6342-90-1

Usage

Uses

Used in Pharmaceutical Industry:
4-(6-methoxynaphthalen-2-yl)-4-oxobutanoic acid is used as a chemical intermediate for drug development and research. Its unique structural features, including the naphthalene ring and the methoxy and butanoyl groups, may provide opportunities for the synthesis of new pharmaceutical compounds with potential therapeutic applications.
Used in Drug Synthesis:
4-(6-methoxynaphthalen-2-yl)-4-oxobutanoic acid is used as a building block in the synthesis of various pharmaceutical compounds. Its aromatic carboxylic acid nature and the presence of the naphthalene ring and functional groups make it a valuable component in the creation of novel drug molecules with potential therapeutic effects.
Used in Medicinal Chemistry Research:
4-(6-methoxynaphthalen-2-yl)-4-oxobutanoic acid is used as a research tool in medicinal chemistry to explore its potential as a lead compound or to understand its interactions with biological targets. Its structural features may offer insights into the design of new drugs with improved efficacy and selectivity.

Upstream product

• 108-30-5 succinic acid anhydride 
• 93-04-9 2-Methoxynaphthalene 
• 922-84-9 ethane-1,1,2-tricarboxylic acid 
• 58601-32-4 6-methoxy-2-naphthoyl chloride 
• 37992-38-4 acido β-(6-metossi-2-naftoil)acrilico 
• 7446-70-0 aluminium trichloride 
• 98-95-3 nitrobenzene 
• 5111-65-9 2-Bromo-6-methoxynaphthalene 
• 15231-91-1 6-bromo-naphthalen-2-ol 
• 3900-45-6 6-methoxy-2-acetylnaphthalene 

Downstream Products

• 7148-10-9 4-<6-Methoxy-2-naphthyl>-4-oxo-buttersaeure-methylester 
• 7495-48-9 ethyl 4-(6-methoxynaphthalen-2-yl)-4-oxobutanoate 

Relevant academic research and scientific papers

Synthesis of functionalized molecular motors

Synthetic routes to two molecular motors are reported. The sterically hindered central olefinic bond connecting the two halves of these C 2-symmetric molecules was prepared by a McMurry reaction. In this way, a motor with two five-membered rings and a motor with two six-membered rings were prepared, both with two versatile methoxy substituents at positions not interfering with the rotary behavior. Georg Thieme Verlag Stuttgart.

Syntheses and antiinflammatory activity of some 6-aryl-2,3,4,5-tetrahydro-3-pyridazinones

6-Aryl-2, 3, 4, 5-tetrahydro-3-pyridazinones (2c-22c) are obtained by dehydrocyclisation of various hydrazides formed by the reaction of appropriate methyl β-aroylpropionate and hydrazine hydrate in the presence of anhydrous sodium acetate. They show promising antiinflammatory activity during their evaluation by carrageenin induced paw edema test in rats.

Novel 6-oxo-6-naphthylhexanoic acid derivatives with anti-inflammatory and 5-lipoxygenase inhibitory activity

A series of novel 6-(6-alkoxy-2-naphthyl)oxoalkanoates and alkanamides were synthesized as inhibitors of inflammation and 5-lipoxygenase.They were evaluated in vivo for anti-inflammatory activity in the established adjuvent arthritis assay in rats and in vitro as inhibitors of 5-lipoxygenase in rat basophilic leukemia (RBL) cells.N-Hydroxy-N-methyl-6-(6-methoxy-2-naphthyl)-6-oxohexanamide, compound 28, which is representative of the more potent anti-inflammatory / 5-lipogenase inhibitors in the series was approximately twice as potent as the standard, ibuprofen in the adjuvent rat and exhibited an IC50 of 0.25 micromolar in the RBL assay.

A Convenient Synthesis of Ethyl/Methyl 4-(6-Methoxy-1-oxo-1,2,3,4-tetrahydro-2-naphthylidene)butanoate

A novel, efficient synthesis of the title enone-ester 1, a promising, versatile intermediate for a variety of tri- and tetra-cyclic products, particularly the 19-norsteroids, is described.