6361-33-7

Basic information

• Product Name: N-(1-Naphtyl)benzenemethaneamine
• Synonyms: Benzyl(1-naphtyl)amine;N-(1-Naphtyl)benzenemethaneamine;N-Benzyl-1-naphthalenamine;N-Benzyl-1-naphtylamine;N-Benzylnaphthalene-1-amine;N-(1-phtyl)benzenemethaneamine
• CAS NO: 6361-33-7
• Molecular Formula: C₁₇H₁₅N
• Molecular Weight: 233.3077
• Mol File: 6361-33-7.mol
• Article Data: 100

Chemical Properties

• Melting Point: 66-67 °C
• Boiling Point: 396.8 °C at 760 mmHg
• Flash Point: 208.3 °C
• Appearance: /
• Density: 1.145 g/cm³
• PKA: 4.13±0.50(Predicted)
• CAS DataBase Reference: N-(1-Naphtyl)benzenemethaneamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1-Naphtyl)benzenemethaneamine(6361-33-7)
• EPA Substance Registry System: N-(1-Naphtyl)benzenemethaneamine(6361-33-7)

Safety Data

• Hazardous Substances Data: 6361-33-7(Hazardous Substances Data)

Usage

General Description

N-(1-Naphtyl)benzenemethaneamine, also known as N-(1-naphthyl)benzylamine, is a chemical compound with the molecular formula C18H17N. It is a derivative of benzene and naphthalene, and is commonly used in organic synthesis and as a chemical intermediate in the production of pharmaceuticals and dyes. It is a yellowish solid at room temperature and is soluble in organic solvents such as ethanol and diethyl ether. N-(1-Naphtyl)benzenemethaneamine is also known for its potential application as a reagent in the study and analysis of various organic compounds. Additionally, it has been found to exhibit anti-inflammatory and analgesic properties, making it of interest in the development of new therapeutic agents.

Upstream product

• 67-56-1 methanol 
• 890-51-7 N-benzylidenenaphthalen-1-amine 
• 134-32-7 1-amino-naphthalene 
• 100-52-7 benzaldehyde 
• 100-44-7 benzyl chloride 
• 100-51-6 benzyl alcohol 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 100-46-9 benzylamine 
• 90-14-2 1-Iodonaphthalene 
• 90-11-9 1-Bromonaphthalene 
• 113250-80-9 (2-chlorobenzyl)(naphthalen-1-yl)amine 
• 32848-17-2 1-naphthyl perfluorobutanesulfonate 
• 99747-74-7 1-naphthyl triflate 
• 86-57-7 1-Nitronaphthalene 

Downstream Products

• 115484-79-2 benzyl-[1]naphthyl-carbamic acid-(2-diethylamino-ethyl ester) 
• 890-51-7 N-benzylidenenaphthalen-1-amine 
• 157584-42-4 N-Benzyl-2,2,2-trifluoro-N-naphthalen-1-yl-acetamide 
• 51336-07-3 N,N-dibenzyl-N-(1-naphthyl)amine 
• 909296-95-3 N-allyl-N-benzyl-α-naphthylamine 
• 909296-99-7 (2-allyl-naphthalen-1-yl)-benzyl-amine 
• 909297-03-6 N-(2-allyl-naphthalen-1-yl)-N-benzyl-acetamide 
• 157584-49-1 N-Benzyl-2,2,2-trifluoro-N-naphthalen-1-yl-thioacetamide 
• 944721-88-4 N-(but-2-ynyl)-N-benzylnaphthalen-1-amine 
• 1331748-56-1 N,N'-dibenzyl-(1,1'-binaphthyl)-4,4'-diamine 
• 34987-58-1 2,4-diphenylbenzo[h]quinoline 

Relevant articles and documents

Hydride transfer reactivity of tetrakis(trimethylphosphine)(hydrido) (nitrosyl)molybdenum(0)

The tetrakis(trimethylphosphine) molybdenum nitrosyl hydrido complex trans-Mo(PMe3)4(H)(NO) (2) and the related deuteride complex trans-Mo(PMe3)4(D)(NO) (2a) were prepared from trans-Mo(PMe3)4/s

Iron-catalyzed N-alkylation of aromatic amines via borrowing hydrogen strategy

Earth-abundant transition metals could be used as a noble metal replacement in catalysis not only for different catalytic reactivity but environmentally benign methodology. We report here on the iron-catalyzed synthesis of N-alkylated amines via borrowing hydrogen strategy and differently functionalized aniline derivatives are alkylated in good yields.

[(PPh3)2NiCl2]-Catalyzed C-N bond formation reaction via borrowing hydrogen strategy: Access to diverse secondary amines and quinolines

Commercially available [(PPh3)2NiCl2] was found to be an efficient catalyst for the mono-N-alkylation of (hetero)- A romatic amines, employing alcohols to deliver diverse secondary amines, including the drug intermediates chloropyramine (5b) and mepyramine (5c), in excellent yields (up to 97%) via the borrowing hydrogen strategy. This method shows a superior activity (TON up to 10000) with a broad substrate scope at a low catalyst loading of 1 mol % and a short reaction time. Further, this strategy is also successful in accessing various quinoline derivatives following the acceptorless dehydrogenation pathway.