocarboxylic acids. Subsequent intramolecular cyclization over 1 h using a two-phase system (H2O/CHCl3) containing R4N afforded α-bromo lactones in good yields. This method can be applied at the 10 mmol scale using simple operations. α-Bromo-δ-valerolactone, which is extremely reactive and difficult to isolate, could be isolated and stored in a freezer for about one week using the developed method. Optimizing the solvent for environmentally friendly large-scale syntheses revealed that methyl ethyl ketone (MEK) was as effective. In addition, in situ-generated α-bromo-δ-valerolactone was directly converted into a sulfur-substituted functional lactone without difficulty by reacting it with a sulfur nucleophile in one pot without isolation. This new bromination system is expected to facilitate the industrial use of α-bromolactones as important intermediates.

Peptide deformylase inhibitors

The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhibition of bacterial peptide deformylase (PDF) activity.

PEPTIDE DEFORMYLASE INHIBITORS

The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhi-bition of bacterial peptide deformylase (PDF) activity

Convenient Syntheses of Cyclic Carboxamides from α,β,γ,δ and ε-halocarboxamides under Phase Transfer Conditions

Piperazine-2,5-diones (2) were prepared by N-alkylation between two molecules of α-halocarboxamides (1) in the presence of a phase transfer catalyst in yields of 64-88percent. β,γ,δ and ε-Lactams (6,9 and 13) were similarly synthesized by intramolecular N-alkylation of the corresponding halocarboxamides (5, 8 and 12) under phase transfer conditions in 53-99percent yields.Keywords--piperazine-2,5-dione; β-lactam; γ, δ, and ε lactams; bis-β-lactam; phase transfer catalyst; intramolecular N-alkylation