63762-71-0

Basic information

• Product Name: Ethenamine, 2-(4-chloro-5-methoxy-2-nitrophenyl)-N,N-dimethyl-
• CAS NO: 63762-71-0
• Molecular Formula: C11H13ClN2O3
• Molecular Weight: 256.689
• Mol File: 63762-71-0.mol

Chemical Properties

• Boiling Point: 401.3±45.0 °C(Predicted)
• Density: 1.270±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Ethenamine, 2-(4-chloro-5-methoxy-2-nitrophenyl)-N,N-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethenamine, 2-(4-chloro-5-methoxy-2-nitrophenyl)-N,N-dimethyl-(63762-71-0)
• EPA Substance Registry System: Ethenamine, 2-(4-chloro-5-methoxy-2-nitrophenyl)-N,N-dimethyl-(63762-71-0)

Safety Data

• Hazardous Substances Data: 63762-71-0(Hazardous Substances Data)

Upstream product

• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 118664-99-6 1-chloro-2-fluoro-4-methyl-5-nitrobenzene 
• 40130-97-0 2-chloro-5-methyl-4-nitro-phenol 
• 615-74-7 2-chloro-5-methylphenol 
• 62492-45-9 2-nitro-4-chloro-5-methoxymethylbenzene 
• 52755-02-9 N,N-dimethylformamide dimethyl acetal 

Downstream Products

• 63762-74-3 N-[2-(6-chloro-5-methoxy-indol-3-yl)-ethyl]-acetamide 
• 63762-72-1 6-chloro-5-methoxy-1H-indole 

Relevant articles and documents

From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3βinhibitors that suppress proliferation and survival of pancreatic cancer cells

Recent studies have demonstrated that glycogen synthase kinase 3β (GSK-3β) is overexpressed in human colon and pancreatic carcinomas, contributing to cancer cell proliferation and survival. Here, we report the design, synthesis, and biological evaluation of benzofuran-3-yl-(indol-3-yl) maleimides, potent GSK-3β inhibitors. Some of these compounds show picomolar inhibitory activity toward GSK-3β and an enhanced selectivity against cyclin-dependent kinase 2 (CDK-2). Selected GSK-3β inhibitors were tested in the pancreatic cancer cell lines MiaPaCa-2, BXPC-3, and HupT3. We determined that some of these compounds, namely compounds 5, 6, 11, 20, and 26, demonstrate antiproliferative activity against some or all of the pancreatic cancer cells at low micromolar to nanomolar concentrations. We found that the treatment of pancreatic cancer cells with GSK-3β inhibitors 5 and 26 resulted in suppression of GSK-3β activity and a distinct decrease of the X-linked inhibitor of apoptosis (XIAP) expression, leading to significant apoptosis. The present data suggest a possible role for GSK-3β inhibitors in cancer therapy, in addition to their more prominent applications in CNS disorders.

Synthesis and evaluation of the antiovulatory activity of a variety of melatonin analogues

A series of melatonin analogues was synthesized and examined for ovulation-blocking activity. Deviation from the 5-methoxy group or substitution of the 1 position prevented activity. Activity was not particularly sensitive to minor variations in the N-acyl group nor was it significantly altered by methylation of position 2 or the α-methylene; however, a pronounced enhancement resulted from halogenation of the 6 position.