63762-74-3 Hazards Identification
Signal:
Danger
GHS Hazard Statements:
H301 (97.44%): Toxic if swallowed [Danger Acute toxicity, oral]
H311 (97.44%): Toxic in contact with skin [Danger Acute toxicity, dermal]
H315 (97.44%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (97.44%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H331 (97.44%): Toxic if inhaled [Danger Acute toxicity, inhalation]
H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
H360 (97.44%): May damage fertility or the unborn child [Danger Reproductive toxicity]
Precautionary Statement Codes:
P203, P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P318, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501
Hazard Classes and Categories:
Acute Tox. 3 (97.44%)
Skin Irrit. 2 (97.44%)
Eye Irrit. 2 (97.44%)
STOT SE 3 (100%)
Repr. 1B (97.44%)
63762-74-3 Usage
Uses
6-Chloromelatonin is a potent agonist of the melatonin receptors.
Biological Activity
Potent melatonin agonist (pK i values are 9.10 and 9.77 for human recombinant MT 1 and MT 2 receptors respectively). Displays higher affinity for binding to hamster brain membrane and chicken retina than melatonin.
Check Digit Verification of cas no
The CAS Registry Mumber 63762-74-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,7,6 and 2 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 63762-74:
(7*6)+(6*3)+(5*7)+(4*6)+(3*2)+(2*7)+(1*4)=143
143 % 10 = 3
So 63762-74-3 is a valid CAS Registry Number.
InChI:InChI=1/C13H15ClN2O2/c1-8(17)15-4-3-9-7-16-12-6-11(14)13(18-2)5-10(9)12/h5-7,16H,3-4H2,1-2H3,(H,15,17)
63762-74-3Relevant academic research and scientific papers
Synthesis and evaluation of the antiovulatory activity of a variety of melatonin analogues
Flaugh,Crowell,Clemens,Sawyer
, p. 63 - 69 (2007/10/04)
A series of melatonin analogues was synthesized and examined for ovulation-blocking activity. Deviation from the 5-methoxy group or substitution of the 1 position prevented activity. Activity was not particularly sensitive to minor variations in the N-acyl group nor was it significantly altered by methylation of position 2 or the α-methylene; however, a pronounced enhancement resulted from halogenation of the 6 position.
Amides as ovulation inhibitors
-
, (2008/06/13)
N-[2-(5-methoxy-6-haloindol-3-yl)ethyl]amides are valuable, orally active, ovulation inhibitors.
