63762-72-1

Basic information

• Product Name: 1H-Indole, 6-chloro-5-Methoxy-
• Synonyms: 1H-Indole, 6-chloro-5-Methoxy-;6-Chloro-5-methoxyindole
• CAS NO: 63762-72-1
• Molecular Formula: C9H8ClNO
• Molecular Weight: 181.61892
• Mol File: 63762-72-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 140-142℃
• Boiling Point: 331℃
• Flash Point: 154℃
• Appearance: /
• Density: 1.317
• Vapor Pressure: 0.000315mmHg at 25°C
• Refractive Index: 1.647
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 15.80±0.30(Predicted)
• CAS DataBase Reference: 1H-Indole, 6-chloro-5-Methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 6-chloro-5-Methoxy-(63762-72-1)
• EPA Substance Registry System: 1H-Indole, 6-chloro-5-Methoxy-(63762-72-1)

Safety Data

• Hazardous Substances Data: 63762-72-1(Hazardous Substances Data)

Usage

General Description

"1H-Indole, 6-chloro-5-methoxy-" is a specialized type of chemical compound belonging to the class of organic substances known as Indoles. The core structure of these chemicals is a bicyclic system, incorporating a six-membered benzene ring and a five-membered nitrogen-containing pyrrole ring. Specifically for this chemical, it has substituents - positions 6 and 5 of the indole ring system are substituted by chlorine and a methoxy group respectively. This makes it a unique derivative within the family of Indole compounds. Its applications, toxicity and properties can vary widely and are largely influenced by this unique structural conformation. Generally, it's used as a building block in pharmaceuticals and materials science, but the exact use would depend on further modifications to its structure.

InChI:InChI=1/C9H8ClNO/c1-12-9-4-6-2-3-11-8(6)5-7(9)10/h2-5,11H,1H3

Upstream product

• 1203844-49-8 C₁₃H₁₅ClN₂O₃ 
• 62492-45-9 2-nitro-4-chloro-5-methoxymethylbenzene 
• 40130-97-0 2-chloro-5-methyl-4-nitro-phenol 
• 615-74-7 2-chloro-5-methylphenol 
• 99474-19-8 2-(4-chloro-5-methoxy-2-nitrophenyl)-1-dimethylamino ethylene 
• 63762-71-0 2-chloro-5-<(β-dimethylamino)-vinyl>-4-nitroanisole 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 118664-99-6 1-chloro-2-fluoro-4-methyl-5-nitrobenzene 

Downstream Products

• 63762-74-3 N-[2-(6-chloro-5-methoxy-indol-3-yl)-ethyl]-acetamide 
• 63762-73-2 (6-chloro-5-methoxy-indol-3-yl)-acetonitrile 
• 164084-11-1 2-(1-Benzyl-2-bromo-6-chloro-5-methoxy-1H-indol-3-yl)-acetamide 
• 164083-10-7 (1-Benzyl-2-bromo-6-chloro-5-methoxy-1H-indol-3-yl)-acetic acid methyl ester 
• 164083-09-4 (1-Benzyl-6-chloro-5-methoxy-1H-indol-3-yl)-acetic acid methyl ester 

Relevant articles and documents

KINASE INHIBITORS AND METHODS OF USE

The present invention provides chemical entities or compounds and pharmaceutical compositions thereof that are capable of modulating certain protein kinases such as mTor, tyrosine kinases, and/or lipid kinases such as PI3 kinase. Also provided in the present invention are methods of using these compositions to modulate activities of one or more of these kinases, especially for therapeutic applications.

Melatonin derivatives - I - Synthesis of N-succinyl-6-chloro-5-methoxytryptamine

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Synthesis and evaluation of the antiovulatory activity of a variety of melatonin analogues

A series of melatonin analogues was synthesized and examined for ovulation-blocking activity. Deviation from the 5-methoxy group or substitution of the 1 position prevented activity. Activity was not particularly sensitive to minor variations in the N-acyl group nor was it significantly altered by methylation of position 2 or the α-methylene; however, a pronounced enhancement resulted from halogenation of the 6 position.