63599-02-0

Basic information

• Product Name: (+)-1-nitro-2-propanol
• CAS NO: 63599-02-0
• Molecular Weight: 105.093
• Mol File: 63599-02-0.mol

Chemical Properties

• CAS DataBase Reference: (+)-1-nitro-2-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-1-nitro-2-propanol(63599-02-0)
• EPA Substance Registry System: (+)-1-nitro-2-propanol(63599-02-0)

Safety Data

• Hazardous Substances Data: 63599-02-0(Hazardous Substances Data)

Upstream product

• 3156-73-8 2-hydroxy-1-nitropropane 
• 108-30-5 succinic acid anhydride 
• 75-52-5 nitromethane 
• 75-07-0 acetaldehyde 
• 108-05-4 vinyl acetate 

Downstream Products

• 144380-73-4 ((R)-1-Methyl-2-nitro-ethoxymethyl)-benzene 
• 3156-76-1 (-)-1-nitro-2-acetoxypropane 

Relevant articles and documents

Lipase catalysed resolution of nitro aldol adducts

The kinetic resolution of a range of 1-nitro-2-alkanols by lipase-catalysed esterification using various lipases and succinic anhydride as an acyl donor has been studied. E values of up to 100 were obtained with Novozym 435 in the resolution of 1-nitro-2-pentanol with succinic anhydride in TBME. Acylation with succinic anhydride proved much more enantioselective than with vinyl acetate.

A Practical, Component-Based Synthetic Route to Methylthiolincosamine Permitting Facile Northern-Half Diversification of Lincosamide Antibiotics

The development of a flexible, component-based synthetic route to the amino sugar fragment of the lincosamide antibiotics is described. This route hinges on the application and extension of nitroaldol chemistry to forge strategic bonds within complex amino sugar targets and employs a glycal epoxide as a versatile glycosyl donor for the installation of anomeric groups. Through building-block exchange and late-stage functionalization, this route affords access to a host of rationally designed lincosamides otherwise inaccessible by semisynthesis and underpins a platform for the discovery of new lincosamide antibiotics.

LINCONSAMIDE ANTIBIOTICS AND USES THEREOF

Provided are lincosamide compounds for the treatment of infectious diseases. The lincosamides described herein are modified at the amino acid (southern) region. The lincosamides may have further modification at the C-1 and C-7 positions of the aminooctose (northern) region, thus distinguishing them from lincomycin and clindamycin. Also provided are methods for preparing the lincosamide compounds, pharmaceutical compositions comprising the lincosamide compounds, and methods of treating infectious diseases using the disclosed lincosamide compounds.

Highly enantioselective asymmetric Henry reaction catalyzed by novel chiral phase transfer catalysts derived from cinchona alkaloids

A new type of di-site chiral phase transfer catalyst has been designed and synthesized from cinchona alkaloids as a chiral precursor. The prepared catalysts are applied in the asymmetric Henry reaction to a wide range of aldehydes using mild concentration

Effect of solvent structure on enantioselectivity of lipase-catalyzed transesterification

Enantioselectivity in transesterification of a secondary alcohol under lipase-catalysis is largely affected by the solvent used. Two groups of solvents, cyclic and acyclic, show different feature on enantioselectivity.