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637027-41-9

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  • 3-Quinolinecarboxylic acid, 5-chloro-1,2-dihydro-4-hydroxy-1-Methyl-2-oxo-, Methyl ester,637027-41-9

    Cas No: 637027-41-9

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637027-41-9 Usage

General Description

"3-Quinolinecarboxylic acid, 5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-, methyl ester" is a chemical compound characterized by its complex structure. Often used in various fields of science and technology, particularly in chemistry and pharmaceuticals, it is known for its purity, effectiveness and stable properties. It is classified in the family of quinolinecarboxylic acids, chemicals that typically have a carboxyl group attached to a quinoline. 3-Quinolinecarboxylic acid, 5-chloro-1,2-dihydro-4-hydroxy-1-Methyl-2-oxo-, Methyl ester as the name suggests also contains a methyl ester functional group, along with chloro and hydroxyl groups. Its exact properties and uses are usually dependent on the particular context or project it is used for.

Check Digit Verification of cas no

The CAS Registry Mumber 637027-41-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,3,7,0,2 and 7 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 637027-41:
(8*6)+(7*3)+(6*7)+(5*0)+(4*2)+(3*7)+(2*4)+(1*1)=149
149 % 10 = 9
So 637027-41-9 is a valid CAS Registry Number.

637027-41-9Relevant articles and documents

An Efficient Method for the Synthesis of Laquinimod

Huang, Yanyan,Feng, Ying,Gao, Wensheng,Zhang, Chao,Chen, Ligong

, p. 437 - 440 (2016/04/19)

Laquinimod, 5-chloro-1,2-dihydro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N- phenyl-3-quinoline carboxamide, is an oral drug in clinical trials for the treatment of multiple sclerosis. An efficient synthetic method for laquinimod from 2-amino-6-chlorobenzoic acid via four steps was established. The overall yield of laquinimod is up to 82% as compared with 70% reported in literature. It has also been demonstrated that green reagent dimethyl carbonate is not suitable for the N-methylation of 5-chloroisatoic anhydride owing to the ring-cleavage reaction induced by the generated methanol. The ring-cleavage by-products were isolated and characterized by 1H-NMR and 13C-NMR. In addition, in the study of laquinimod derivatives, we found that 5-chloro-1,2-dihydro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-3-quinoline carboxamide (laquinimod) was obtained in much higher yield than 7-chloro-1,2-dihydro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-3-quinoline carboxamide under the same reaction conditions, and it is possibly attributed to a neighboring group effect.

METHOD FOR MANUFACTURING OF QUINOLINE-3-CARBOXAMIDES

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Page/Page column 13, (2012/02/01)

A method for preparing a compound of formula (I) by reacting the appropriate alkyl ester and an aniline derivative, in a refluxing mixture containing an aliphatic solvent or a mixture of aliphatic solvents having a boiling point in the range of 68-191 °C; condensing vapors of the refluxing mixture; treating the condensed vapors with an alcohol scavenging agent or a mixture of alcohol scavenging agents; and returning the condensed vapors back to the reaction mixture.

Development of a practical and reliable synthesis of laquinimod

Wennerberg, Johan,Bjoerk, Anders,Fristedt, Tomas,Granquis, Bo,Jansson, Karl,Thuvesson, Ingela

, p. 674 - 680 (2012/12/29)

Laquinimod(5-chloro-1,2-dihydro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl- 3-quinoline carboxamide) is a drug candidate for treatment of Multiple Sclerosis. A short and industrially feasible process for the preparation of laquinimod starting from 2-amino-6-chlorobenzoic acid, in essentially four steps, is discussed. The key step is a novel reaction in which a methyl ester is converted to an amide in very high yield and with excellent purity. The present article elucidates the scale-up process along with safety aspects and the impurity profiles of the intermediates and product. Initial laboratory conditions are described as well as the changes made on transfer to pilot-plant scale.

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