63853-74-7

Basic information

• Product Name: 5-METHOXY-2-PYRROLIDINONE
• Synonyms: 5-METHOXY-2-PYRROLIDINONE;5-Methoxy-2-oxopyrrolidine
• CAS NO: 63853-74-7
• Molecular Formula: C₅H₉NO₂
• Molecular Weight: 115.13
• Product Categories: Various Intermediates;Intermediates;Heterocycles
• Mol File: 63853-74-7.mol
• Article Data: 21

Chemical Properties

• Melting Point: 52-55°C
• Boiling Point: 87-90°C@0.14Hg
• Flash Point: 116.2°C
• Appearance: /
• Density: 1.1g/cm³
• Vapor Pressure: 0.00767mmHg at 25°C
• Refractive Index: 1.46
• Storage Temp.: Hygroscopic, Refrigerator, Under Inert Atmosphere
• Solubility: DMSO (Soluble), Methanol (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: 5-METHOXY-2-PYRROLIDINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHOXY-2-PYRROLIDINONE(63853-74-7)
• EPA Substance Registry System: 5-METHOXY-2-PYRROLIDINONE(63853-74-7)

Safety Data

• Hazardous Substances Data: 63853-74-7(Hazardous Substances Data)

Usage

Chemical Properties

5-METHOXY-2-PYRROLIDINONE is White Solid

Uses

Different sources of media describe the Uses of 63853-74-7 differently. You can refer to the following data:
1. 5-METHOXY-2-PYRROLIDINONE is a useful sythetic intermediate
2. An intermediate in the synthesis
3. An intermediate in the synthesis of γ-lactam analogs of penems and carbapenems.

InChI:InChI=1/C5H9NO2/c1-8-5-3-2-4(7)6-5/h5H,2-3H2,1H3,(H,6,7)

Upstream product

• 67-56-1 methanol 
• 149-87-1 Pyroglutamic acid 
• 124-41-4 sodium methylate 
• 39662-63-0 5-ethoxy-pyrrolidin-2-one 
• 62312-55-4 rac-4-hydroxy-2-pyrrolidone 
• 33744-04-6 1-chloropyrrolidin-2-one 
• 123-56-8 Succinimide 
• 616-45-5 2-pyrrolidinon 

Downstream Products

• 119984-22-4 1-benzoyl 5-methoxy pyrrolidin-2-one 
• 76284-14-5 5-(phenylamino)pyrrolidin-2-one 
• 76284-15-6 5-(benzylamino)pyrrolidin-2-one 
• 91703-06-9 5-(4-phenylpiperazin-1-yl)pyrrolidin-2-one 

Relevant articles and documents

Cesium salts as superior catalysts for solvent-free modifications of biosourced pterolactam

γ-Lactam derivatives are widespread biologically active compounds, covering a large range of activities. Following our interest in both medicinal and green chemistries, we developed an original, cesium salts-mediated, scalable and solvent-free methodology to transform biosourced pyroglutamic acid and its derivatives to their N,N′-aminals, N,O,N,S-acetals and C5-substituted γ-lactams in good to excellent yields. This protocol is applicable to a large range of substrates, conducting to C5-substituted γ-lactam derivatives as potential new biologically active compounds.

3,5-Disubstituted-indole-7-carboxamides as IKKβ Inhibitors: Optimization of Oral Activity via the C3 Substituent

IκB kinase β (IKKβ or IKK2) is a key regulator of nuclear factor kappa B (NF-κB) and has received attention as a therapeutic target. Herein we report on the optimization of a series of 3,5-disubstituted-indole-7-carboxamides for oral activity. In doing so

Impact of Functional Groups on the Copper-Initiated N-Arylation of 5-Functionalized Pyrrolidin-2-ones and Their Vinylogues

The electronic effects governing the N-arylation of pyrrolidone were investigated. The generalization of our preliminary findings on a copper(I)-catalyzed Csp2-N coupling process was first improved with a wide variety of aryl and heteroaryl halides and methyl pyroglutamate. The optimized protocol was further extended to pyrrolidin-2-ones substituted at the C5-position with an aryl group bearing an electron-donating or electron-withdrawing group as well as to some of their substituted enaminoester vinylogues. The impact of substituents at the N- and C5-position on these coupling processes seemed to be pivotal for determining both the reaction profiles and yields.