63637-57-0

Basic information

• Product Name: 1H-Pyrazole, 1-(4-chlorophenyl)-3-phenyl-
• CAS NO: 63637-57-0
• Molecular Formula: C15H11ClN2
• Molecular Weight: 254.719
• Mol File: 63637-57-0.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole, 1-(4-chlorophenyl)-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole, 1-(4-chlorophenyl)-3-phenyl-(63637-57-0)
• EPA Substance Registry System: 1H-Pyrazole, 1-(4-chlorophenyl)-3-phenyl-(63637-57-0)

Safety Data

• Hazardous Substances Data: 63637-57-0(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 19433-17-1 acetophenone O-acetyloxime 
• 106-47-8 4-chloro-aniline 
• 1504-58-1 3-Phenyl-2-propyn-1-ol 
• 1073-69-4 N-4-chlorophenylhydrazine 
• 65-85-0 benzoic acid 
• 75-20-7 calcium carbide 
• 17359-82-9 N-(α-chlorobenzylidene)-N'-p-chlorophenylhydrazine 
• 17473-76-6 N'-(4-chlorophenyl)benzohydrazide 
• 100-52-7 benzaldehyde 
• 98-86-2 acetophenone 
• 3420-52-8 1,4-Diphenylprop-3-en-1-one 
• 107-21-1 ethylene glycol 
• 2833-68-3 benzaldehyde-p-chlorophenylhydrazone 

Relevant articles and documents

The Cycloaddition of N,N-Diethyl-1,3-butadienylamine with Some Diarylnitrilimines

The cycloaddition of N,N-diethyl-1,3-butadienylamine with some diarylnitrilimines was investigated. 1,3-diaryl-4-vinylpyrazoles, (1,3-diaryl-2-pyrazolin-5-yl)acetaldehydes, 1,3-diaryl-4-(1,3-diaryl-2-pyrazolin-5-yl)pyrazoles, and 1,3-diarylpyrazoles were obtained.

[3+2]-cycloaddition of in situ generated nitrile imines and acetylene for assembling of 1,3-disubstituted pyrazoles with quantitative deuterium labeling

A novel synthetic methodology for the preparation of 1,3-disubstituted pyrazoles from in situ generated nitrile imines and acetylene is reported. The reactions are performed in a simple two-chamber reactor. One part of the reactor is loaded with hydrazonoyl chloride precursors of active nitrile imine species and a base. The other part is used to generate acetylene from CaC2 and water. Partitioning of the reactants improves the yields of desired pyrazoles up to 99% and simplifies their isolation to a simple procedure of solvent evaporation. The approach requires no complex equipment and utilizes inexpensive, safe, and easy to handle calcium carbide as a starting material. A model deuterium incorporation is carried out according to the developed methodology, producing a series of novel 4,5-dideuteropyrazoles with excellent deuterium enrichment. Theoretical calculations on reaction mechanism and characterization of possible intermediate structures were performed.

Solvent-dependent copper-catalyzed synthesis of pyrazoles under aerobic conditions

We present a copper-catalyzed oxidative cyclization of β,γ-unsaturated hydrazones, utilizing molecular oxygen as a stoichiometric oxidant. The methodology provides distinct classes of pyrazoles simply by changing the reaction solvent. Tris-substituted pyr