63756-72-9Relevant articles and documents
Hydrogen Tunneling above Room Temperature Evidenced by Infrared Ion Spectroscopy
Sch?fer, Mathias,Peckelsen, Katrin,Paul, Mathias,Martens, Jonathan,Oomens, Jos,Berden, Giel,Berkessel, Albrecht,Meijer, Anthony J. H. M.
, p. 5779 - 5786 (2017)
While hydrogen tunneling at elevated temperatures has, for instance, often been postulated in biochemical processes, spectroscopic proof is thus far limited to cryogenic conditions, under which thermal reactivity is negligible. We report spectroscopic evi
Metal-, Photocatalyst-, and Light-Free Direct C-H Acylation and Carbamoylation of Heterocycles
Westwood, Matthew T.,Lamb, Claire J. C.,Sutherland, Daniel R.,Lee, Ai-Lan
supporting information, p. 7119 - 7123 (2019/09/03)
Direct C-H acylations and carbamoylations of heterocycles can now be readily achieved without requiring any conventional metal, photocatalyst, electrocatalysis, or light activation, thus significantly improving on sustainability, costs, toxicity, waste, and simplicity of the operational procedure. These mild conditions are also suitable for gram-scale reactions and late-stage functionalizations of complex molecules, including pharmaceuticals, N,N-ligands, and light-sensitive molecules.
Visible-Light-Triggered, Metal- and Photocatalyst-Free Acylation of N-Heterocycles
Guillemard, Lucas,Colobert, Fran?oise,Wencel-Delord, Joanna
supporting information, p. 4184 - 4190 (2018/09/25)
A photoinduced acylation of N-heterocycles is explored. This visible-light triggered reaction occurs not only under extremely mild reaction conditions, but also does not require the presence of a photosensitizer. The mechanistic studies suggest formation of EDA complexes prompt to harness the energy from visible-light. Compatibility with a large panel of α-keto acids as acyl precursors and an array of N-heterocycles clearly showcase the synthetic potential of this handy and green acylation protocol. (Figure presented.).
